A5047818316- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Family and Patient Care in Intensive Care Units
- Ultrasound in Clinical Applications
- Long-Term Effects of COVID-19
- Congenital Diaphragmatic Hernia Studies
- Bone and Dental Protein Studies
- Hemodynamic Monitoring and Therapy
- Neonatal Respiratory Health Research
- Acute Kidney Injury Research
- Extracellular vesicles in disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nosocomial Infections in ICU
- Anesthesia and Sedative Agents
- Thermal Regulation in Medicine
- Mechanical Circulatory Support Devices
- Pneumonia and Respiratory Infections
- Neuroscience of respiration and sleep
- Methemoglobinemia and Tumor Lysis Syndrome
- Dermatological and COVID-19 studies
- Non-Invasive Vital Sign Monitoring
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2016-2025
Azienda Ospedaliero Universitaria Maggiore della Carita
2015-2025
Ospedale Maggiore
2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023
Ospedale SS. Annunziata
2023
University of Perugia
2023
Intensive Care Society
2021
Policlinico San Matteo Fondazione
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2020
University of Parma
2020
Oxygen is commonly administered after extubation. Although several devices are available, data about their clinical efficacy scarce.To compare the effects of Venturi mask and nasal high-flow (NHF) therapy on PaO2/FiO2SET ratio Secondary endpoints were to assess patient discomfort, adverse events, outcomes.Randomized, controlled, open-label trial 105 patients with a PaO2/FiO2 less than or equal 300 immediately before The (n = 52) NHF 53) applied for 48 hours postextubation.PaO2/FiO2SET,...
The value of visual inspection ventilator waveforms in detecting patient-ventilator asynchronies the intensive care unit has never been systematically evaluated. This study aims to assess physicians' ability identify through waveforms.Prospective observational study.Intensive a University Hospital.Twenty-four patients receiving mechanical ventilation for acute respiratory failure.Forty-three 5-min reports displaying flow-time and airway pressure-time tracings were evaluated by 10 expert...
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to nearly every continent, registering over 1,250,000 deaths worldwide. effects of SARS-CoV-2 on host targets remains largely limited, hampering our understanding Coronavirus Disease 2019 (COVID-19) pathogenesis and the development therapeutic strategies. present study used a comprehensive untargeted metabolomic lipidomic approach capture response infection. We found that several circulating lipids acted as...
Knowledge of the host response to novel coronavirus SARS-CoV-2 remains limited, hindering understanding COVID-19 pathogenesis and development therapeutic strategies. During course a viral infection, cells release exosomes other extracellular vesicles carrying components that can modulate immune response. The present study used shotgun proteomic approach map circulating exosomes’ infection. We investigated how infection modulates exosome content, involvement in disease progression, potential...
Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, novel needed better predict patient outcome. The aim of this study was evaluate the diagnostic performance circulating platelets (PLT)-derived extracellular vesicles (EVs) as for infection, by setting a rapid reliable test on unmanipulated blood samples. PLT-EVs were quantified flow...
Evaluating the physiologic effects of varying depths propofol sedation on patient-ventilator interaction and synchrony during pressure support ventilation neurally adjusted ventilatory assist.Prospective crossover randomized controlled trial.University hospital ICU.Fourteen intubated patients mechanically ventilated for acute respiratory failure.Six 25-minute trials randomly performed applying both assist wakefulness with two doses propofol, administered by Target Control Infusion,...
Early identification of noninvasive ventilation (NIV) outcome predictors in patients with COPD who are experiencing acute hypercapnic respiratory failure consequent to exacerbation or pneumonia is a critical issue. The primary aim this study was investigate the feasibility performing diaphragmatic ultrasound for excursion, thickness, and thickening fraction highly dyspneic subjects admitted emergency department pneumonia, before starting NIV (T0) after first (T1) second hour (T2) treatment....
We aimed to characterise a large population of coronavirus disease 2019 (COVID-19) patients with moderate-to-severe hypoxaemic acute respiratory failure (ARF) receiving continuous positive airway pressure (CPAP) outside the intensive care unit (ICU), and ascertain whether duration CPAP application increased risk mortality for requiring intubation.In this retrospective, multicentre cohort study, we included adult COVID-19 patients, treated ICU ARF from 1 March 15 April, 2020. collected...
As delayed intubation may worsen the outcome of coronavirus disease 2019 (COVID-19) patients treated with continuous positive airway pressure (CPAP), we sought to determine COVID-specific early predictors CPAP failure.In this observational retrospective multicentre study, included all COVID-19 out-of-ICU CPAP, candidates for in case failure. From these patients, collected demographic and clinical data.A total 397 were respiratory failure, therapeutic goal providing Univariable analysis...
Rationale: When compared with VenturiMask after extubation, high-flow nasal oxygen provides physiological advantages. Objectives: To establish whether prevents endotracheal reintubation in hypoxemic patients VenturiMask. Methods: In this multicenter randomized trial, 494 exhibiting PaO2:FiO2 ratio ⩽ 300 mm Hg extubation were randomly assigned to receive or oxygen, the possibility apply rescue noninvasive ventilation before reintubation. High-flow use group was not permitted. Measurements and...
As lactoferrin is a nutritional supplement with proven antiviral and immunomodulatory abilities, it may be used to improve the clinical course of COVID-19. The efficacy safety bovine were evaluated in LAC randomized double-blind placebo-controlled trial. A total 218 hospitalized adult patients moderate-to-severe COVID-19 receive 800 mg/die oral (n = 113) or placebo 105), both given combination standard therapy. No differences vs. observed primary outcomes: proportion death intensive care...
Pregnancy at advanced maternal age (AMA) is a condition of potential risk for the development maternal-fetal complications with possible repercussions even in long-term. Here, we analyzed changes plasma redox balance and effects on human umbilical cord mesenchymal cells (hUMSCs) AMA pregnant women (patients) various timing pregnancy. One hundred patients twenty younger than 40 years (controls) were recruited, evaluated timings during pregnancy until after delivery. Plasma samples used to...
Pregnancy at advanced maternal age (AMA) is a condition of potential risk for the development maternal–fetal complications with possible repercussions even in long term. Here, we analyzed changes plasma redox balance and effects on human umbilical cord mesenchymal cells (hUMSCs) AMA pregnant women (patients) various timings pregnancy. One hundred patients twenty younger than 40 years (controls) were recruited evaluated during pregnancy until after delivery. Plasma samples used to measure...
Predicting whether an obese critically ill patient can be successfully extubated may specially challenging. Several weaning tests have been described but no physiological study has evaluated the test that would best reflect post-extubation inspiratory effort. This was a randomized crossover in medical and surgical single-center Intensive Care Unit, patients with body mass index (BMI) >35 kg/m2 who were mechanically ventilated for more than 24 h underwent test. After randomization, 17...
The choice of the interface for noninvasive ventilation (NIV) is a key factor in NIV success. We hypothesised that new helmet specifically design to improve performance hypercapnic patients would be clinically equivalent standard oronasal mask. In multicentre, short-term, physiological, randomised trial chronic obstructive pulmonary disease facing an acute respiratory failure episode, we compared changes arterial blood gases (ABGs) and tolerance score obtained using or mask, and, as...
Compared to pneumatically controlled pressure support (PSP), neurally adjusted ventilatory assist (NAVA) was proved improve patient-ventilator interactions, while not affecting comfort, diaphragm electrical activity (EAdi), and arterial blood gases (ABGs). This study compares (PSN) with PSP NAVA, delivered through two different helmets, in hypoxemic patients receiving noninvasive ventilation for prevention of extubation failure.Fifteen underwent three (PSP, PSN) 30-min trials random order...
Abstract In this viewpoint, we summarize the relevance of thromboinflammation in COVID-19 and discuss potential mechanisms endothelial injury as a key point for development lung distant organ dysfunction, with focus on direct viral infection cytokine-mediated injury. Entanglement between inflammation coagulation resistance to heparin provide rationale consider other therapeutic approaches order preserve function limit microthrombosis, especially severe forms. These strategies include...