Martina Costanzo
A5000277813- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Vitamin D Research Studies
- Liver Disease Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Liver Diseases and Immunity
- Infant Nutrition and Health
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Gallbladder and Bile Duct Disorders
- Bacterial Infections and Vaccines
- Cancer, Stress, Anesthesia, and Immune Response
- Viral gastroenteritis research and epidemiology
- Bone and Dental Protein Studies
- Intensive Care Unit Cognitive Disorders
- Pancreatitis Pathology and Treatment
- Thermal Regulation in Medicine
- Chemical Synthesis and Analysis
- SARS-CoV-2 detection and testing
- Abdominal Trauma and Injuries
- Ovarian cancer diagnosis and treatment
- Vitamin C and Antioxidants Research
- Child and Adolescent Health
- Respiratory Support and Mechanisms
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2019-2023
Azienda Ospedaliero Universitaria Maggiore della Carita
2021-2023
Ospedale Amedeo di Savoia
2022-2023
University of Turin
2022-2023
<h3>Importance</h3> Although plenty of data exist regarding clinical manifestations, course, case fatality rate, and risk factors associated with mortality in severe coronavirus disease 2019 (COVID-19), long-term respiratory functional sequelae survivors COVID-19 are unknown. <h3>Objective</h3> To evaluate the prevalence lung function anomalies, exercise impairment, psychological among patients hospitalized for COVID-19, 4 months after discharge. <h3>Design, Setting, Participants</h3> This...
As lactoferrin is a nutritional supplement with proven antiviral and immunomodulatory abilities, it may be used to improve the clinical course of COVID-19. The efficacy safety bovine were evaluated in LAC randomized double-blind placebo-controlled trial. A total 218 hospitalized adult patients moderate-to-severe COVID-19 receive 800 mg/die oral (n = 113) or placebo 105), both given combination standard therapy. No differences vs. observed primary outcomes: proportion death intensive care...
Background. SARS-CoV-2 is responsible for COVID-19, a clinically heterogeneous disease, ranging from being completely asymptomatic to life-threating manifestations. An unmet clinical need the identification at disease onset or during its course of reliable biomarkers allowing patients’ stratification according severity. In this observational prospective cohort study, immunologic and laboratory signatures were analyzed identify independent predictors unfavorable (either death intensive care...
COVID-19 is characterized by an uncontrolled inflammatory response with high pro-inflammatory cytokine production through the activation of intracellular pathways, such as mitogen-activated protein kinase (MAPK). Viruses are able to exploit MAPK pathway their advantage; this relevance severe poorly described. The aim study was quantify biomarkers involved in and clarify its possible role affecting some COVID-19-related clinical features.H-RAS, C-RAF, MAPK1, MAPK2, ERK were quantified ELISA,...
Vaccines are the most effective means to prevent potentially deadly effects of SARS-CoV-2 infection, but not all vaccinated individuals gain same degree protection. Patients undergoing chronic immunosuppressive therapy due autoimmune diseases or liver transplants, for example, may show impaired anti-SARS-CoV-2 antibody response after vaccination. We performed a prospective observational study with parallel arms, aiming (a) evaluate seroconversion mRNA vaccine administration in different...
More than three years have passed since the first case, and COVID-19 is still a health concern, with several open issues such as lack of reliable predictors patient’s outcome. Osteopontin (OPN) involved in inflammatory response to infection thrombosis driven by chronic inflammation, thus being potential biomarker for COVID-19. The aim study was evaluate OPN predicting negative (death or need ICU admission) positive (discharge and/or clinical resolution within 14 days hospitalization) We...
Reliable biomarkers allowing early patients’ stratification for the risk of adverse outcomes in COVID-19 are lacking. Gas6, together with its tyrosine kinase receptors named TAM, is involved regulation immune homeostasis, fibrosis, and thrombosis. Our aim was to evaluate whether sAxl, sMerTK could represent predictors disease evolution either towards a negative (death or need ICU admission) positive (discharge and/or clinical resolution within first 14 days hospitalization) outcome. To this...
SARS-CoV-2 is a single-stranded RNA virus, known to be the causative agent of COVID-19. As resulting disease shows very heterogeneous range clinical manifestations, identification early biomarkers allowing patients stratification according expected severity still an unmet need.In this observational prospective cohort study, 137 consecutive patients, testing positive for infection by nasopharyngeal swab RT-PCR or antigenic test, were enrolled evaluate their plasma viral load at time...
SARS-CoV-2 is the etiological agent of COVID-19, an extremely heterogenous disease that can cause severe respiratory failure and critical illness. To date, reliable biomarkers allowing for early patient stratification according to severity are still lacking. Calcitonin gene-related peptide (CGRP) a vasoactive neuropeptide involved in lung pathophysiology immune modulation poorly investigated COVID-19 context. In this observational, prospective cohort study, we correlation between CGRP...
Vitamin D deficiency has been associated with the severity of COVID-19. The role vitamin in pregnant women COVID-19 poorly investigated to date. aim this study was evaluate influence affecting some clinical features pregnancy between SARS-CoV-2 positive and negative patients. pathway related polymorphisms 25-hydroxyvitamin levels were quantified followed from first third trimester pregnancy. considered values ≤ 30 ng/mL. In total, 160 enrolled: 23 resulted for at least one test (molecular...
An uncontrolled inflammatory response during SARS-CoV-2 infection has been highlighted in several studies. This seems to be due pro-inflammatory cytokines whose production could regulated by vitamin D, ROS or mitogen-activated protein kinase (MAPK). Several genetic studies are present the literature concerning influences on COVID-19 characteristics, but there few data oxidative stress, MAPK and inflammation-related factors, considering gender age. Therefore, aim of this study was evaluate...
Some anomalies in the breeding cycle of a pack wolf-dog hybrids semi-anthropized area central-western part Calabria are described.The data were collected between October 2019 and March 2021 by direct observations video-camera trapping.In addition to recording anomalous morphological phenotypic traits present varying degrees some individuals pack, we documented for two consecutive years subordinate female that was about three months early compared with normal wolf cycle.Moreover, spring 2020,...
Serous effusions complicating the course of lymphomas occur commonly in pleural space but seldom peritoneum, where they most often present as chylous ascites with diagnostic cytology. Almost invariably, these rare cases, serum to albumin gradient is low. We describe a 28-year-old woman anasarca, and 1.1 g/dl, consistent portal hypertension. No tumour cells were detected ascitic fluid. However, CT scan chest abdomen disclosed liver spleen enlargement multiple enlarged retroperitoneal lymph...