A5048250547- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Interventions and Diagnostics
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Cardiac Fibrosis and Remodeling
- Atrial Fibrillation Management and Outcomes
- Cardiac Ischemia and Reperfusion
- Tracheal and airway disorders
- Autoimmune Neurological Disorders and Treatments
- Trauma Management and Diagnosis
- Cardiomyopathy and Myosin Studies
- Mechanical Circulatory Support Devices
- Shoulder and Clavicle Injuries
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- COVID-19 and healthcare impacts
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Hammersmith Hospital
2012-2022
Imperial College Healthcare NHS Trust
2012-2022
Imperial College London
2010-2022
NIHR Imperial Biomedical Research Centre
2021-2022
Medical University of South Carolina
2022
Hofstra University
2019-2021
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2018-2021
San Raffaele University of Rome
2016
Chukwuemeka Odumegwu Ojukwu University
2012
Lung Institute
2010-2011
Right ventricular (RV) long-axis function is known to be depressed after cardiac surgery, but the mechanism not known. We hypothesized that intraoperative transesophageal echocardiography could pinpoint time at which this happens help narrow range of plausible mechanisms. Transthoracic was conducted in 33 patients before and elective coronary artery bypass graft. In an intensively monitored cohort 9 patients, we also RV intraoperatively using serial pulsed wave tissue Doppler (PW TD)...
In this study, a systematic analysis was conducted of phasic intracoronary pressure and flow velocity in patients with severe aortic stenosis (AS) coronary artery disease, undergoing transcatheter valve replacement (TAVR), to determine how AS affects: 1) flow; 2) hyperemic 3) the most common clinically used indices severity, instantaneous wave-free ratio fractional reserve. A significant proportion have concomitant disease. The effect on pressure, flow, established invasive clinical severity...
Aortic stenosis causes angina despite unobstructed arteries. Measurement of conventional coronary hemodynamic parameters in patients undergoing valvular surgery has failed to explain these symptoms. With the advent percutaneous aortic valve replacement (PAVR) and developments pulse wave analysis, it is now possible instantaneously abolish measure resulting changes waves that direct flow.Intracoronary pressure flow velocity were measured immediately before after PAVR 11 with Using we...
Objectives The clinical impact of SARS-CoV-2 has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development complications in initial cohort positive patients at Imperial College Healthcare National Health Service Trust, UK. Methods retrospectively analysed 498 COVID-19 adult admissions to our institute from 7 March April 2020. Patient data were collected for baseline demographics, comorbidities outcomes,...
Accurate prediction, early detection and treatment of acute kidney injury (AKI) are essential for improving post-operative outcomes. This study aimed to examine the role aortic stiffness neutrophil gelatinase-associated lipocalin (NGAL) as predictors AKI or need medical renal intervention following valve replacement (AVR). Aortic pulse wave velocity plasma NGAL were measured pre-operatively in recruited patients undergoing AVR stenosis (AS). Plasma was also at 3 18–24 hours after...
Patients with severe aortic stenosis (AS) often have coronary artery disease. Both the valve and disease influence blood flow to myocardium its ability respond stress; leading exertional symptoms. In this study, we aim quantify effect of AS on microcirculation determine if is influenced by any concomitant We then compare stenoses microcirculation.Group 1: 55 patients intermediate treated transcatheter implantation (TAVI) were included. Group 2: 85 no percutaneous intervention Coronary...
The natural history of aortic valve disease associated with ventricular dysfunction is dismal. Aortic replacement (AVR) increased mortality in patients left and the long-term outcome these not well-known. We evaluated perioperative outcomes results impaired systolic function undergoing AVR.Retrospective analysis identified 132 consecutive a ejection fraction (LVEF)<40% who underwent AVR or without concomitant coronary artery bypass grafting (CABG) between 1990 2003. Patients other pathology...
Propofol-induced metabolic acidosis is well recognised in the paediatric literature, but existence of such a syndrome adults remains contentious. In most reported cases, complicated prolonged administration propofol critically ill patients. We present case severe non-fatal reversible acidosis, without ventilatory depression or hypoxia, related to short-term infusion an adult during and after coronary artery bypass grafting. suggest that lactic occurred genetically susceptible patient with...
To determine the effect of procedural and clinical factors upon C reactive protein (CRP) dynamics following transcatheter aortic valve implantation (TAVI).Two hundred eight consecutive patients that underwent transfemoral TAVI at two hospitals (Imperial, College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom San Raffaele Scientific Institute, Milan, Italy) were included. Daily venous plasma CRP levels measured for up to 7 d procedure (or discharge). Procedural 30-d safety...
The mediastinal structures said to lie on a horizontal plane at the level of manubriosternal joint (manubriosternal plane) in cadaver include bifurcation trachea, concavity arch aorta, and azygos vein as it arches over right principal bronchus enter superior vena cava. We have reviewed CT scans thorax 51 subjects determine 1) whether these consistently this living 2) vertebral plane. found that trachea lay 41% subjects, passed through aorta 49% that, although there was notable individual...
Paraneoplastic neurological syndromes are conditions that manifest as the remote effects of cancer. These very rare, occurring in 1/10000 patients with a malignancy, and include Lambert-Eaton myasthenic syndrome, limbic encephalitis, subacute cerebellar ataxia, opsoclonus-myoclonus, Stiff-Person Syndrome, retinopathies, chronic gastrointestinal pseudo-obstruction sensory neuropathy. This report describes case 41-year-old man who presented elements multiple paraneoplastic syndromes, including...
Abstract Aim Severe aortic stenosis frequently involves the development of left ventricular hypertrophy (LVH) creating a dichotomous haemodynamic state within coronary circulation. Whilst increased force contraction enhances its resultant relaxation and thus increases distal diastolic “suction” force, presence LVH has potentially opposing effect on ventricular‐coronary interplay. The aim this study was to use non‐invasive wave intensity analysis (WIA) separate measure sequential effects...
Background. Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic measured by pulse wave velocity (PWV) and serum ischemic injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in valve replacement has not been assessed. Methods. Patients undergoing (AVR) for stenosis (AS) had their PWV NR2Ab preoperatively. We analyzed two ways: (1) continuous variables...