A5101899603- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Radiation Therapy and Dosimetry
- Pluripotent Stem Cells Research
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- 3D Printing in Biomedical Research
- COVID-19 Clinical Research Studies
- Glioma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Cardiac electrophysiology and arrhythmias
- Ferroelectric and Piezoelectric Materials
- COVID-19 and healthcare impacts
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Radiation Detection and Scintillator Technologies
- Laser Material Processing Techniques
- Cardiomyopathy and Myosin Studies
- Electrospun Nanofibers in Biomedical Applications
- Low-power high-performance VLSI design
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Advances in Oncology and Radiotherapy
Imperial College London
2017-2024
Intel (United States)
2007-2024
Imperial College Healthcare NHS Trust
2020-2023
Cornell University
2023
Cerner (United States)
2023
King's College London
2022
Lung Institute
2022
University of California, San Francisco
2021
Hammersmith Hospital
2019-2021
Yale University
2009-2021
The introduction of advanced techniques and technology in radiotherapy has greatly improved our ability to deliver highly conformal tumor doses while minimizing the dose adjacent organs at risk. Despite these tremendous improvements, there remains a general concern about normal tissues that are not target radiation treatment; any "nontarget" should be minimized as it offers no therapeutic benefit. As patients live longer after treatment, is increased opportunity for late effects including...
Digital devices are the essential building blocks of any modern electronic system. Fibres containing digital could enable fabrics with system capabilities for applications in physiological monitoring, human-computer interfaces, and on-body machine-learning. Here, a scalable preform-to-fibre approach is used to produce tens metres flexible fibre hundreds interspersed, temperature sensors memory density ~7.6 × 10
<h3>Objectives</h3> To compare health-related quality of life (HRQoL) before and after treatment with etanercept in patients moderate to severe rheumatoid arthritis (RA), psoriatic (PsA) psoriasis using spydergram representations. <h3>Methods</h3> Data from randomised, controlled trials RA, PsA were analysed. HRQoL was assessed by the medical outcomes survey short form 36 (SF-36) physical (PCS) mental (MCS) component summary domain scores. Baseline comparisons age gender-matched norms...
Novel coronavirus disease 2019 (COVID-19) is a highly infectious, rapidly spreading viral with an alarming case fatality rate up to 5%. The risk factors for severe presentations are concentrated in patients chronic kidney disease, particularly end-stage renal (ESRD) who dialysis dependent. We report the first US of 56-year-old nondiabetic male ESRD secondary IgA nephropathy undergoing thrice-weekly maintenance hemodialysis 3 years, developed COVID-19 infection. He has hypertension controlled...
To accurately segment pathological and healthy lungs for reliable computer-aided disease diagnostics, a stack of chest CT scans is modeled as sample spatially inhomogeneous joint 3D Markov-Gibbs random field (MGRF) voxel-wise lung image signals (intensities). The proposed learnable MGRF integrates two visual appearance sub-models with an adaptive shape submodel. first-order submodel accounts both the original its Gaussian scale space (GSS) filtered version to specify local global signal...
Objectives To understand the impact of COVID-19 on delivery and outcomes primary percutaneous coronary intervention (PPCI). Furthermore, to compare clinical presentation patients with ST-segment elevation myocardial infarction (STEMI) active against those without COVID-19. Methods We systematically analysed 348 STEMI cases presenting PPCI programme in London during peak pandemic (1 March 30 April 2020) compared 440 from same period 2019. Outcomes interest included ambulance response times,...
The ability to manipulate cellular organization within soft materials has important potential in biomedicine and regenerative medicine; however, it often requires complex fabrication procedures. Here, a simple, cost-effective, one-step approach that enables the control of cell orientation 3D collagen hydrogels is developed dynamically create various tailored microstructures cardiac tissues. This achieved by incorporating iron oxide nanoparticles into human cardiomyocytes applying short-term...
Cancer patients undergoing radiation treatment are exposed to high doses the target (tumour), intermediate adjacent tissues and low from scattered all parts of body. In case proton therapy, secondary neutrons generated in accelerator head inside patient reach many areas Due improved efficacy management cancer patients, number long term survivors post-radiation is increasing substantially. This results concern about risk radiation-induced appearing at late post-treatment times. paper presents...
This retrospective review evaluated the efficacy and toxicity profiles of various dose fractionations using hypofractionated stereotactic radiotherapy (HSRT) in treatment brain metastases.Between 2004 2007, 36 patients with 66 metastases were treated HSRT. Nine these subjects excluded because absence post-treatment magnetic resonance imaging scans, resulting 27 a total 52 lesions. Of lesions, 45 lesions whole-brain plus HSRT boost 7 as primary treatment. The median prescribed was 25 grays...
Development of low cost, easy-to-use chemical sensor systems for dose detection γ radiation remains highly desired medical therapy and nuclear security monitoring. We report herein on a new fluorescence molecule, 4,4'-di(1H-phenanthro[9,10-d]imidazol-2-yl)biphenyl (DPI-BP), which can be dissolved into halogenated solvents (e.g., CHCl3, CH2Cl2) to enable instant down the 0.01 Gy level. The sensing mechanism is primarily based induced quenching DPI-BP. Pristine DPI-BP strongly fluorescent in...
Normal brain tissue doses have been shown to be strongly apparatus dependent for multi-target stereotactic radiosurgery. In this study, we investigated whether inter-target dose interplay effects across contemporary radiosurgical treatment platforms are responsible such an observation.For the subsets ([Formula: see text] and 12) of a total 12 targets were planned at six institutions. Treatment included (1) Gamma Knife Perfexion (PFX), (2) CyberKnife, (3) Novalis linear accelerator equipped...
Abstract Aims Takotsubo syndrome (TTS) is an acute heart failure, typically triggered by high adrenaline during physical or emotional stress. It distinguished from myocardial infarction (MI) a characteristic pattern of ventricular basal hypercontractility with hypokinesis apical segments, and in the absence culprit coronary occlusion. We aimed to understand whether recently discovered circulating biomarkers miR-16 miR-26a, which differentiate TTS MI at presentation, were mechanistically...
Engineered heart tissue (EHT) strategies, by combining cells within a hydrogel matrix, may be novel therapy for failure. EHTs restore cardiac function in rodent injury models, but more data are needed clinically relevant settings. Accordingly, an upscaled EHT patch (2.5 cm × 1.5 mm) consisting of up to 20 million human induced pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) embedded fibrin-based was developed. A rabbit myocardial infarction model then established test feasibility and...
Objectives The clinical impact of SARS-CoV-2 has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development complications in initial cohort positive patients at Imperial College Healthcare National Health Service Trust, UK. Methods retrospectively analysed 498 COVID-19 adult admissions to our institute from 7 March April 2020. Patient data were collected for baseline demographics, comorbidities outcomes,...
Previous studies indicate cardiovascular health benefits of cranberry juice consumption.
In this study, we report static and perfused models of human myocardial-microvascular interaction. culture, observe distinct regulation electrophysiology induced pluripotent stem cell derived-cardiomyocytes (hiPSC-CMs) in co-culture with cardiac microvascular endothelial cells (hCMVECs) left ventricular fibroblasts (hLVFBs), including modification beating rate, action potential, calcium handling, pro-arrhythmic substrate. Within a heart-on-a-chip model, subject three-dimensional (3D) to...
Technical improvements in commercially available radiosurgery platforms have made it practical to treat a large number of intracranial targets. The goal this study was investigate whether the dose normal brain when planning multiple targets is apparatus dependent.The authors selected single case involving patient with 12 metastatic lesions widely distributed throughout as visualized on contrast-enhanced CT. Target volumes and critical structures were delineated Leksell Gamma Knife Perfexion...
This paper proposes a novel framework for the classification of lung nodules using computed tomography (CT) scans. The proposed is based on integrating following features to get accurate diagnosis detected nodules: (i) Spherical Harmonics-based shape that have ability describe complexity nodules; (ii) Higher-Order Markov Gibbs Random Field (MGRF)-based appearance model has spatial inhomogeneities in nodule; and (iii) volumetric size nodules. To accurately surface/shape detect nodules, we...
In 2011, IBM's supercomputer Watson defeated the former human winners and won first prize on Jeopardy! game. It has created an overly publicized attention machine learning Artificial Intelligence (AI). Early this year, Google AlphaGo marked a major breakthrough in AI by winning game against world's best champion player most complex game, ancient Chinese Go With no doubt, interests its related products had reached global frenzy. As scientists advance technology, concern of job security risen...