A5054084038- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Blood transfusion and management
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Anesthesia and Neurotoxicity Research
- Aortic aneurysm repair treatments
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac and Coronary Surgery Techniques
- Intensive Care Unit Cognitive Disorders
- Hip and Femur Fractures
- Acute Kidney Injury Research
- Venous Thromboembolism Diagnosis and Management
- Spine and Intervertebral Disc Pathology
- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- Hemophilia Treatment and Research
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Sepsis Diagnosis and Treatment
- Uterine Myomas and Treatments
- Clinical practice guidelines implementation
- Blood Pressure and Hypertension Studies
University of Toronto
2011-2024
Toronto General Hospital
2011-2024
University Health Network
2010-2024
St. Michael's Hospital
2009-2016
St Michaels Hospital
2012-2016
University Medical Center Utrecht
2016
Institute for Clinical Evaluative Sciences
2012-2015
Canadian Institutes of Health Research
2007-2015
Committee on Publication Ethics
2015
American Society of Anesthesiologists
2015
Preoperative anemia is an important risk factor for perioperative red blood cell transfusions and has been shown to be independently associated with adverse outcomes after noncardiac surgery. The objective of this observational study was measure the prevalence preoperative assess relationship between postoperative mortality.Data were retrospectively collected on 7,759 consecutive surgical patients at University Health Network 2003 2006. defined as a hemoglobin concentration less than 12.0...
Postoperative myocardial injury occurs frequently after noncardiac surgery and is strongly associated with mortality. Intraoperative hypotension (IOH) hypothesized to be a possible cause. The aim of this study was determine the association between IOH postoperative injury.This cohort included 890 consecutive patients aged 60 yr or older undergoing vascular from two university centers. occurrence assessed by troponin measurements as part care protocol. defined four different thresholds using...
Background Delirium is an acute deterioration of brain function characterized by fluctuating consciousness and inability to maintain attention. Use statins has been shown decrease morbidity mortality after major surgical procedures. The objective this study was determine association between preoperative administration postoperative delirium in a large prospective cohort patients undergoing cardiac surgery with cardiopulmonary bypass. Methods After Institutional Review Board approval, data...
In a randomized study of 128 patients, we evaluated intermittent pneumatic compression the calf in prevention leg scan-detected venous thrombosis intracranial disease. Pneumatic for 5 days reduced rate from 12 63 control patients (19.1 percent) to one 65 (1.5 given prophylaxis (p = 0.00082). who had craniotomy brain tumor, subarachnoid hemorrhage, or subdural hematomas, incidence nine 49 (18.4 53 (1.9 0.0051). remained at risk after days, was no different group than that received prophylaxis.
Abstract Background: Perioperative metoprolol increases postoperative stroke. Animal studies indicate that the mechanism may be related to attenuated β2-adrenoreceptor-mediated cerebral vasodilatation. The authors therefore conducted a cohort study whether highly β1-specific β-blocker (bisoprolol) was associated with reduced risk of stroke compared less selective β-blockers (metoprolol or atenolol). Methods: single-center on 44,092 consecutive patients age 50 yr more having noncardiac,...
The added value of a preoperative electrocardiogram (ECG) in the prediction postoperative myocardial infarction (POMI) and death was compared with clinical risk factors identified from patient's history.An ECG is frequently performed before surgery to screen for asymptomatic coronary artery disease. However, abnormalities predict POMI has been questioned.The study included 2967 noncardiac patients >50 years age 2 university hospitals, who were expected stay hospital >24 hours. All data...
: Acute kidney injury (AKI) is a serious complication of cardiac surgery, and preoperative anemia perioperative erythrocyte transfusion are important risk factors. Prophylactic in anemic patients may, therefore, protect against AKI.: In this unblinded, parallel-group, randomized pilot trial, 60 (hemoglobin 10-12 g/dL) undergoing surgery with cardiopulmonary bypass were (1:1) to prophylactic (2 units erythrocytes transfused 1 2 days before (n = 29) or standard care (transfusions as indicated;...
Tranexamic acid (TXA) is a common antifibrinolytic agent used to minimize bleeding in cardiac surgery. Up 50% surgical patients have chronic renal dysfunction (CRD). Optimal dosing of TXA CRD remains poorly investigated. This important as renally eliminated with accumulation CRD. High doses are associated postoperative seizures. study measures plasma concentrations for pharmacokinetic modeling and dose adjustment recommendations.This prospective cohort enrolled 48 stages 1-5 CRD, classified...
Nitrous oxide anesthesia causes increased postoperative plasma homocysteine levels. Acute increases in are associated with impaired endothelial function and procoagulant effects. This nitrous oxide-induced increase may therefore affect the risk of perioperative cardiovascular events. prospective, randomized study was designed to evaluate effect levels on myocardial ischemia patients undergoing carotid endarterectomy. After institutional review board approval written informed consent, 90 ASA...
The purpose of this study was to determine the analgesic efficacy, opioid-sparing effect, and tolerability ketorolac administered as an intravenous (IV) bolus followed by a continuous infusion after total hip or knee arthroplasty. After general anesthesia, patients received either placebo 30 mg IV over 15-30 s 5 mg/h for 24 h. All patient-controlled morphine with no background infusion. Patients were assessed at 2, 4, 6, postoperatively respect analgesia, consumption, side effects, blood...
Several factors may influence the incidences of postoperative nausea and vomiting. In women, one these be timing their surgery in relation to menstrual cycle. The purpose this study was assess effect menstruation efficacy antiemetic droperidol on vomiting.In a prospective randomized double-blind clinical trial, 100 female patients who were scheduled for laparoscopic tubal sterilization stratified basis date last menses into (days 1-8) nonmenstrual 9-28) groups. Patients both groups then...
Preoperative renal insufficiency is an important predictor of the need for postoperative replacement therapy (RRT). Serum creatinine (sCr) has a limited ability to identify patients with preoperative because it varies age, sex, and muscle mass. Calculated clearance (CrCl) alternative measure function that may allow better estimation reserve.Data were prospectively collected consecutive who underwent cardiac surgery requiring cardiopulmonary bypass at tertiary care center. The relation...