A5018394761- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Tissue Engineering and Regenerative Medicine
- Peripheral Artery Disease Management
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Pluripotent Stem Cells Research
- Pain Management and Treatment
- Heart Failure Treatment and Management
- Vascular Procedures and Complications
University Hospital Southampton NHS Foundation Trust
2023-2024
University of Southampton
2023-2024
Imperial College London
2014-2023
Harefield Hospital
2023
National Health Service
2023
Imperial College Healthcare NHS Trust
2011-2022
Hammersmith Hospital
2015-2022
San Raffaele University of Rome
2015-2019
Imperial Valley College
2014-2019
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017-2019
The purpose of this study was to develop an adenosine-independent, pressure-derived index coronary stenosis severity.Assessment severity with fractional flow reserve (FFR) requires that resistance is stable and minimized. This usually achieved by administration pharmacological agents such as adenosine. In 2-part study, we determine whether there a time when naturally minimized at rest assess the diagnostic efficiency, compared FFR, new adenosine-free over time.A total 157 stenoses were...
The population of adults with congenital heart disease (ACHD) is growing and ageing. Limited information about the diagnostic spectrum this emerging population, its resource utilization at tertiary ACHD centres, especially prognostic parameters available. Retrospective cohort study on all patients ≥60 years age under active follow-up. All-cause mortality was primary outcome measure. Out a total 7315 patients, 375 [190 females (50.7%), mean 64.8 ± 5.9 years] fulfilled inclusion criteria....
Tissue engineering offers an exciting possibility for cardiac repair post myocardial infarction. We assessed the effects of combined polyethylene glycol hydrogel (PEG), human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM), and erythropoietin (EPO) therapy in a rat model PEG with/out iPSC-CMs EPO; saline; or saline alone was injected into infarcted hearts shortly after Injection almost any combination therapeutics limited acute elevations chamber volumes. After 10 weeks,...
Objectives To understand the impact of COVID-19 on delivery and outcomes primary percutaneous coronary intervention (PPCI). Furthermore, to compare clinical presentation patients with ST-segment elevation myocardial infarction (STEMI) active against those without COVID-19. Methods We systematically analysed 348 STEMI cases presenting PPCI programme in London during peak pandemic (1 March 30 April 2020) compared 440 from same period 2019. Outcomes interest included ambulance response times,...
Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to regulation structure and function. We investigated role stimulation preventing culture-induced adult using rat, rabbit human heart failure myocardial slices. Here we report that application preload equivalent sarcomere length (SL) = 2.2 μm optimal for maintenance rat slice structural, functional...
Objectives Coronary stent underexpansion is a known risk factor for in‐stent restenosis and thrombosis. There are limited options once noncompliant balloons have failed to achieve optimal expansion. Excimer Laser Angioplasty with contrast medium injection one possibility, but not readily available. Rotational atherectomy an alternative, has been described in case reports, concerns exist regarding safety. Methods All consecutive patients undergoing rotational symptomatic due resistant balloon...
Abstract Aims Takotsubo syndrome (TTS) is an acute heart failure, typically triggered by high adrenaline during physical or emotional stress. It distinguished from myocardial infarction (MI) a characteristic pattern of ventricular basal hypercontractility with hypokinesis apical segments, and in the absence culprit coronary occlusion. We aimed to understand whether recently discovered circulating biomarkers miR-16 miR-26a, which differentiate TTS MI at presentation, were mechanistically...
It has become apparent that, in comparison to metallic stents, bioresorbable vascular scaffolds (BVS) require specific implantation techniques. The aim of this study was investigate outcomes following BVS using a dedicated strategy for optimal deployment.Four hundred consecutive lesions (264 patients) treated with the Absorb were analysed. All procedures performed based on principles: 1) aggressive lesion preparation; 2) high-pressure post-dilation; and 3) low threshold intravascular...
Abstract Aims Conflicting data exist supporting differing mechanisms for sustaining ventricular fibrillation (VF), ranging from disorganized multiple-wavelet activation to organized rotational activities (RAs). Abnormal gap junction (GJ) coupling and fibrosis are important in initiation maintenance of VF. We investigated whether patterns the degree GJ affected underlying VF mechanism. Methods results Optical mapping 65 Langendorff-perfused rat hearts was performed study control with acute...
Engineered heart tissue (EHT) strategies, by combining cells within a hydrogel matrix, may be novel therapy for failure. EHTs restore cardiac function in rodent injury models, but more data are needed clinically relevant settings. Accordingly, an upscaled EHT patch (2.5 cm × 1.5 mm) consisting of up to 20 million human induced pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) embedded fibrin-based was developed. A rabbit myocardial infarction model then established test feasibility and...
Cardiac remodelling is the process by which heart adapts to its environment. Mechanical load a major driver of remodelling. tissue culture has been frequently employed for in vitro studies load-induced remodelling; however, current protocols (e.g. cyclic stretch, isometric load, and auxotonic load) are oversimplified do not accurately capture dynamic sequence mechanical conformational changes experienced vivo. This limits translational scope relevance findings.We developed novel methodology...
Objectives The clinical impact of SARS-CoV-2 has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development complications in initial cohort positive patients at Imperial College Healthcare National Health Service Trust, UK. Methods retrospectively analysed 498 COVID-19 adult admissions to our institute from 7 March April 2020. Patient data were collected for baseline demographics, comorbidities outcomes,...
Objective International guidelines recommend the use of dual antiplatelet therapy (DAPT) after transcatheter aortic valve implantation (TAVI). The recommended duration DAPT varies between guidelines. In this two-part study, we (1) performed a structured survey 45 TAVI centres from around world to determine if there is consensus among clinicians regarding TAVI; and then (2) systematic review all suitable studies (randomised controlled trials (RCTs) registries) aspirin monotherapy can be used...