A5084649428- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Vasculitis and related conditions
- Renal and Vascular Pathologies
- Retinal Diseases and Treatments
- Hemoglobinopathies and Related Disorders
- Neurological Complications and Syndromes
- Genetic and Kidney Cyst Diseases
- Systemic Lupus Erythematosus Research
- Renal and related cancers
- Retinal Imaging and Analysis
- Sarcoidosis and Beryllium Toxicity Research
- Erythropoietin and Anemia Treatment
- Organ Donation and Transplantation
- Parathyroid Disorders and Treatments
- Electrolyte and hormonal disorders
- Liver Diseases and Immunity
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal cell carcinoma treatment
- Alcohol Consumption and Health Effects
- Blood Pressure and Hypertension Studies
- Neurological and metabolic disorders
University of California, Irvine
2019-2025
VA Long Beach Healthcare System
2019-2024
American Heart Association
2023-2024
University of California, Irvine Medical Center
2020-2024
Amyloidosis Foundation
2022
Boston University
2022
UC Irvine Health
2021
RELX Group (United States)
2019-2020
International Society of Nephrology
2020
University of California, Los Angeles
2012-2020
Novel coronavirus disease 2019 (COVID-19) is a highly infectious, rapidly spreading viral with an alarming case fatality rate up to 5%. The risk factors for severe presentations are concentrated in patients chronic kidney disease, particularly end-stage renal (ESRD) who dialysis dependent. We report the first US of 56-year-old nondiabetic male ESRD secondary IgA nephropathy undergoing thrice-weekly maintenance hemodialysis 3 years, developed COVID-19 infection. He has hypertension controlled...
High mortality in dialysis patients is linked to malnutrition and inflammation. Prognostic nutritional index (PNI), calculated from serum albumin level total lymphocyte count, has been developed as a prognostic marker for cancer patients. We investigated the clinical utility of PNI predicting undergoing hemodialysis. Thus, 101,616 who initiated hemodialysis United States centers between 2007 2011 were included this retrospective cohort study. Using Cox regression model, we assessed...
Carbapenem agents are advanced derivatives of cephalosporins that active against bacteria produce extended spectrum beta lactamases (ESBL). These antibiotics resistant to enzymatic cleavage, and have good central nervous system penetration. Given this fact, it is not surprising these drugs been reported cause neurological side effects like seizures encephalopathy. We report a case patient on hemodialytic support who had notable change in mentation vocal tremor. This was at first attributed...
Vascular endothelial growth factor (VEGF) receptor inhibition is a commonly used tool to prevent vascular proliferation in tumors and retinal diseases. The antiangiogenic effects of these drugs have made them potent adjunct therapies when given systemically for malignancies. They are also useful tools ameliorate diminishing eyesight retinopathy. Hypertension proteinuria been observed systemic VEGF inhibitor therapy, with rarer presentations involving nephrotic-range due glomerulopathies....
Thrombotic microangiopathy encompasses microvascular thrombosis, hemolytic anemia, thrombocytopenia, and end-organ damage. Secondary thrombotic can result from malignancies, autoimmune diseases, or treatments such as tyrosine kinase inhibitors. Dasatinib, a inhibitor used in managing chronic myeloid leukemia, has been linked to microangiopathy. This report describes 66-year-old female with leukemia treated dasatinib who developed renal-limited Progressive renal dysfunction found the context...
<h3>Objective:</h3> We sought to create a classification system for pediatric corpus callosal abnormalities (CCA) based upon midline sagittal brain MRI. used the term CCA patients with structural variants of callosum, excluding interhemispheric cyst variant or pure dysplasia without hypoplasia. Currently, no exists nonsyndromic forms CCA, and attempts such have been hampered by highly variable morphology in sporadic CCA. reasoned that any useful strategy should classify affected family...
Improper correction of hyponatremia can cause severe complications, including osmotic demyelination syndrome (ODS). The Adrogué–Madias equation (AM), the Barsoum–Levine (BL) equation, Electrolyte Free Water Clearance (EFWC) and Nguyen–Kurtz (NK) are four derived equations based on empirically Edelman for predicting sodium at a later time (Na2) from known starting (Na1), fluid/electrolyte composition input output volumes. Our retrospective study included 43 data points 31 mostly hyponatremic...
Vascular Endothelial Growth Factor (VEGF) inhibition can cause worsening hypertension, proteinuria, chronic kidney injury, as well glomerular disease. Thrombotic Microangiopathy (TMA) and other nephrotic disorders have been reported with systemic VEGF blockade. These same agents are given intravitreally for age related macular degeneration (AMD) Diabetic Retinopathy (DR), albeit at lower doses than those indications. Systemic absorption of anti-VEGF when has shown consistently along evidence...
Certain diabetic and hypertensive patients started on intravitreal vascular endothelial growth factor inhibition for retinopathy may experience worsening of hypertension proteinuria. The etiology this is the newly recognized absorption intravitreally injected inhibitors, susceptibility with pre-existing renal disease to exacerbations depends degree systemic absorption. There are eighteen reported cases hypertension, woresening proteinuria, function, thrombotic microangiopathy, glomerular...
Abstract Background The KBindER (K + Binders in Emergency Room and hospitalized patients) clinical trial is the first head-to-head evaluation of oral potassium binders (cation-exchange resins) for acute hyperkalemia therapy. Methods room patients with a blood level ≥ 5.5 mEq/L are randomized to one four study groups: binder drug (sodium polystyrene sulfonate, patiromer, or sodium zirconium cyclosilicate) nonspecific laxative (polyethylene glycol). Exclusion criteria include recent bowel...
This is a report of patient with minimal change disease (MCD) onset after bevacizumab administration. A 72-year-old man inoperable Grade 3 astrocytoma was treated combination temozolomide and the vascular endothelial growth factor monoclonal antibody bevacizumab. After two biweekly treatments, he developed nephrotic syndrome. Despite cessation bevacizumab, his renal function deteriorated biopsy disclosed MCD. Thereafter, started on high-dose oral prednisone immediately improved. Within...
Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death protein 1 (PD-1) antigen and induces response against tumor tissues. It has been successful in inducing remission patients with severe metastatic disease, often refractory to other chemotherapeutic agents. The risk of injury organ systems noted reported cases glomerular disease endocrine disease. In addition, hypophysitis as well dermatological gastroenterological side effects have reported. Renal...