A5086791057- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Neuroscience of respiration and sleep
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- COVID-19 and healthcare impacts
- Sinusitis and nasal conditions
- Ion channel regulation and function
- Hip and Femur Fractures
- Oral and Maxillofacial Pathology
- Sulfur Compounds in Biology
- Head and Neck Surgical Oncology
- Hip disorders and treatments
- Ultrasound in Clinical Applications
- Bone and Joint Diseases
- Cardiac Ischemia and Reperfusion
- Liver Disease and Transplantation
- Vascular Anomalies and Treatments
- Burn Injury Management and Outcomes
- Injury Epidemiology and Prevention
- Coronary Artery Anomalies
- Protein Kinase Regulation and GTPase Signaling
- Connective Tissue Growth Factor Research
St George’s University Hospitals NHS Foundation Trust
2020-2021
St George's Hospital
2020
King's College London
2006-2017
Antrim Area Hospital
2017
Royal Free London NHS Foundation Trust
2013-2017
The Royal Free Hospital
2012
University College London
2012
St Thomas' Hospital
2012
King's College Hospital
2012
Connolly Hospital Blanchardstown
2009
Objectives To understand the impact of COVID-19 on delivery and outcomes primary percutaneous coronary intervention (PPCI). Furthermore, to compare clinical presentation patients with ST-segment elevation myocardial infarction (STEMI) active against those without COVID-19. Methods We systematically analysed 348 STEMI cases presenting PPCI programme in London during peak pandemic (1 March 30 April 2020) compared 440 from same period 2019. Outcomes interest included ambulance response times,...
A retrospective review was performed to determine the outcome after cardiac operations in patients with a documented history of noncardiac cirrhosis.The charts admitted cardiothoracic surgical service between 1990 and 1996 were reviewed, 13 preoperative cirrhosis identified. The severity liver disease graded according criteria Child.Most cases alcohol-related. Eight classified as having Child class 5 B cirrhosis. One hundred percent 25% those had major complications. postoperative chest tube...
The roles of voltage-gated (K(V)) and large conductance Ca2+-activated K+ (BK(Ca)) channels in regulating basal contractility myometrial smooth muscle are unresolved. aim this study was to determine the effects inhibition these on spontaneous rhythmic contraction strips from four groups rats: nonpregnant during early (day 7), mid- 14), late 21) pregnancy. BK(Ca) were inhibited using iberiotoxin (1-100 nM), paxilline (1-10 microM) or penitrem A (1-500, 3000 nM); K(V) tetraethylammonium (TEA;...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Hypoxic pulmonary vasoconstriction (HPV) maintains blood oxygenation during acute hypoxia but contributes to hypertension chronic hypoxia. The mechanisms of HPV remain controversial, in part because is usually studied the presence agonist-induced preconstriction ('pretone'). This potentiates may obscure and distort its underlying mechanisms. We therefore carried out an extensive assessment proposed contributing isolated intrapulmonary arteries (IPAs) absence pretone by using a conventional...
SSc-pulmonary arterial hypertension (SSc-PAH) is associated with worse response to therapy and survival when compared idiopathic PAH. It suggested that the vasculopathy in SSc may involve postcapillary pulmonary venules resulting veno-occlusive disease (PVOD). This underlie lower gas transfer outcome on therapy. We sought test whether CT signs of PVOD (CTS-PVOD) were frequent SSc-PAH they oedema survival.CT thorax 66 patients precapillary (PH) blindly scored by two radiologists for CTS-PVOD...
Application of H 2 S (“sulfide”) elicits a complex contraction in rat pulmonary arteries (PAs) comprising small transient (phase 1; Ph1) followed by relaxation and then second, larger, more sustained 2; Ph2). We investigated the mechanisms causing this response using isometric myography second-order PAs, with Na as sulfide donor. Both phases to 1,000 μM were attenuated pan-PKC inhibitor Gö6983 (3 μM) 50 ryanodine; Ca 2+ channel blocker nifedipine (1 was without effect. Ph2 mitochondrial III...
Dyspnoea on exertion, impaired exercise tolerance, and fatigue are most often due to common cardiac pulmonary diseases such as heart failure or COPD, but may be also hypertension, a pathophysiological state of diverse aetiology that is frequently misdiagnosed recognised late. Pulmonary hypertension has poor prognosis; patients take long time present appropriate referral treatment can delayed.1 Pulmonary an umbrella term which describes characterised by the elevation artery pressure (PAP)....
We assessed the roles of Ca 2+ release, electron transport chain and NOX in hypoxic pulmonary vasoconstriction (HPV), process by which hypoxia constricts arteries (PA). HPV absence pretone 2 nd 3 rd order rat PA branches gassed with 95% N , 5% CO for 40 min demonstrated an initial transient tension increase (phase 1) followed a slow rise 2). Phase 1 was abolished but phase unaffected complex I inhibitor rotenone (1 μM). Both phases were IV cyanide (10 Pretreatment superoxide dismutase (200...
The gas H 2 S (sulfide) causes a biphasic contraction of unknown mechanism in pulmonary arteries (PA). We assessed this rings rat nd order PA using myography to measure tension and NaHS as source sulfide. Reactive oxygen species (ROS) levels the mitochondrial membrane potential (Δψ) were recorded indicators LO12 TMRE, respectively. (500μM) evoked small then much larger which gradually relaxed. was strongly reduced by 10μg/ml antimycin (AM) 50μM dantrolene but unaffected 1μM rotenone (ROT)....
Abstract Background Kawasaki disease is the leading cause of premature coronary artery in developed countries. As such, patients may require revascularisation as children. However, there are no randomized data guiding treatment so this must be individualized. This case report describes decision-making a young patient requiring revascularization who had already suffered stent occlusion. Case summary Our patient, 16-year-old boy with disease, presented cardiac arrest during exercise. Coronary...
Abstract Background The impact of COVID‐19 on the diagnosis and management nonculprit lesions remains unclear. Objectives This study sought to evaluate outcomes patients with during pandemic. Methods We conducted a retrospective observational analysis consecutive primary percutaneous coronary intervention (PPCI) pathway activations across heart attack center network in London, UK. Data from period 2020 were compared prepandemic data 2019. outcome was rate lesion (PCI) secondary included...
Pulmonary hypertension is associated with vasoconstriction, thrombosis and proliferation, the lack of endogenous prostacyclin. Prostacyclin its analogues are potent vasodilators, representing an important pillar modern therapy this devastating disease. Potassium channels determine membrane potential pulmonary artery smooth muscle cells (PASMCs) controllers their calcium homeostasis consequently arterial tone. In present study, we investigated signaling pathway effects stable prostacyclin...