A5100637979- Epigenetics and DNA Methylation
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Genetic Associations and Epidemiology
- HIV Research and Treatment
- Bioinformatics and Genomic Networks
- Cancer Research and Treatments
- Birth, Development, and Health
- Air Quality and Health Impacts
- Asthma and respiratory diseases
- Prenatal Substance Exposure Effects
- Energy and Environment Impacts
- Noise Effects and Management
- Hepatitis C virus research
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Ovarian cancer diagnosis and treatment
- Genetic Syndromes and Imprinting
- Allergic Rhinitis and Sensitization
- Toxin Mechanisms and Immunotoxins
- Extracellular vesicles in disease
- Natural product bioactivities and synthesis
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
Second Affiliated Hospital of Jilin University
2017-2025
Nanjing University of Chinese Medicine
2025
Nankai University
2024
Emory University
2018-2024
Vanderbilt University
2024
Fujian Medical University
2024
Education Department of Fujian Province
2024
Case Western Reserve University
2024
VA Tennessee Valley Healthcare System
2024
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2024
In vitro cultured embryogenic callus was employed as a model to investigate microRNAs (miRNAs) associated with embryogenesis and post-embryonic development. Thirty-one miRNAs including 16 novel species were identified from large number of small RNAs which cloned both differentiated undifferentiated rice calli. Four target genes the further validated. A set miRNAs, miR397 miR156, exhibited intriguing expression patterns during transition By exploiting correlations between differential these...
Embryonic stem cells (ESCs) can differentiate into all cell types of the embryonic germ layers. ESCs also generate totipotent 2C-like and trophectodermal cells. However, these latter transitions occur at low frequency due to epigenetic barriers, nature which is not fully understood. Here, we show that treating mouse with sodium butyrate (NaB) increases population enables direct reprogramming trophoblast (TSCs) without a transition through state. Mechanistically, NaB inhibits histone...
There is increasing evidence indicating that air pollution exposure associated with neuronal damage. Since pregnancy a critical window of vulnerability, during this period could have adverse effects on neurodevelopment. This study aims 1) to analyze associations prenatal indoor (particulate matter diameters ≤10 μm, PM
Recent efforts have focused on developing methylation risk scores (MRS), a weighted sum of the individual's DNA (DNAm) values pre-selected CpG sites. Most current MRS approaches that utilize Epigenome-wide association studies (EWAS) summary statistics only include genome-wide significant sites and do not consider co-methylation. New methods relax p-value threshold to more account for inter-correlation DNAm might improve predictive performance MRS. We paired informed co-methylation pruning...
People living with human immunodeficiency virus (HIV) infection have higher risk for chronic kidney disease (CKD), defined by a reduced estimated glomerular filtration rate (eGFR). Previous studies implicated epigenetic changes related to CKD; however, the mechanism of HIV-related CKD has not been thoroughly investigated.We conducted an epigenome-wide association study eGFR among 567 HIV-positive and 117 HIV-negative male participants in Veterans Aging Cohort Study identify signatures...
Abstract Background Epigenomic (e.g., DNA methylation [DNAm]) changes have been hypothesized as intermediate step linking environmental exposures with allergic disease. Associations between individual DNAm at CpGs and diseases reported, but their joint predictive capability is unknown. Methods Data were obtained from 240 children of the German LISA cohort. was measured in blood clots 6 ( N = 234) 10 years 227) using Illumina EPIC chip. Presence aeroallergen sensitization 6, 10, 15 years. We...
Prenatal tobacco exposure (PTE) and prenatal alcohol (PAE) have been associated with an increased risk of delayed neurodevelopment in children as well differential newborn DNA methylation (DNAm). However, the biological mechanisms connecting PTE PAE, DNAm, are largely unknown. Here we aim to determine whether DNAm mediates association between PAE at 6 (N = 112) 24 months 184) from South African Drakenstein Child Health Study. were assessed antenatally using urine cotinine measurements ASSIST...
Atrazine (ATZ) is a triazine herbicide that widely used in agriculture and has been detected surface underground water. Recently, laboratory epidemiological research have found the bioaccumulation of ATZ environment leads to biotoxicity human immune endocrine systems results tumor development.To investigate effects exposure on epithelial ovarian cancer (EOC) cells elucidate potential mechanisms governing these effects.The EOC cell lines Skov3 A2780 were this study explore EOC. The mouse...
Derived from Panax ginseng, the natural product 20(S)-Protopanaxadiol (PPD) has been reported for its cytotoxicity against several cancer cell lines. The molecular mechanism is, however, not well understood. Here we show that PPD significantly inhibits proliferation, induces apoptosis and causes G2/M cycle arrest in human laryngeal carcinoma cells (Hep-2 cells). also decreases levels of proteins related to proliferation. Moreover, PPD-induced is characterized by a dose-dependent...
Extracellular vesicles (EVs) produced by 3D-cultured MSCs can modulate macrophage activation through ANXA1, thereby promoting wound healing.
Laryngeal carcinoma (LC) is one of the most prevalent malignant tumors in head and neck area. Due to its high morbidity mortality, LC poses a serious threat human life health. Even with surgical removal, some patients were not sensitive radiotherapy or experienced transfer recurrence. 20(s)-Protopanaxadiol (PPD), natural product from Panax ginseng, has been reported have cytotoxic effects against several cancer cell lines. However, whether it can improve radiation sensitivity underlying...
The retinoid-interferon-induced mortality-19 (GRIM-19) gene has been identified as a negative regulator associated with tumor development. current study created model of an orthotopically implanted hepatocarcinoma to verify the inhibitory effect GRIM-19 in vivo. After treatment carried by attenuated Salmonella, transplanted tumors were measured Imaging System. expression GRIM-19, Stat3/p-Stat3, cyclinD1, CDK4, PCNA, Bax/Bcl-2, cleaved caspase-9/3, VEGF, and MMP-2/9 was determined using...
Human papillomavirus (HPV) infection is the major etiological factor for cervical cancer. HPV prophylactic vaccines based on L1 virus-like particles have been considered as an effective prevention method. However, existing recombination are too expensive developing countries. DNA might be a lower-cost and alternative. In this study, plasmid (pcDNA3.1-HPV16-L1) co-expressing (pcDNA3.1-HPV16-L1-siE6) carried by attenuated Salmonella were constructed their treatment effect cancer observed,...
Genome-wide association studies (GWAS) of circulating metabolites have revealed the role genetic regulation on human metabolome. Most previous investigations focused European ancestry, and few been conducted among populations African descent living in Africa, where infectious disease burden is high (e.g., immunodeficiency virus (HIV)). It important to understand associations metabolome diverse at-risk including people with HIV (PWH) Africa. After a thorough literature review, reported...