A5052291547- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Children's Rights and Participation
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Biochemical effects in animals
- RNA modifications and cancer
- Neuroendocrine regulation and behavior
- Liver Disease Diagnosis and Treatment
- Prenatal Substance Exposure Effects
- Autism Spectrum Disorder Research
- RNA Research and Splicing
- Regulation of Appetite and Obesity
- Circular RNAs in diseases
Emory University
2019-2021
The University of Texas Southwestern Medical Center
2018
Southwestern Medical Center
2018
Georgia State University
2011-2017
DNA methylation is dynamically modulated during postnatal brain development, and plays a key role in neuronal lineage commitment. This epigenetic mark has also recently been implicated the development of neural sex differences, many which are found hypothalamus. The level depends on balance between placement methyl marks by methyltransferases (Dnmts) their removal, catalyzed ten-eleven translocation (Tet) methylcytosine dioxygenases. Here, we examined developmental changes differences...
Circular RNAs (circRNAs), a class of non-coding generated from non-canonical back-splicing events, have emerged to play key roles in many biological processes. Though numerous tools been developed detect circRNAs rRNA-depleted RNA-seq data based on junction-spanning reads, computational identify critical genomic features regulating circRNA biogenesis are still lacking. In addition, rigorous statistical methods perform differential expression (DE) analysis remain under-developed.We present...
Many of the best-studied neural sex differences relate to in cell number and are due hormonal control developmental death. However, several prominent persist even if death is eliminated. We hypothesized that these may reflect phenotype "decisions" depend on epigenetic mechanisms, such as DNA methylation. To test this, we treated newborn mice with methyltransferase (DNMT) inhibitor zebularine, or vehicle, examined two sexually dimorphic markers at weaning. As expected, males had more cells...
In the current study, we sought to determine significance of ghrelin system in Prader-Willi Syndrome (PWS). PWS is characterized by hypotonia and difficulty feeding neonates hyperphagia obesity beginning later childhood. Other features include low GH, neonatal hypoglycemia, hypogonadism, accelerated mortality. Although have been attributed elevated levels orexigenic hormone ghrelin, this link has never firmly established, nor ghrelin's potentially protective actions increase GH secretion,...
Aberrant neuronal DNA methylation patterns have been implicated in the promotion of obesity development; however, role methyltransferases (Dnmts), enzymes that catalyze methylation, energy balance remains poorly understood. We investigated whether Dnmt1 regulates normal homeostasis and development using a knockout (ND1KO) mouse model, Dnmt1fl/fl Synapsin1Cre, which specifically deletes neurons. Neuronal deficiency reduced adiposity chow-fed mice attenuated high-fat diet (HFD)–fed male mice....