James P. Howard
A5040796476- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Advanced X-ray and CT Imaging
- ECG Monitoring and Analysis
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Sodium Intake and Health
- Hemodynamic Monitoring and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Cardiovascular Syncope and Autonomic Disorders
- Pain Management and Treatment
- Cardiac Structural Anomalies and Repair
- Health Systems, Economic Evaluations, Quality of Life
Imperial College London
2016-2025
Hammersmith Hospital
2017-2025
Imperial College Healthcare NHS Trust
2017-2025
Lung Institute
2015-2025
St George’s University Hospitals NHS Foundation Trust
2024
St George's, University of London
2024
Radiance Technologies (United States)
2023
Baylor Jack and Jane Hamilton Heart and Vascular Hospital
2020-2023
University College London
2022
National Heart Lung and Blood Institute
2022
Background: Ischemic heart disease (IHD) has been considered the top cause of mortality globally. However, countries differ in their rates and there have changes over time. Methods Results: We analyzed data submitted to World Health Organization from 2005 2015 by individual countries. explored patterns relationships with age, sex, income calculated age-standardized for each country addition crude death rates. In 5 illustrative which provided detailed data, we trends IHD 3 noncommunicable...
His bundle pacing is a new method for delivering cardiac resynchronization therapy (CRT). The authors performed head-to-head, high-precision, acute crossover comparison between and conventional biventricular CRT, measuring effects on ventricular activation hemodynamic function. Patients with heart failure left branch block referred CRT were recruited. Using noninvasive epicardial electrocardiographic imaging, the identified patients in whom shortened time. In these patients, compared of...
Most people who begin statins abandon them, most commonly because of side effects.The purpose this study was to assess daily symptom scores on statin, placebo, and no treatment in participants had abandoned statins.Participants received 12 1-month medication bottles, 4 containing atorvastatin 20 mg, empty. We measured intensity for each using an app (scale 1-100). also the "nocebo" ratio: ratio symptoms induced by taking statin that placebo.A total 60 were randomized 49 completed 12-month...
Percutaneous coronary intervention (PCI) is frequently performed to reduce the symptoms of stable angina. Whether PCI relieves angina more than a placebo procedure in patients who are not receiving antianginal medication remains unknown. We conducted double-blind, randomized, placebo-controlled trial with Patients stopped all medications and underwent 2-week symptom assessment phase before randomization. were then randomly assigned 1:1 ratio undergo or followed for 12 weeks. The primary end...
BackgroundThe coronary sinus reducer (CSR) is proposed to reduce angina in patients with stable artery disease by improving myocardial perfusion. We aimed measure its efficacy, compared placebo, on ischaemia reduction and symptom improvement.MethodsORBITA-COSMIC was a double-blind, randomised, placebo-controlled trial conducted at six UK hospitals. Patients aged 18 years or older angina, disease, ischaemia, no further options for treatment were eligible. All completed quantitative...
Ischaemic heart disease (IHD) is the leading cause of death worldwide and its prevention a public health priority.We analysed IHD mortality data from World Health Organisation as February 2014 by country, age income. Age-standardised rates country were calculated. We constructed cartogram which an algorithmically transformed world map that conveys numbers deaths in form spatial area.Of countries provided data, Russia, United States America Ukraine contributed largest deaths. India China...
Background: The multicenter, international, randomized, blinded, sham-controlled RADIANCE-HTN SOLO trial (A Study of the ReCor Medical Paradise System in Clinical Hypertension) demonstrated a 6.3 mm Hg greater reduction daytime ambulatory systolic blood pressure (BP) at 2 months by endovascular ultrasound renal denervation (RDN) compared with sham procedure among patients not treated antihypertensive medications. We report 6-month results after addition recommended standardized stepped-care...
In this study, a systematic analysis was conducted of phasic intracoronary pressure and flow velocity in patients with severe aortic stenosis (AS) coronary artery disease, undergoing transcatheter valve replacement (TAVR), to determine how AS affects: 1) flow; 2) hyperemic 3) the most common clinically used indices severity, instantaneous wave-free ratio fractional reserve. A significant proportion have concomitant disease. The effect on pressure, flow, established invasive clinical severity...
Background: There are no data on how fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) associated with the placebo-controlled efficacy of percutaneous coronary intervention (PCI) in stable single-vessel artery disease. Methods: We report association between prerandomization invasive physiology within ORBITA (Objective Randomised Blinded Investigation With Optimal Medical Therapy Angioplasty Stable Angina), a trial patients who have angina angiographically severe disease...