A5035639918- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Acute Kidney Injury Research
- Hemodynamic Monitoring and Therapy
- Anesthesia and Neurotoxicity Research
- Pain Management and Opioid Use
- Pediatric Pain Management Techniques
- Spine and Intervertebral Disc Pathology
- Neonatal Respiratory Health Research
- Treatment of Major Depression
- Liver Disease and Transplantation
- Musculoskeletal pain and rehabilitation
- Nausea and vomiting management
- Cardiac Arrest and Resuscitation
- Enhanced Recovery After Surgery
- Infant Health and Development
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 and Mental Health
- Infant Development and Preterm Care
- Pharmacological Effects and Toxicity Studies
- Organ Transplantation Techniques and Outcomes
GITAM University
2025
St. Vincent's University Hospital
2019-2023
King's College Hospital
2018-2021
King's College Hospital NHS Foundation Trust
2021
King's College London
2020
Barro Colorado Island
2019
Our Lady's Hospital
2017
Children's Health Ireland at Crumlin
2017
BACKGROUND: Prospective, single-center trials have shown that the implementation of Kidney Disease: Improving Global Outcomes (KDIGO) recommendations in high-risk patients significantly reduced development acute kidney injury (AKI) after surgery. We sought to evaluate feasibility implementing a bundle supportive measures based on KDIGO guideline undergoing cardiac surgery multicenter setting preparation for large definitive trial. METHODS: In this multicenter, multinational, randomized...
The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend a bundle of different measures for patients at increased risk acute kidney injury (AKI). Prospective, single-center, randomized controlled trials (RCTs) have shown that management in accordance with the KDIGO recommendations was associated significant reduction incidence postoperative AKI high-risk patients. However, compliance routine clinical practice is unknown.This observational prevalence study performed...
Hemorrhage and venous thromboembolism (VTE) are recognized complications of chronic liver disease (CLD), but their prevalence risk factors in critically ill patients uncertain.We studied a retrospective cohort with CLD nonelectively admitted to specialist intensive care unit (ICU) determining the timing major bleeding VTE (early, present on admission/diagnosed within 48 hours; later, diagnosed >48 hours post-ICU admission). Associations baseline clinical laboratory characteristics,...
Acute kidney injury (AKI) is a frequent complication after cardiac surgery with adverse short-term and long-term outcomes. Although prevention of AKI (PrevAKI) strongly recommended, the optimal strategy uncertain. The Kidney Disease: Improving Global Outcomes (KDIGO) guideline recommended bundle supportive measures in high-risk patients. In single-centre trial, we recently demonstrated that strict implementation KDIGO significantly reduced occurrence surgery. this feasibility study, aim to...
Introduction Chronic pain is defined as lasting longer than 3 months. This often causes persistent emotional distress and functional disability that refractory to conventional treatments. Emerging evidence suggests oral Ketamine therapy may have a specific role in managing treatment-resistant chronic pain. study aimed assess the effectiveness of ketamine within tertiary management clinic. Methods was clinic-based retrospective descriptive 79 patients with broad range diagnoses treated over...
Hepatopancreaticobiliary (HPB) surgery is major upper abdominal with considerable risk of pulmonary complications related to postoperative pain. While epidural analgesia remains an effective analgesic technique for surgery, HPB poses challenges its use due coagulopathy. Erector spinae plane (ESP) blocks are a promising alternative epidurals. Injection local anesthetic deep the erector muscle and placement catheter prolonged effect provide both somatic visceral thoracic surgery. We describe...
Summary Intrathecal morphine is an analgesic option for major hepatopancreaticobiliary procedures but associated with a risk of respiratory depression. We hypothesised that postoperative low‐dose naloxone infusion would reduce the incidence depression without increase in pain scores. Patients scheduled open surgery and who were receiving 10 μg.kg −1 intrathecal eligible inclusion. allocated randomly to receive 5 .h (naloxone group) or saline at identical rate (control until morning after...
LILBURN, J. K.; DUNDEE, W.; NAIR, S. G.; FEE, P. H.; JOHNSTON, H. M. L. Author Information
Lorazepam has been studied as preanaesthetic medication given by mouth, i.m. and i.v. Sedation side-effects the incidence of anterograde amnesia in patients having a standard operation under methohexitone-nitrous oxide-oxygen anaesthesia were assessed. In preliminary study three (2-, 4- 8-mg) six oral (1-, 2-, 2.5-, 4-, 5- doses, optimum dose was found to be 4 mg for with an average weight 60 kg. This detail when all routes compared commercially available 2.5-and 5-mg tablets. Even i.v.,...