A5046517741- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Phagocytosis and Immune Regulation
- Blood properties and coagulation
- Advanced Proteomics Techniques and Applications
- Nitric Oxide and Endothelin Effects
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac electrophysiology and arrhythmias
- Ultrasound and Hyperthermia Applications
- Metabolomics and Mass Spectrometry Studies
- Cardiac Imaging and Diagnostics
- Takotsubo Cardiomyopathy and Associated Phenomena
- Extracellular vesicles in disease
- Radiopharmaceutical Chemistry and Applications
- Radioactive Decay and Measurement Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Lipids, and Metabolism
- Apelin-related biomedical research
- Healthcare Systems and Public Health
- Eicosanoids and Hypertension Pharmacology
- Adenosine and Purinergic Signaling
- Cell Adhesion Molecules Research
Centro Cardiologico Monzino
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2021
University of Salford
2016
University of Florence
2016
King's College London
2016
Institute of Experimental Cardiology
2016
Imperial College London
2016
The authors hypothesized that the cytokine storm described in COVID-19 patients may lead to consistent cell-based tissue factor (TF)-mediated activation of coagulation, procoagulant microvesicles (MVs) release, and massive platelet activation. have higher levels TF+ platelets, granulocytes, MVs than healthy subjects coronary artery disease patients. Plasma MV-associated thrombin generation is present prophylactic anticoagulated A sustained terms P-selectin expression platelet–leukocyte...
Reactive oxygen species (ROS) induce nuclear factor erythroid 2–related 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). HO-1 protects cells against oxidative injury, degrading free heme and inhibiting ROS production. is highly expressed in macrophages during plaque growth. Macrophages are morpho-functionally heterogeneous, prevalence a specific phenotype may influence fate. This heterogeneity has...
The association between migraine and patent foramen ovale (PFO) has been documented. We aimed to investigate platelet activation, prothrombotic phenotype, oxidative stress status of migraineurs with PFO on 100 mg/day aspirin, before 6 months after closure. Data show that, closure, expression the classical activation markers is comparable in patients aspirin-treated healthy subjects. Conversely, MHA-PFO display an increased phenotype (higher tissue factorpos platelets microvesicles...
Abstract The prevalence of a macrophage phenotype in atherosclerotic plaque may drive its progression and/or instability. Macrophages from coronary plaques are not available, and monocyte-derived macrophages (MDMs) usually considered as surrogate. We compared the MDM profile obtained artery disease (CAD) patients healthy subjects, we evaluated association between CAD vivo characteristics assessed by optical coherence tomography (OCT). At morphological analysis, MDMs had higher round than...
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth family, well known for its role in homeostasis cardiovascular system. Recently, human BDNF Val66Met single nucleotide polymorphism has been associated with increased propensity arterial thrombosis related to acute myocardial infarction (AMI). Using cardiac magnetic resonance imaging and immunohistochemistry analyses, we showed that homozygous mice carrying (BDNFMet/Met) undergoing left anterior descending (LAD)...
Abstract Circulating levels of Brain Derived Neurotrophic Factor (BDNF) are lower in coronary heart disease (CHD) than healthy subjects and associated with events mortality. However, the mechanism(s) underling this association is not fully understood. We hypothesize that BDNF may influence fibrin fiber structure clot stability, favoring lysis thrombus resolution. showed recombinant (rh-BDNF) influenced formation a concentration-dependent manner both purified fibrinogen plasma from subjects....
A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a pivotal role in different cardiovascular pathologies. As red blood cells (RBCs) participate NO formation the bloodstream, aim of this study was to outline metabolic profile L-arginine (Arg)/NO pathway status RBCs plasma patients with microvascular angina (MVA), investigating similarities differences respect coronary artery disease (CAD) or healthy controls (Ctrl). Analytes involved Arg/NO ratio oxidized...
In the last years, a substantial contribution of red blood cells (RBCs) in cardiovascular homeostasis has been evidenced, as these are able to regulate function by export adenosine triphosphate and nitric oxide well maintain redox balance through well-developed antioxidant system. Recently link between high-risk plaque (HRP) features myocardial ischemia, absence severe lumen stenosis, evidenced. Nonobstructive coronary artery disease (nonob CAD) associated fact with greater 1-year risk...
Netrin-1 is a laminin-like protein that plays pivotal role in cell migration and, according to the site of its release, exerts both pro and anti-atherosclerotic functions. Macrophages, key cells atherosclerosis, are heterogeneous morphology function different subpopulations may support plaque progression, stabilization, and/or regression. was evaluated plasma together with receptor UNC5b, spindle round monocyte-derived macrophages (MDMs) morphotypes from coronary artery disease (CAD)...
Introduction: Familial hypercholesterolemia (FH) is characterized by extremely high levels of circulating low-density lipoprotein cholesterol (LDL-C) and caused mutations genes involved in LDL-C metabolism, including LDL receptor (LDLR), apolipoprotein B (APOB), or proprotein convertase subtilisin/Kexin type 9 (PCSK9). Accordingly, PCSK9 inhibitors (PCSK9i) are effective reduction. However, no data available on the pleiotropic effect PCSK9i. To this end, we performed an untargeted...
Given to its ability irreversibly acetylate the platelet cyclooxygenase-1 enzyme, acetylsalicylic acid (ASA) is successfully employed for prevention of cardiovascular disease. Recently, an antitumoral effect ASA in colorectal cancer has been increasingly documented. However, molecular and metabolic mechanisms by which exerts such largely unknown. Using a new, untargeted liquid chromatography-mass spectrometry approach, we have analyzed urine samples from seven healthy participants that each...
Takotsubo (TTS) syndrome is an acute cardiac condition characterized by transient and reversible left ventricle dysfunction that mainly affects postmenopausal women. Catecholamine burst the most accredited mechanism underpinning TTS onset leading to endothelial platelet activation. Even if use of low dose acetylsalycilic acid (ASA) in this clinical setting based on both presentation unfavorable long-term prognosis, its efficacy has been recently challenged. This study was designed assess...
Monocyte recruitment after vascular injury and their migration through the vessel wall represent crucial events in initiation, progression, destabilization of atherosclerotic plaque. Circulating monocytes are exposed to stimuli that alter physiological state, among them, lipids play a key role. Several studies investigated mechanisms by which affect monocyte functions promoting coronary plaque but information on relationship between lipid composition function is scant. We aimed at studying...
This data article is referred to the research entitled Human monocyte-derived macrophages are heterogeneous: proteomic profile of different phenotypes by Eligini et al. S., Brioschi M., Fiorelli Tremoli E., Banfi C., Colli S. phenotypes. J. Proteomics 124, 2015, 112-123. Macrophages obtained in vitro from blood monocytes largely used as surrogate model tissue that heterogeneous and not easy obtain handle. Under spontaneous differentiation vitro, (MDMs) display two dominant subsets (round...
Cardiovascular risk factors in general population / Vascular biology and the microcirculation 727 by their HDL-C levels.Cox proportional hazard models stratified cohorts were used to estimate ratios (HRs) after adjusting for age, sex, non-HDL-C, hypertension, diabetes, smoking alcohol drinking.Results: During follow-up, we observed 289 deaths due CHD 265 ischemic stroke.The relationship between was U-shaped.The lowest HRs 3rd 4th groups (HDL-C: 40-59, 60-79 mg/dl), of which 1.0 (reference)...
Coronary artery disease: from bench to bedside 399 control of blood pressure by an amlodipine on the progression/regression coronary plaque, demonstrated that treatment with both agents enhanced regression plaque.Under these conditions, baseline high-sensitive C-reactive protein (hs-CRP) is thought play important role in atherogenesis.Purpose: We tested hypothesis hs-CRP affects combined statin and therapy predicts changes plaque volume.Methods results: Sixty eight patients (55 men, mean age...
Novel aspects in atherosclerosis 1399in the exacerbation of inflammation and endothelial dysfunction patients with coronary artery disease.However, role non-apoptotic MPs has not been elucidated yet.Purpose: To assess correlation circulating apoptotic inflammatory status function a recent acute syndrome.Methods: 49 ST-elevation myocardial infarction/STEMI, 35 non-STEMI/NSTEMI, 38 unstable angina/UA, 15 stable disease (SCAD) 16 healthy volunteers were included.Flow cytometry analysis was...