A5072192699- Lipoproteins and Cardiovascular Health
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Healthcare Systems and Public Health
- Pancreatic function and diabetes
- Orthopaedic implants and arthroplasty
- Protease and Inhibitor Mechanisms
- Epigenetics and DNA Methylation
- Axon Guidance and Neuronal Signaling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Folate and B Vitamins Research
- Caveolin-1 and cellular processes
- Platelet Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Electron and X-Ray Spectroscopy Techniques
- Lung Cancer Treatments and Mutations
- Peripheral Artery Disease Management
- HER2/EGFR in Cancer Research
- Tissue Engineering and Regenerative Medicine
- Signaling Pathways in Disease
- Diabetes Treatment and Management
- ATP Synthase and ATPases Research
- Peptidase Inhibition and Analysis
- Metabolism and Genetic Disorders
University of Naples Federico II
2015-2023
Federico II University Hospital
2020-2021
Several evidences suggest a marked angiogenic dependency in triple-negative breast cancer (TNBC) tumorigenesis and potential sensitivity to anti-angiogenic agents. Herein, the putative role of Hedgehog (Hh) pathway regulating TNBC-dependent angiogenesis was investigated.Expression regulation Hh transcription factor glioma-associated oncogene homolog1 protein (GLI1) were studied on endothelial compartment TNBC-initiated angiogenesis. To evaluate translational relevance our findings,...
The urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell membrane that focuses urokinase (uPA) proteolytic activity on the surface. Its expression increased in many human cancers, including non-small lung cancer (NSCLC) and colorectal (CRC), correlates with poor prognosis early invasion metastasis. uPAR able to control, through cross-talk tyrosine kinase receptors, shift between tumor dormancy proliferation, usually precedes metastasis formation. Therefore, we...
// Luigi Formisano 1 , Valentina D'Amato Alberto Servetto Simona Brillante Lucia Raimondo Concetta Di Mauro Roberta Marciano Clara Orsini Sandro Cosconati 2 Antonio Randazzo 3 Sarah J. Parsons 4 Nunzia Montuori 5 Bianca Maria Veneziani 6 Sabino De Placido Rosa 1, * Roberto Bianco Department of Clinical Medicine and Surgery, University Naples "Federico II", Naples, Italy DiSTABiF, Second Caserta, Pharmacy, Microbiology, Immunology & Cancer Biology, Center, Virginia Health System,...
Inhibition of the mechanistic target rapamycin (mTOR) is a promising treatment strategy for several cancer types. Rapamycin derivatives such as everolimus are allosteric mTOR inhibitors acting through interaction with intracellular immunophilin FKBP12, prolyl isomerase different cellular functions. Although have significantly improved survival patients, resistance and lack predictive factors response remain unsolved issues. To elucidate mechanisms to everolimus, we evaluated Met activation...
Introduction: Familial hypercholesterolemia (FH) is characterized by extremely high levels of circulating low-density lipoprotein cholesterol (LDL-C) and caused mutations genes involved in LDL-C metabolism, including LDL receptor (LDLR), apolipoprotein B (APOB), or proprotein convertase subtilisin/Kexin type 9 (PCSK9). Accordingly, PCSK9 inhibitors (PCSK9i) are effective reduction. However, no data available on the pleiotropic effect PCSK9i. To this end, we performed an untargeted...
Background and Aims: Familial hypercholesterolemia (FH) is characterized by extremely high levels of circulating low-density lipoprotein cholesterol (LDL-C) caused mutations genes involved in LDL-C metabolism, including LDL receptor (LDLR), Apolipoprotein B (APOB) or Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9). Accordingly, PCSK9 inhibitors (PCSK9i) are effective reduction. However, no data available on pleiotropic effect PCSK9i. To this end we performed an untargeted metabolomics...
Prostate cancer is the most common tumor in men U.S.A. The regulation of growth control normal prostate cells and its contribution to progression a subject intense investigation. Recently our group developed culture techniques that allowed us study neoplastic human epithelial from prostatectomy specimens. Since quantitative evaluation intracellular compartments will be critical defining role membrane trafficking regulation, we used TEM QIAM characterize invivo, as well vitro. This work serve...