A5008993177- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Aortic aneurysm repair treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pluripotent Stem Cells Research
- Coronary Interventions and Diagnostics
- Cardiac Arrest and Resuscitation
- Abdominal Trauma and Injuries
- Immune Response and Inflammation
- Surgical site infection prevention
- Trauma and Emergency Care Studies
- Cardiac tumors and thrombi
- Anesthesia and Neurotoxicity Research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Imaging and Diagnostics
- Pericarditis and Cardiac Tamponade
- Fatty Acid Research and Health
Imperial College London
2009-2020
St. Mary's Hospital
2010-2020
St Mary's Hospital
2010-2020
St Mary's Hospital
2017
St Mary's Hospital
2009-2014
Imperial College Healthcare NHS Trust
2011-2014
Hammersmith Hospital
2013-2014
Tissue engineering offers an exciting possibility for cardiac repair post myocardial infarction. We assessed the effects of combined polyethylene glycol hydrogel (PEG), human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM), and erythropoietin (EPO) therapy in a rat model PEG with/out iPSC-CMs EPO; saline; or saline alone was injected into infarcted hearts shortly after Injection almost any combination therapeutics limited acute elevations chamber volumes. After 10 weeks,...
Accurate prediction, early detection and treatment of acute kidney injury (AKI) are essential for improving post-operative outcomes. This study aimed to examine the role aortic stiffness neutrophil gelatinase-associated lipocalin (NGAL) as predictors AKI or need medical renal intervention following valve replacement (AVR). Aortic pulse wave velocity plasma NGAL were measured pre-operatively in recruited patients undergoing AVR stenosis (AS). Plasma was also at 3 18–24 hours after...
Cardiac function and myocardial strain are affected by cardiac afterload, which is in part due to the stiffness of aortic wall. In this study, we hypothesize that pulse wave velocity (PWV) as a marker correlates with conventional clinical biochemical markers perioperative valve replacement (AVR). Patients undergoing AVR for stenosis between June 2010 August 2012 were recruited inclusion study. PWV, NYHA class left ventricular (LV) assessed pre-operatively. PWV was analysed both continuous...
Conventional cardiopulmonary bypass causes haemodilution and is a trigger of systemic inflammatory reactions, coagulopathy organ failure. Miniaturized has been proposed as way to reduce these deleterious effects conventional promote more physiological state. The use miniaturized reported in low-risk patients undergoing valve coronary artery graft (CABG) surgery. However, little known about its application major aortic surgery.From February 2007 September 2010, 49 underwent surgery using the...
The evaluation of any new cardiac valvular prosthesis should go beyond the classical morbidity and mortality rates involve hemodynamic assessment. As a proof concept, objective this study was to characterise for first time hemodynamics blood flow profiles at aortic root in patients implanted with BioValsalva™ composite valve-conduit using comprehensive MRI computer technologies. Four male 2 age-matched normal controls (NC) underwent magnetic resonance imaging (MRI). Phase-contrast...
Cardiac surgery can lead to post-operative end-organ complications secondary activation of systemic inflammatory response. We hypothesize that surgical trauma or cardiopulmonary bypass (CPB) may initiate response via release mitochondrial DNA (mtDNA) signaling Toll-like receptor 9 (TLR9) and interleukin-6 production (IL-6).The role TLR9 in cardiac was studied using a murine model sternotomy porcine CPB. mtDNA IL-6 were measured with without TLR9-antagonist treatment. To study...
Abstract Prosthetic aortic valve dysfunction presenting as regurgitation is a complication of mechanical replacement. We describe case late caused by an annular suture excessive length obstructing the closure mechanism bileaflet prosthetic valve. present this rare cause in 80-year-old male patient who presented with haemolysis and dyspnoea. At time operation it was found that long vertically positioned interfering normal one leaflets causing eccentric jets. These findings were misdiagnosed...