A5069467017- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Parkinson's Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Balance, Gait, and Falls Prevention
- Hereditary Neurological Disorders
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Diabetic Foot Ulcer Assessment and Management
- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone health and osteoporosis research
- Cancer Treatment and Pharmacology
- Neurological disorders and treatments
- Acute Ischemic Stroke Management
- Peripheral Nerve Disorders
- Musculoskeletal pain and rehabilitation
- Facial Rejuvenation and Surgery Techniques
- Osteoarthritis Treatment and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Medical and Biological Ozone Research
- Cardiovascular Syncope and Autonomic Disorders
- Spine and Intervertebral Disc Pathology
- Bone health and treatments
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2016-2025
Humanitas University
2024-2025
IRCCS Humanitas Research Hospital
2024-2025
Ospedale Maggiore
2021-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2021-2024
Magna Graecia University
2023
Azienda Ospedaliero Universitaria Maggiore della Carita
2013-2023
Department of Medical Sciences
2019-2022
University of Milan
2008
<h3>Importance</h3> Although plenty of data exist regarding clinical manifestations, course, case fatality rate, and risk factors associated with mortality in severe coronavirus disease 2019 (COVID-19), long-term respiratory functional sequelae survivors COVID-19 are unknown. <h3>Objective</h3> To evaluate the prevalence lung function anomalies, exercise impairment, psychological among patients hospitalized for COVID-19, 4 months after discharge. <h3>Design, Setting, Participants</h3> This...
Abstract Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution Covid-19, one year discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent follow-up 4 post-Covid-19. 200 consented participate 12-months assessment, including: pulmonary function tests with diffusing lung capacity carbon monoxide (DLCO);...
Abstract Clinical features and natural history of coronavirus disease 2019 (COVID-19) differ widely among different countries during phases the pandemia. Here, we aimed to evaluate case fatality rate (CFR) identify predictors mortality in a cohort COVID-19 patients admitted three hospitals Northern Italy between March 1 April 28, 2020. All these had confirmed diagnosis SARS-CoV-2 infection by molecular methods. During study period 504/1697 died; thus, overall CFR was 29.7%. We looked for...
<h3>Objective:</h3> To evaluate safety (primary objective) and efficacy of increasing doses (400 U up to 800 U) incobotulinumtoxinA (Xeomin, Merz Pharmaceuticals GmbH) for patients with limb spasticity. <h3>Methods:</h3> In this prospective, single-arm, dose-titration study (NCT01603459), (18–80 years) spasticity due cerebral causes, who were clinically deemed require total incobotulinumtoxinA, received 3 consecutive injection cycles (ICs) 400 U, 600 600–800 respectively, each followed by...
BACKGROUND: COVID-19 has been mainly investigated concerning the acute and subacute phase implications management. Meanwhile, few studies focused on midterm sequelae, which still remain largely unknown.AIM: To assess physical performance of survivors at 3 to 6 months from Hospital discharge.DESIGN: A cross-sectional study mid-term functional outcomes evaluation in survivors.SETTING: Outpatients who had previously hospitalized due March May 2020 University Novara, Italy.POPULATION: We...
Botulinum toxin type-A (BoNT-A) has emerged as a key therapeutic agent for the management of spasticity. This paper presents comprehensive bibliometric and visual analysis research concerning BoNT-A treatment spasticity to elucidate current trends future directions in this area. A search was conducted Web Science database articles focused on use published between 2000 2022. We extracted various metrics, including counts publications contributions from different countries, institutions,...
BACKGROUND: There is little evidence on intra-articular (IA) treatment in knee osteoarthritis (KOA) and there a lack of long-term follow-up studies. OBJECTIVE: To assess the effectiveness safety IA oxygen-ozone (O2O3) hyaluronic acid (HA) terms functioning KOA patie nts over 31-week period. METHODS: Patients aged ⩾ 60 years with were randomly allocated to receive 4 injections (1/week) O2O3 or HA (T0–T3) visit weeks after fourth injection (T4). In this extension study we assessed VAS patients...
Fractures of femur proximal extremity (FFPE) are the most common fragility fractures requiring hospitalization, with a high risk mortality, low independence in activities daily living and severe consequences on health-related quality life. Timing for surgery has key role management elderly patients FFPE as recommended by Australian New Zealand guidelines National Institute Health Care Excellence guidelines. Early (within 48 h from hospital admission) allows significant benefits terms lower...
Rationale Factors associated with long-term sequelae emerging after the acute phase of COVID-19 (so called “long COVID”) are unclear. Here, we aimed to identify risk factors for development in a prospective cohort subjects hospitalized SARS-CoV-2 infection and followed up one year discharge. Methods A total 324 underwent comprehensive multidisciplinary evaluation hospital discharge COVID-19. subgroup 247/324 who consented donate blood sample were tested panel circulating cytokines. Results...
Objective: To investigate the effect of different adjunctive treatments after botulinum toxin type A. Design: Single-blind, randomized trial, with three-month follow-up. Setting: Secondary rehabilitative care. Subjects: Convenience sample 69 chronic hemiplegic adult patients spastic equinus foot. Interventions: Following A injection at plantar flexors, were randomly assigned to three groups and treated either taping, casting or stretching for one week, gait training next week. Outcome...
Background. The use of robots for gait training in Parkinson disease (PD) is growing, but no evidence points to an advantage over the standard treadmill. Methods. In this randomized, single-blind controlled trial, participants aged <75 years with early-stage PD (Hoehn-Yahr <3) were randomly allocated 2 groups: either 30 minutes on a treadmill or Lokomat 3 d/wk 4 weeks. Patients evaluated by physical therapist blinded allocation before and at end treatment then 3- 6-month follow-up....
Introduction. The clinical course of Coronavirus Disease 2019 (COVID-19) is highly heterogenous, ranging from asymptomatic to fatal forms. identification and laboratory predictors poor prognosis may assist clinicians in monitoring strategies therapeutic decisions. Materials Methods. In this study, we retrospectively assessed the prognostic value a simple tool, complete blood count, on cohort 664 patients ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>F</mi> </math> 260; 39%,...
Mental health-related symptoms can persist over time beyond the most common respiratory clinical features of COVID-19. A recent meta-analysis underlined that mental health sequalae may be relevant for COVID-19 survivors and reported following prevalence rates: 20% post-traumatic stress disorder, 22% anxiety, 36% psychological distress, 21% depression. In context a multi-disciplinary follow-up project, we already investigated mid-term (4 months) psychiatric outcomes in sample survivors....
Botulinum toxin type A (BoNT-A) is the treatment of choice for focal spasticity, with a concomitant effect on pain reduction and improvement quality life (QoL). Current evidence its efficacy based mainly post stroke spasticity. This study aims to clarify role BoNT-A in context non-stroke spasticity (NSS). We enrolled 86 patients affected by multiple sclerosis, spinal cord injury, traumatic brain injury clinical indication perform treatment. Subjects were evaluated before injection after 1,...
Background/Objectives: Breast cancer-related lymphedema (BCRL) is a significant complication of breast cancer (BC) treatment, characterized by swelling and fluid accumulation. Many risk factors have already been proven to be related BCRL; meanwhile, many others are still debated poorly investigated in the literature. This study potential involvement commonly prescribed chronic medications BCRL development. Methods: observational retrospective cohort included 162 post-surgical survivors...