A5045375055- Cardiovascular Function and Risk Factors
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
- Renin-Angiotensin System Studies
- Cardiac Imaging and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Advanced MRI Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Hormonal Regulation and Hypertension
- Inflammatory mediators and NSAID effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Immune cells in cancer
- Nitric Oxide and Endothelin Effects
- S100 Proteins and Annexins
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Parkinson's Disease and Spinal Disorders
- Computational Drug Discovery Methods
- Extracellular vesicles in disease
- Acute Ischemic Stroke Management
- Signaling Pathways in Disease
- Estrogen and related hormone effects
University of Milan
2014-2024
Ospedale Sandro Pertini
2024
Ospedali Riuniti di Ancona
2023
Hospital Universitario de Móstoles
2021
Istituto Ramazzini
2016
University of Bologna
2005-2013
Radboud University Nijmegen
2012
Radboud University Medical Center
2012
University of L'Aquila
2008
Policlinico S.Orsola-Malpighi
2005
Sex has a role in the incidence and outcome of neurological illnesses, also influencing response to treatments. Neuroinflammation is involved onset progression several diseases, fact that estrogens have anti-inflammatory activity suggests these hormones may be determinant sex-dependent manifestation brain pathologies. We describe significant differences transcriptome adult male female microglia, possibly originating from perinatal exposure sex steroids. Microglia isolated brains maintain...
Abstract Aims PCSK9 is secreted into the circulation, mainly by liver, and interacts with low-density lipoprotein receptor (LDLR) homologous non-homologous receptors, including CD36, thus favouring their intracellular degradation. As deficiency increases expression of lipids contributing to cellular lipid accumulation, we investigated whether this could affect heart metabolism function. Methods results Wild-type (WT), Pcsk9 KO, Liver conditional KO Pcsk9/Ldlr double male mice were fed for 20...
Contrasting myelin damage through the generation of new myelinating oligodendrocytes represents a promising approach to promote functional recovery after stroke. Here, we asked whether activation microglia and monocyte-derived macrophages affects regenerative process sustained by G protein-coupled receptor 17 (GPR17)-expressing oligodendrocyte precursor cells (OPCs), subpopulation OPCs specifically reacting ischemic injury. GPR17-iCreERT2:CAG-eGFP reporter mice were employed trace fate...
Angiotensin II acts through two major receptors: AT1-R and AT2-R. It is known that the stimulation of mediates vasoconstriction, cell proliferation fibrosis, aldosterone release inflammatory response but, although AT2-R thought to promote vasodilation anti-inflammatory effects, its real in-vivo functions are still unclear. The aim this study was investigate effects specific selective on pathological events occurring in spontaneously hypertensive stroke-prone rats (SHRSPs).SHRSPs who were fed...
The treatment of glioblastoma (GBM) faces significant challenges due to the difficulty delivering drugs through blood-brain barrier (BBB). Extracellular vesicles (EVs) have emerged as potential carriers for targeted drug delivery brain tumors. However, their use and distribution in presence an intact BBB ability target GBM tissue are still under investigation. This study explored EVs targeting across BBB. Canine plasma from healthy dogs with glioma were isolated, characterized, loaded...
Background The pericardial tissue is commonly used to produce bio-prosthetic cardiac valves and patches in surgery. procedures adopted prepare this consist treatment with aldehydes, which do not prevent post-graft calcification due incomplete xeno-antigens removal. adoption of fixative-free decellularization protocols has been therefore suggested overcome limitation. Although promising, the decellularized pericardium yet clinics, absence proofs indicating that cryopreservation can...
Tuberculosis (TB) is one of the leading causes death worldwide. Over last decades, TB has also emerged in pediatric population. Epidemiologic data childhood are still limited and there an urgent need more on very large cohorts. A multicenter study was conducted 27 hospitals, wards, public health centers Italy using a standardized form, covering period time between 1 January 2010 31 December 2012. Children with active TB, latent those recently exposed to or adopted/immigrated from high...
Background: Basic science studies have reported remote ischemic conditioning (RIC) as neuroprotective in acute stroke, while clinical evidence remains conflicting. The TRICS BASIC study investigated the efficacy and safety of RIC experimental stroke using a rigorous trial methodology. Methods: Multi-center, multi-species, parallel group, randomized, controlled, preclinical transient femoral artery clipping to induce female male rats mice subjected endovascular occlusion middle cerebral...
A growing body of evidence suggests that chronic kidney disease is a significant risk for cardiovascular events and stroke regardless traditional factors. The aim this study was to examine the effects peroxisome proliferator-activated receptor (PPAR) agonists on tissue damage affecting salt-loaded spontaneously hypertensive stroke-prone rats ( SHRSPs), an animal model develops complex pathology characterized by systemic inflammation, hypertension, proteinuria leads end-organ injury...
Doxorubicin (DOX) is a chemotherapeutic drug limited in its usefulness by an adverse side effect, cardiotoxicity. The mechanisms leading to this detrimental occurrence are not completely clear, and lately many authors focused their attention on the possible role of microRNAs (miRNAs), small regulators cardiovascular functions, phenomenon. Notably, these molecules recently emerged also as potential circulating biomarkers several cardiac diseases. Thus, aim study was simultaneous investigation...
This study investigated the efficacy of terutroban, a specific thromboxane/prostaglandin endoperoxide receptor antagonist, on stroke incidence in spontaneously hypertensive stroke-prone rats (SHRSP). The effects terutroban were compared with those aspirin, another antiplatelet agent, and rosuvastatin, known to exert end-organ protection SHRSP. Salt-loaded male SHRSP treated orally once day vehicle, (30 mg/kg/day), aspirin (60 or rosuvastatin (10 mg/kg/day). Compared regardless any effect...
Background Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, particular asthma. Here, we investigated whether cys-LT signaling, the context of atherosclerotic heart disease, compromises myocardial microcirculation its response to hypoxic stress. To this end, examined Apoe−/− mice fed a hypercholesterolemic diet analysed expression key enzymes pathway their receptors (CysLT1/CysLT2) normal myocardium as well...
Background . Cardiotoxicity is a detrimental side effect of the anticancer drug doxorubicin (DOX), characterized by progressive heart dysfunction. Circulating microRNAs (miRNAs) are recognized as potential biomarkers cardiac disease; thus, we aimed to investigate their association with late cardiotoxicity in an animal model disease. Methods. Twenty C57BL/6 female mice were administered 24 mg/kg cumulative dose DOX or saline during 2 weeks, followed recovery period one month (T42)....
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth family, well known for its role in homeostasis cardiovascular system. Recently, human BDNF Val66Met single nucleotide polymorphism has been associated with increased propensity arterial thrombosis related to acute myocardial infarction (AMI). Using cardiac magnetic resonance imaging and immunohistochemistry analyses, we showed that homozygous mice carrying (BDNFMet/Met) undergoing left anterior descending (LAD)...
Abstract Preclinical and clinical data indicate that the 5-lipoxygenase pathway becomes activated in cardiovascular diseases suggesting an important role of CysLTs atherosclerosis its ischemic complications. This study aims to investigate effects montelukast, a CysLTR-1 antagonist, mouse model myocardial infarction (MI). C57BL/6N female mice were subjected coronary artery ligation received montelukast (10 mg/kg/day, intraperitoneal) or vehicle. Montelukast exerted beneficial infarcted area,...
Mild insulin resistance appears to be an early metabolic defect in girls with Turner syndrome (TS). Impaired glucose tolerance has been reported 10–34% of patients TS, and type 2 diabetes mellitus is 2–4 times more common occurs at a younger age TS than the general population. In mixed longitudinal cross-sectional study, we analysed carbohydrate sensitivity 46 children adolescents who reached their final height after long-term treatment (mean 6.3 ± 2.5 years) growth hormone (GH: 0.33...
Thromboxane A(2) and other eicosanoids such as isoprostanes contribute to vascular proliferation atherosclerosis by binding the thromboxane/prostaglandin endoperoxide receptors. The effects of terutroban, a receptor antagonist, on aorta remodeling were evaluated in spontaneously hypertensive stroke-prone rats (SHRSPs), model severe hypertension, endothelial dysfunction, inflammation, cerebrovascular diseases. Male SHRSPs allocated three groups receiving standard diet (n = 5) or high-sodium...
Abstract GPR 17 is a G i ‐coupled dual receptor activated by uracil‐nucleotides and cysteinyl‐leukotrienes. These mediators are massively released into hypoxic tissues. In the normal heart, expression has been reported. By contrast, its role in myocardial ischaemia not yet assessed. present report, of was investigated mice before at early stages after infarction using immunofluorescence, flow cytometry RT ‐ PCR . Before induction ischaemia, results indicated presence population stromal cells...