A5040185267- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Economic and Financial Impacts of Cancer
- Venous Thromboembolism Diagnosis and Management
- Global Cancer Incidence and Screening
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Organ Transplantation Techniques and Outcomes
- Biomedical Text Mining and Ontologies
- Blood Coagulation and Thrombosis Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Hepatotoxicity and Protection
- Clinical practice guidelines implementation
Royal Adelaide Hospital
2016-2024
Flinders Medical Centre
2022
King's College Hospital NHS Foundation Trust
2021
King's College Hospital
2017-2020
Background and AimsPatients with cirrhosis have a rebalanced hemostasis, often normal or elevated thrombin‐generating (TG) capacity in plasma. Whole blood (WB) TG allows faster determination and, importantly, includes the influence of all circulating cells. We aimed to study profile patients WB platelet poor plasma.MethodsThrombin‐generating plasma were assessed near‐patient WB‐TG assay calibrated automated thrombinography assay, respectively. assays tested presence absence thrombomodulin....
Hemorrhage and venous thromboembolism (VTE) are recognized complications of chronic liver disease (CLD), but their prevalence risk factors in critically ill patients uncertain.We studied a retrospective cohort with CLD nonelectively admitted to specialist intensive care unit (ICU) determining the timing major bleeding VTE (early, present on admission/diagnosed within 48 hours; later, diagnosed >48 hours post-ICU admission). Associations baseline clinical laboratory characteristics,...
In vitro efficacy of pro- and antihemostatic drugs is profoundly different in patients with compensated cirrhosis those who have are critically ill.Here we assessed the anticoagulant plasma undergoing hepato-pancreato-biliary (HPB) surgery, which associated unique hemostatic changes.We performed analyses on blood samples 60 HPB surgery liver transplantation: 20 orthotopic transplantations, partial hepatectomies, pylorus-preserving pancreaticoduodenectomies. We thrombin generation experiments...
Background Australia’s bowel cancer prevention guidelines, following a recent revision, are among the most complex in world. Detailed decision tables outline screening or surveillance recommendations for 230 case scenarios alongside cessation older patients. While these guidelines can help better allocate limited colonoscopy resources, their increasing complexity may limit adoption and potential benefits. Therefore, tools to support clinicians navigating could be essential national efforts....
Abstract Background In keeping with recent trends, patients hepatocellular cancer have had their care managed by a dedicated Nurse Coordinator at our tertiary Australian hospital since 2010. To date, there are few data to justify the cost‐effectiveness of this approach. Aims quantify potential cost saved through employment in management carcinoma single tertiary‐level hospital. Methods A retrospective audit between 2010 and 2015 was conducted. Consensus reports from previous meetings were...
The latest update to the Australian adenoma surveillance guideline in 2018 introduced a novel risk stratification system with updated recommendations. resource implications of adopting this new are unclear.
Algorithms for the surveillance of colorectal adenomas have recently undergone revision in Australia and abroad. Despite a shared evidence base, significant differences are observed optimal intervals remain controversial. We sought to explore their relation current evidence, practical aspects how we may improve our own approach adenoma Australia.
<sec> <title>BACKGROUND</title> Australia’s bowel cancer prevention guidelines, following a recent revision, are among the most complex in world. Detailed decision tables outline screening or surveillance recommendations for 230 case scenarios alongside cessation older patients. While these guidelines can help better allocate limited colonoscopy resources, their increasing complexity may limit adoption and potential benefits. Therefore, tools to support clinicians navigating could be...
Ensuring colonoscopy procedure quality is vital to the success of screening and surveillance programmes for bowel cancer in Australia. However, data on performance metrics, through adequate adenoma detection, preparation, completion rates, Australian public sector limited. Understanding these can inform improvement further strengthen our capacity prevention early detection colorectal cancer.To determine teaching hospitals their association with proceduralist specialty, trainee involvement,...