A5101410849- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Cancer Immunotherapy and Biomarkers
- Sexual function and dysfunction studies
- Acute Kidney Injury Research
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Urological Disorders and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Airway Management and Intubation Techniques
- Renal cell carcinoma treatment
- Respiratory Support and Mechanisms
- Pancreatic and Hepatic Oncology Research
- Cardiac Arrest and Resuscitation
- Enhanced Recovery After Surgery
- Bladder and Urothelial Cancer Treatments
- Anesthesia and Neurotoxicity Research
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- Neurosurgical Procedures and Complications
- Cardiac and Coronary Surgery Techniques
- Meta-analysis and systematic reviews
Emek Medical Center
2020-2024
Mayo Clinic
2021
WinnMed
2021
Ospedale G.B. Morgagni - L.Pierantoni
2021
Ben-Gurion University of the Negev
2021
Soroka Medical Center
2021
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2014-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2020
Vita-Salute San Raffaele University
2014-2020
University of Florence
2015-2018
At the end of 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak spread from China all around world, causing thousands deaths. In Italy, hardest hit region was Lombardy, with first reported case on 20 February 2020. San Raffaele Scientific Institute — a large tertiary hospital and research centre in Milan, Italy immediately involved management public health emergency. Since beginning outbreak, elective surgical activity rapidly reduced areas were simultaneously...
No effective pharmaceutical agents have yet been identified to treat acute kidney injury after cardiac surgery.To determine whether fenoldopam reduces the need for renal replacement therapy in critically ill surgery patients with injury.Multicenter, randomized, double-blind, placebo-controlled, parallel-group study from March 2008 April 2013 19 cardiovascular intensive care units Italy. We randomly assigned 667 admitted early (≥50% increase of serum creatinine level baseline or oliguria ≥6...
The introduction of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment standards and significantly enhanced patient prognoses. However, the utilization these groundbreaking therapies led to observation reporting various types adverse events, commonly known as immune-related events (irAEs). In following article, we present four patients who encountered uncommon toxicities induced by ICIs. first was a 59-year-old female diagnosed with stage 4 lung adenocarcinoma. She...
Patient prognoses have been significantly enhanced by immune checkpoint inhibitors (ICIs), altering the standard of care in cancer treatment. These novel antibodies become a mainstay for metastatic non-small-cell lung (mNSCLC) patients. Several types adverse events related to ICIs identified and documented as result launch these innovative medicines. We present here 74-year-old female patient with stage IV adenocarcinoma, treated nivolumab plus ipilimumab, who developed perimyocarditis two...
Radiotherapy is one of the treatment options for prostate cancer (PCa) but up to 25 % men report about severe nocturia (nocturnal voiding). The combination hyaluronic acid (HA) and chondroitin sulfate (CS) resembles glycosaminoglycan (GAG) replenishment therapy. aim our study was evaluate impact HA CS on nocturia, in with after PCa radiotherapy. Twenty-three consecutive patients symptomatic cystitis external radiotherapy were enrolled. Patients underwent bladder instillation therapy weekly...
<b><i>Objective:</i></b> To evaluate health-related quality of life (HR-QoL) outcomes in elderly patients with different type urinary diversion (UD), ileal conduit (IC) and orthotopic neobladder (IONB), after radical cystectomy (RC) for bladder cancer, by using validated self-reported cancer-specific instruments. <b><i>Patients Methods:</i></b> We retrospectively reviewed 77 who received an IC or IONB RC. HR-QoL was assessed specific disease...
In the present case report, we aimed to describe 2 cases of myocarditis occurring as serious adverse effects immune checkpoint inhibitors (ICIs) administered treatment for metastatic melanoma. We female patients: an 81-year-old treated with pembrolizumab and a 55-year-old combination nivolumab ipilimumab. Both patients underwent resection metastases; while under treatment, both developed myocarditis, most probably toxicity from plus Ipilimumab, respectively. While they achieved complete...
Immune checkpoint inhibitors (ICIs) have transformed the therapeutic approach to diverse malignancies, leading substantial enhancements in patient prognosis. However, along with their benefits, ICIs also increase incidence of immune-related adverse events (irAEs). In present paper, we highlight four cases carpal tunnel syndrome (CTS) as an uncommon manifestation toxicity induced by ICIs. Although diagnosed different patients were undergoing ICI therapy when they developed CTS-consistent side...
Context: Myocardial injury during cardiac surgery on cardiopulmonary bypass (CPB) is a major determinant of morbidity and mortality.Preclinical clinical evidence dose-and time-related cardioprotective effects volatile anesthetic drugs exist their use the whole duration could improve perioperative protection.Even if administering agents CPB are relatively easy, technical problems, such as waste gas scavenging, may prevent safe manageable administration halogenated vapors CPB.Aims: The aim...
In the following report, we describe a case of alkaline phosphatase (ALP) elevation occurring during treatment with alectinib (Alecensa™), which was administered for anaplastic lymphoma kinase (ALK) mutated metastatic non-small cell lung cancer (mNSCLC). A 51 year-old female widespread disease exhibited rapid and significant response within very short period to therapy, accompanied by increase ALP more than six times upper limit normal (grade 3) ALP, decreasing limits 3 weeks after...
Anticoagulation with unfractionated heparin in cardiac surgery patients has several limitations, and above all the risk of heparin-induced thrombocytopenia. Bivalirudin is a direct thrombin inhibitor, use which expanded recent years. The aim study was to analyze two strategies for introducing bivalirudin this setting (as secondary drug switching from or as primary anticoagulant) evaluate clinical outcomes.
Background: Freezing rain, also known as gelicidium, glaze, or ice storm, is an unpredictable and rare meteorological event with impact on millions of citizens which can affect the healthcare system large areas. It occurs if rain hits ground when surface temperatures are below 0 ◦C. Objective: To report what occurred January 13th 2017 in Lombardy, a northern Italy region Milan capital, freezing caused overload emergency system. Methods: We obtained data vehicles calls missions from reports...