Christopher Rajkumar
A5006874125- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Pain Management and Treatment
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Health and Mental Health
- Mobile Health and mHealth Applications
- Peripheral Artery Disease Management
- Cardiac Structural Anomalies and Repair
- Heart Rate Variability and Autonomic Control
Hammersmith Hospital
2003-2025
Imperial College London
2004-2025
Lung Institute
2020-2025
Imperial College Healthcare NHS Trust
2017-2025
National Health Service
2024
Xavier Institute of Management and Entrepreneurship
2023
St. Marianna University School of Medicine
2022
Mayo Clinic in Arizona
2020
St Mary's Hospital
2019
St. Mary's Hospital
2019
Most people who begin statins abandon them, most commonly because of side effects.The purpose this study was to assess daily symptom scores on statin, placebo, and no treatment in participants had abandoned statins.Participants received 12 1-month medication bottles, 4 containing atorvastatin 20 mg, empty. We measured intensity for each using an app (scale 1-100). also the "nocebo" ratio: ratio symptoms induced by taking statin that placebo.A total 60 were randomized 49 completed 12-month...
Percutaneous coronary intervention (PCI) is frequently performed to reduce the symptoms of stable angina. Whether PCI relieves angina more than a placebo procedure in patients who are not receiving antianginal medication remains unknown. We conducted double-blind, randomized, placebo-controlled trial with Patients stopped all medications and underwent 2-week symptom assessment phase before randomization. were then randomly assigned 1:1 ratio undergo or followed for 12 weeks. The primary end...
BackgroundThe coronary sinus reducer (CSR) is proposed to reduce angina in patients with stable artery disease by improving myocardial perfusion. We aimed measure its efficacy, compared placebo, on ischaemia reduction and symptom improvement.MethodsORBITA-COSMIC was a double-blind, randomised, placebo-controlled trial conducted at six UK hospitals. Patients aged 18 years or older angina, disease, ischaemia, no further options for treatment were eligible. All completed quantitative...
In this study, a systematic analysis was conducted of phasic intracoronary pressure and flow velocity in patients with severe aortic stenosis (AS) coronary artery disease, undergoing transcatheter valve replacement (TAVR), to determine how AS affects: 1) flow; 2) hyperemic 3) the most common clinically used indices severity, instantaneous wave-free ratio fractional reserve. A significant proportion have concomitant disease. The effect on pressure, flow, established invasive clinical severity...
Dobutamine stress echocardiography is widely used to test for ischemia in patients with stable coronary artery disease. In this analysis, we studied the ability of prerandomization score predict placebo-controlled efficacy percutaneous intervention (PCI) within ORBITA trial (Objective Randomised Blinded Investigation With Optimal Medical Therapy Angioplasty Stable Angina).One hundred eighty-three underwent dobutamine before randomization. The broadly number segments abnormal at peak stress,...
Cardiac perforations caused by pacemaker or implantable cardioverter-defibrillator (ICD) leads are uncommon but potentially fatal events. The optimal approach to such cases is unclear. aim of this study was identify the imaging modality and management strategy for cardiac perforation.All patients presenting a single institution with perforation >24 h since implant between 2011 2015 were identified retrospectively. Assessment diagnostic performance pre-extraction chest radiography,...
Oxygen-pulse morphology and gas exchange analysis measured during cardiopulmonary exercise testing (CPET) has been associated with myocardial ischaemia. The aim of this was to examine the relationship between CPET parameters, ischaemia anginal symptoms in patients chronic coronary syndrome determine ability these parameters predict placebo-controlled response percutaneous intervention (PCI).
Although state-of-the-art therapy for left main disease (LMD) has been demonstrated to improve overall cardiovascular outcomes, it remains unclear whether differences in strategy and outcomes Japanese non-Japanese patients can be observed a contemporary treatment.
Objective International guidelines recommend the use of dual antiplatelet therapy (DAPT) after transcatheter aortic valve implantation (TAVI). The recommended duration DAPT varies between guidelines. In this two-part study, we (1) performed a structured survey 45 TAVI centres from around world to determine if there is consensus among clinicians regarding TAVI; and then (2) systematic review all suitable studies (randomised controlled trials (RCTs) registries) aspirin monotherapy can be used...
A randomized trial evaluating the coronary sinus reducer for relieving angina by potentially improving myocardial blood flow in patients with no other treatment options, as assessed cardiac MRI and patient symptoms.
Patients with severe aortic stenosis (AS) often have coronary artery disease. Both the valve and disease influence blood flow to myocardium its ability respond stress; leading exertional symptoms. In this study, we aim quantify effect of AS on microcirculation determine if is influenced by any concomitant We then compare stenoses microcirculation.Group 1: 55 patients intermediate treated transcatheter implantation (TAVI) were included. Group 2: 85 no percutaneous intervention Coronary...
Despite guideline-based recommendation of the interchangeable use instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR) to guide revascularization decision-making, iFR/FFR could demonstrate different physiological or clinical outcomes in some specific patient lesion subsets. Therefore, we sought investigate impact difference between iFR FFR-guided decision-making on patients with left main disease (LMD). In this international multicenter registry LMD interrogation, identified...
Abstract There have been no studies comparing clinical outcomes of physiology-guided revascularization in patients with unprotected left main coronary disease (ULMD) between percutaneous intervention (PCI) vs. artery bypass grafting (CABG). The aim this study was to assess the long-term PCI and CABG physiologically significant ULMD. From an international multicenter registry ULMD interrogated instantaneous wave-free ratio (iFR), we analyzed data from 151 (85 66 CABG) who underwent according...
Background: The majority of randomized controlled trials revascularization decision-making excludes left main coronary artery disease (LMD). Therefore, contemporary clinical outcomes patients with stable and LMD proven ischemia remain poorly understood. aim this study was to assess the long-term physiologically significant according treatment strategies versus deferral. Methods: In international multicenter registry interrogated instantaneous wave-free ratio, (instantaneous ratio ≤0.89) were...