A5088633757- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Pediatric Pain Management Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Congenital Heart Disease Studies
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Nausea and vomiting management
- Birth, Development, and Health
- Heart Rate Variability and Autonomic Control
- Aortic Disease and Treatment Approaches
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Pharmaceutical studies and practices
- Cardiovascular Conditions and Treatments
- Pain Management and Opioid Use
- Antibiotics Pharmacokinetics and Efficacy
- Infant Development and Preterm Care
- Tracheal and airway disorders
- Blood Pressure and Hypertension Studies
- Coronary Artery Anomalies
- Neuroendocrine regulation and behavior
University of Bonn
2023
UCLouvain
2023
Icahn School of Medicine at Mount Sinai
2022
University of Bristol
1991-2017
Bristol Royal Hospital for Children
2007-2017
Our Lady's Hospital
2015-2016
Montreal Heart Institute
2015
Virginia Department of Environmental Quality
2015
University Hospitals Bristol NHS Foundation Trust
2015
At Bristol
2014
Summary Background: The aim of this study was to investigate the current practice sedation, analgesia, and neuromuscular blockade in critically ill children on pediatric intensive care units (PICUs) UK identify areas that merit further study. Methods: Data were gathered a prospective observational 338 20 PICUs. Results: There is considerable variation clinical practice. A total 24 different sedative analgesic agents used during most commonly midazolam morphine. Four blockers (NMBs) used,...
We prospectively studied the post-operative recovery profile of 28 ex-premature infants undergoing inguinal herniotomy. All had a post-conceptual age less than 46 weeks at time surgery and were randomized to receive either sevoflurane (group 1, 14 patients) or spinal anaesthesia 2, patients). patients received supplemental caudal analgesia before skin incision. Cardiorespiratory function was continuously recorded in all after surgery. A blinded observer analysed each paired recording for...
Background Propofol is a commonly used anesthetic induction agent in pediatric anesthesia that, until recently, was with caution as an intravenous infusion for sedation intensive care. Few data have described propofol kinetics critically ill children. Methods Twenty-one ventilated children aged 1 week to 12 yr were sedated 4-6 mg. kg(-1).h(-1) of 2% up 28 h, combined constant morphine infusion. Whole blood concentration measured at steady state and 24 h after using high-performance liquid...
Twenty‐six infants due to undergo major abdominal or thoracic surgery under general anaesthesia were randomized receive additional analgesia with group A) spinal/epidural analgesia; B) epidural C) opioid fentanyl. We wished determine if spinal followed by might result in more complete control of cardiovascular stress responses than the other two treatment groups. Heart rate and blood pressure recorded at five min intervals throughout surgery. Blood samples taken for measurement...
Children in paediatric intensive care units (PICUs) require analgesia and sedation but both undersedation oversedation can be harmful.Evaluation of intravenous (i.v.) clonidine as an alternative to i.v. midazolam.Multicentre, double-blind, randomised equivalence trial.Ten UK PICUs.Children (30 days 15 years inclusive) weighing ≤ 50 kg, expected ventilation on PICU for > 12 hours.Clonidine (3 µg/kg loading then 0-3 µg/kg/hour) versus midazolam (200 0-200 µg/kg/hour). Maintenance infusion...
Objective/Background Historically, the sole option for patients with a dysfunctional native right ventricular outflow tract (RVOT) requiring re‐establishment of pulmonary competence has been surgical PVR. We sought to compare early outcomes hybrid valve replacement (PVR) combining plication main artery followed by transcatheter PVR, contemporary cohort PVR patients. Methods Retrospective chart analysis all dilated RVOT eligible over 36 months was performed. The cohorts included previous...
Coarctation of the aorta (CoA) is associated with hypertension and abnormalities blood pressure control, which persist after late repair. Assumptions that neonatal repair would prevent development have not been supported by recent data. We hypothesized early pathological adjustment autonomic cardiovascular function may already be established in neonate coarctation.We studied 8 otherwise well neonates simple CoA compared measures spontaneous baroreflex sensitivity, heart rate variability,...