A5050420481- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Ischemia and Reperfusion
- Streptococcal Infections and Treatments
- Anesthesia and Neurotoxicity Research
- Boron Compounds in Chemistry
- Infective Endocarditis Diagnosis and Management
- Bacterial Infections and Vaccines
- Neuroscience and Neuropharmacology Research
- Chemokine receptors and signaling
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
Vita-Salute San Raffaele University
2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2025
Mario Negri Institute for Pharmacological Research
2021
CXCL1, a functional murine orthologue of the human chemokine CXCL8 (IL-8), and its CXCR1 CXCR2 receptors were investigated in model acquired epilepsy developing following status epilepticus (SE) induced by intra-amygdala kainate. also studied temporal lobe (TLE). The involvement seizure generation neuronal cell loss was assessed mice using reparixin (formerly referred to as repertaxin), non-competitive allosteric inhibitor CXCR1/2 receptors. We found significant increase hippocampal CXCL1...
Introduction: Infective endocarditis (IE) is a life-threatening condition and rare cause of ischemic stroke (IS). This study aimed to evaluate the utility analyzing cerebral thrombi, obtained through endovascular thrombectomy in IS, for pathological diagnosis IE. Patients methods: Cerebral thrombi from three groups IS patients were compared: definite IE ( n = 10), cardioembolic without with concomitant infection (CE-I − : 30, CE-I + 10). We performed histological examination, molecular...
Background: Basic science studies have reported remote ischemic conditioning (RIC) as neuroprotective in acute stroke, while clinical evidence remains conflicting. The TRICS BASIC study investigated the efficacy and safety of RIC experimental stroke using a rigorous trial methodology. Methods: Multi-center, multi-species, parallel group, randomized, controlled, preclinical transient femoral artery clipping to induce female male rats mice subjected endovascular occlusion middle cerebral...