A5032052914- Blood transfusion and management
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Organ Transplantation Techniques and Outcomes
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Pediatric Pain Management Techniques
- Pancreatic and Hepatic Oncology Research
- Testicular diseases and treatments
- Nausea and vomiting management
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Artificial Intelligence in Healthcare and Education
- Cardiac and Coronary Surgery Techniques
- Intensive Care Unit Cognitive Disorders
- Pain Management and Opioid Use
- Anesthesia and Neurotoxicity Research
- Transplantation: Methods and Outcomes
- Ethics in Clinical Research
Tallaght University Hospital
2019
St. Vincent's University Hospital
2017
Edinburgh Royal Infirmary
2010-2014
Summary Intrathecal morphine is an analgesic option for major hepatopancreaticobiliary procedures but associated with a risk of respiratory depression. We hypothesised that postoperative low‐dose naloxone infusion would reduce the incidence depression without increase in pain scores. Patients scheduled open surgery and who were receiving 10 μg.kg −1 intrathecal eligible inclusion. allocated randomly to receive 5 .h (naloxone group) or saline at identical rate (control until morning after...
Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for respiratory depression at doses required currently limits its clinical use. The use low-dose, prophylactic naloxone infusion intrathecally may significantly reduce depression. NAPRESSIM trial aims to answer this question. ‘The prevent with morphine’ an investigator-led, single-centre, randomised, double-blind,...