INTRODUCTION: Early brain injury (EBI) and cerebral vasospasm are major complications of aneurysmal subarachnoid hemorrhage (aSAH) that significantly increase mortality morbidity. Prevention these is crucial; however, despite extensive research, current treatments remain inadequate. METHODS: 40 Wistar Albino rats were randomly divided into four groups: Sham (n = 10), SAH Osthole + 10). was induced in groups 2 4 by injecting autologous blood the cisterna magna. Groups 3 received osthole (30...

Introduction: Bladder cancer is responsible for more than 130,000 deaths annually worldwide. Intravesical delivery of chemotherapeutic agents provides effective drug localization to the target area reduce toxicity and increase efficacy. This study aimed develop an intravesical system gemcitabine HCl (Gem-HCl) provide a sustained-release profile, prolong residence time, enhance its efficiency in treatment bladder cancer. Materials methods: For this purpose, bioadhesive microspheres were...

Thromboxane A(2) and other eicosanoids such as isoprostanes contribute to vascular proliferation atherosclerosis by binding the thromboxane/prostaglandin endoperoxide receptors. The effects of terutroban, a receptor antagonist, on aorta remodeling were evaluated in spontaneously hypertensive stroke-prone rats (SHRSPs), model severe hypertension, endothelial dysfunction, inflammation, cerebrovascular diseases. Male SHRSPs allocated three groups receiving standard diet (n = 5) or high-sodium...

Hypercholesterolemia is a major risk factor for atherosclerosis and related occlusive vascular diseases. We investigated the effect of low‐dose fluvastatin (2 mg kg −1 day ) on antioxidant enzyme activities [superoxide dismutase (SOD), catalase], reactivity changes oxidatively induced DNA damage in early stage hypercholesterolemic rabbits. The animals were divided into three groups each composed 10 control group received regular rabbit chow diet, cholesterol had diet (2%, 4 weeks). was given...

Prostate cancer is the second leading cause of morbidity and mortality in males Western world. In present study, LNCaP, which an androgen receptor-positive androgen-responsive prostate cell line derived from lymph node metastasis, DU145, receptor-negative brain were investigated. TNFα treatment decreased p105 p50 expression R1881 slightly but increased with or without induction. As aggressive line, DU145 transfected six transmembrane protein (STAMP)1 STAMP2 was also exposed to TNFα. blotting...

Cataract which is defined as opacification of eye lens forms approximately 40% total blindness causes all through the world. Age biggest risk factor for cataracts and oxidative stress known to be one most important factors causing cataract formation. Age-related nuclear (ARN) associated with a loss glutathione in center lens. Taurine an antioxidant tissue. Although, there high amount taurine lenses early life, its concentration declines age. In this study, we aimed investigate effects...

Abstract: Vitamin C has efficient antioxidant properties and is involved in important physiological processes such as collagen synthesis. As such, vitamin deficiency leads to serious complications, including vascular diseases. The aim of this study was investigate the effects treatment on collar-induced intimal thickening. Rabbits were fed a normocholesterolemic diet non-occlusive silicon collar placed around left carotid artery for 3, 7, 14 days. rabbits treated with or without (150...

Abstract A series of piperidine‐3‐carbohydrazide‐hydrazones bearing phenylethyl, phenylpropyl, and phenylbutyl substituents on piperidine nitrogen were designed synthesized as cholinesterase (ChE) inhibitors. The title compounds screened for acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) inhibitory activities antioxidant capacities, the active ones Aβ 42 self‐aggregation inhibition, in vitro. chemiluminescence method was used to determine effect selected reactive oxygen species...

To investigate whether carboxymethylcellulose/polyethylene oxide (CMC/PEO) gel has a protective effect against epidural scar formation anterior to the dura following discectomy.A barrier comprised of CMC and PEO (MediShield) was studied as material reduce in rabbit laminotomy discectomy model. After disc puncture, surgical side either treated with MediShield or used control, determined by random allocation. Two months after surgery, animals were euthanized, their lumbar spines removed an en...

The effects of nicardipine treatment on collar-induced intimal thickening and accompanying reactivity changes in rabbit carotid artery have been investigated. Treatment for three weeks with subcutaneous (20 mgkg(-1) per day) significantly inhibited the caused by perivascular application a silicone rubber collar. Potassium chloride (KCl), phenylephrine 5-hydroxytryptamine (5-HT) induced concentration-dependent contractions both sham-operated collared arteries. Collar-induced attenuation...

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly known as statins, are the medical treatment of choice for hypercholesterolemia. In addition to lowering serum-cholesterol levels, statins appear promote pleiotropic effects that independent changes in serum cholesterol. this study, we investigated low-dose fluvastatin on antioxidant enzyme activities (superoxide dismutase, SOD; catalase), total nitrite/nitrate and vascular reactivity 2% cholesterol-fed rabbits....

Calcium channel blockers (CCBs) are among the most frequently prescribed cardiovascular drugs. It has been shown that these drugs have antiatherosclerotic effects in both experimental and clinical settings. However, calcium markedly different chemical structures on system. We investigated effect of CD-832, a Ca(+2) antagonist, collar-induced intimal thickening, as well accompanied reactivity changes rabbit carotid artery.Rabbits received 5 mg/kg/day CD-832 or vehicle (polyethylene glycol,...