Fabrizio Monaco
A5010431868- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Thyroid Disorders and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac and Coronary Surgery Techniques
- Cardiac Arrhythmias and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Aortic aneurysm repair treatments
- Cardiac pacing and defibrillation studies
- Blood transfusion and management
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Neurotoxicity Research
- Heart Failure Treatment and Management
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2016-2025
San Raffaele University of Rome
2011-2024
IRCCS Ospedale San Raffaele
2015-2024
Sechenov University
2024
Eastern Virginia Medical School
2003-2020
Urology of Virginia
2020
Bambino Gesù Children's Hospital
2019
Monash University
2018
Acute left ventricular dysfunction is a major complication of cardiac surgery and associated with increased mortality. Meta-analyses small trials suggest that levosimendan may result in higher rate survival among patients undergoing surgery.
Describe characteristics, daily care and outcomes of patients with coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS).Case series 73 patients.Large tertiary hospital in Milan.Mechanically ventilated confirmed COVID-19 admitted to the intensive unit (ICU) between 20 February 2 April 2020.Demographic clinical data were collected identify predictors early mortality.Of included study, most male (83.6%), median age was 61 years (interquartile range [IQR], 54-69 years),...
At the end of 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak spread from China all around world, causing thousands deaths. In Italy, hardest hit region was Lombardy, with first reported case on 20 February 2020. San Raffaele Scientific Institute — a large tertiary hospital and research centre in Milan, Italy immediately involved management public health emergency. Since beginning outbreak, elective surgical activity rapidly reduced areas were simultaneously...
Volatile (inhaled) anesthetic agents have cardioprotective effects, which might improve clinical outcomes in patients undergoing coronary-artery bypass grafting (CABG).We conducted a pragmatic, multicenter, single-blind, controlled trial at 36 centers 13 countries. Patients scheduled to undergo elective CABG were randomly assigned an intraoperative regimen that included volatile (desflurane, isoflurane, or sevoflurane) total intravenous anesthesia. The primary outcome was death from any...
BACKGROUND: Prospective, single-center trials have shown that the implementation of Kidney Disease: Improving Global Outcomes (KDIGO) recommendations in high-risk patients significantly reduced development acute kidney injury (AKI) after surgery. We sought to evaluate feasibility implementing a bundle supportive measures based on KDIGO guideline undergoing cardiac surgery multicenter setting preparation for large definitive trial. METHODS: In this multicenter, multinational, randomized...
Consensus recommendations regarding the threshold levels of cardiac troponin elevations for definition perioperative myocardial infarction and clinically important periprocedural injury in patients undergoing surgery range widely (from >10 times to ≥70 upper reference limit assay). Limited evidence is available support these recommendations.
Acute kidney injury (AKI) is a serious and common complication of cardiac surgery, for which reduced perfusion key contributing factor. Intravenous amino acids increase recruit renal functional reserve. However, the efficacy in reducing occurrence AKI after surgery uncertain.
We report the experience in a cohort of consecutive patients receiving extracorporeal membrane oxygenation during catheter ablation unstable ventricular tachycardia (VT) at our center.From 2010 to 2015, was initiated 64 (average age: 63±15 years; left ejection fraction 27±9%; cardiogenic shock 23%, and electrical storm 62% patients) undergoing 74 VT procedures. At least one terminated 81% procedures with baseline inducible VT, noninducibility achieved 69%. Acute heart failure occurred 5...
In patients undergoing cardiac surgery, a reduced preoperative left ventricular ejection fraction (LVEF) is common and associated with worse outcome. Available outcome data for these address specific surgical procedures, mainly coronary artery bypass graft (CABG). Aim of our study was to investigate perioperative surgery on low pre-operative LVEF broad range procedures. Data from ≤40 % at university hospital were reviewed analyzed. A subgroup analysis ≤30 also performed. total 7313 underwent...
Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors outcome of AKI CRRT COVID-19 patients. Methods: Observational a tertiary care hospital Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed 17 (17.7%) received CRRT. Most stage 1 (33 [45.8%]), while 15...
Graves' disease (GD) is caused by persistent, unregulated stimulation of thyrocytes thyroid-stimulating antibodies (TSAbs) that activate the TSH receptor (TSHR). We previously reported first small-molecule antagonist human TSHR and showed it inhibited signaling stimulated sera from four patients with GD.Our objective was to develop a better use determine whether inhibition TSAb activation general phenomenon.We aimed chemically modify ligand inhibits 30 GD sera. measured in two vitro systems:...
Objectives: We aimed to identify all treatments that affect mortality in adult critically ill patients multicenter randomized controlled trials. also evaluated the methodological aspects of these studies, and we surveyed clinicians' opinion usual practice for selected interventions. Data Sources: MEDLINE/PubMed, Scopus, Embase were searched. Further articles suggested inclusion from experts cross-check references. Study Selection: fulfilled following criteria: publication a peer-reviewed...