A5040755081- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Extracellular vesicles in disease
- Food Allergy and Anaphylaxis Research
- Respiratory and Cough-Related Research
- Contact Dermatitis and Allergies
- Insect and Pesticide Research
- Cutaneous Melanoma Detection and Management
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Amyotrophic Lateral Sclerosis Research
- Melanoma and MAPK Pathways
- Dermatology and Skin Diseases
- Nanoplatforms for cancer theranostics
- Lysosomal Storage Disorders Research
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Insect Utilization and Effects
- Autoimmune Bullous Skin Diseases
- Ferroptosis and cancer prognosis
- Infectious Diseases and Mycology
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2021-2025
University of Turin
2015-2021
A. O. Ordine Mauriziano di Torino
2017-2019
Humanitas University
2019
Knowledge of the host response to novel coronavirus SARS-CoV-2 remains limited, hindering understanding COVID-19 pathogenesis and development therapeutic strategies. During course a viral infection, cells release exosomes other extracellular vesicles carrying components that can modulate immune response. The present study used shotgun proteomic approach map circulating exosomes’ infection. We investigated how infection modulates exosome content, involvement in disease progression, potential...
Aim To characterize elderly medical patients and identify factors associated with prolonged length of stay. Methods The present prospective observational study evaluated consecutive aged ≥65 years admitted in acute geriatric wards. A comprehensive assessment including demographic, clinical, functional cognitive variables was carried out. Delayed discharge defined when were discharged later than the date they deemed medically ready for by physicians. analysis initially out on total sample...
Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by the development of benign tumors in various organs, including brain, and often accompanied epilepsy, neurodevelopmental comorbidities intellectual disability autism. A key hallmark TSC hyperactivation mechanistic target rapamycin (mTOR) signaling pathway, which induces alterations cortical metabolic processes astrocytes, among other cellular functions. These changes could modulate seizure susceptibility,...
Oral eubiosis is of utmost importance for local and systemic health. Consolidated habits, as excessive alcohol consumption, smoke, inappropriate oral hygiene, western diet, exert detrimental effects on microbiota composition function. This leads to caries, gingivitis, periodontitis, also increasing the risk preterm births, inflammation, cancer. Thus, effective tools contain pathobiont overgrowth virulence restore are needed. Therefore, Limosilactobacillus reuteri LRE11, Lacticaseibacillus...
Ewing sarcoma (EWS) is an aggressive pediatric bone tumor characterized by unmet clinical needs and incompletely understood epigenetic heterogeneity. Here, we considered CD99, a major surface molecule hallmark of EWS malignancy. Fluctuations in CD99 expression strongly impair cell dissemination, differentiation, death. also loaded within extracellular vesicles (EVs), the delivery CD99-positive or CD99-negative EVs dynamically exerts oncogenic oncosuppressive functions to recipient cells,...
<b><i>Background:</i></b> Severe asthma is a heterogeneous disease, which characterized by airway damage and remodeling. All triggers of asthma, such as allergens, bacteria, viruses, pollutants, interact with the epithelial cells, drive inflammatory response through release cytokines, particularly IL-25, IL-33, thymic stromal lymphopoietin (TSLP). <b><i>Objectives Methods:</i></b> To investigate whether expression TSLP receptors on basophil...
Abstract Background Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical cellular systems has significantly understanding their immunobiology. Methods Five novel cell lines were obtained patient-derived biopsies MM in sino-nasal mucosa and designated as SN-MM1-5. The morphology, ultrastructure melanocytic identity SN-MM validated by...
Beer is one of the most widely consumed alcoholic beverage all over world. Although production and consumption this diffuse, allergic reactions are very uncommonly reported, mainly due to wheat, yeast or hops allergy. More recently, many foods drinks have been flavoured with spices, a reported increase in reactions. We report on case young woman who experienced anaphylaxis coriander-flavoured beer. This first beer coriander, which had added as aromatising substance. As presence flavours not...
β-Galactosylceramidase (GALC) is a lysosomal enzyme involved in sphingolipid metabolism by removing β-galactosyl moieties from β-galactosylceramide and β-galactosylsphingosine. Previous observations have shown that GALC may exert pro-oncogenic functions melanoma Galc silencing, leading to decreased oncogenic activity murine B16 cells. The tumor-driving BRAF(V600E) mutation present approximately 50% of human melanomas represents major therapeutic target. However, such missing Thus, assess the...
The study of the cancer secretome is gaining even more importance in cancers such as pancreatic ductal adenocarcinoma (PDAC), whose lack recognizable symptoms and early detection assays make this type highly lethal. wild-type p53 protein, frequently mutated PDAC, prevents tumorigenesis by regulating a plethora signaling pathways. tumor suppressive activity not only primarily involved within cells to limit cell proliferation but also extracellular space. Thus, loss has profound impact on...
Usefulness of Pidotimod and its role as immunostimulant, has been discussed, we know, for several decades. Nevertheless, there is still much to know. Understanding mechanisms potential usefulness in airway infections prevention, asthma both Th2 non type, bronchiectasis, adjuvant vaccination allergen immunotherapy remains clearly unveil. The aim this paper was provide a useful updated review the main available immunostimulants, giving particular focus on use potentials utility respiratory...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder lacking reliable biomarkers for early diagnosis and disease progression monitoring. This study aimed to identify the novel in plasmatic extracellular vesicles (EVs) isolated from ALS patients healthy controls (HCs). A total of 61 30 age-matched HCs were enrolled protein content circulating EVs was analyzed by shotgun proteomics. The divided into discovery phase (involving 12 HC patients) validation one 49 20...
Basophils are effector cells most often associated with airway inflammation in patients asthma and can have an important role the initiation of Th2 inflammation, as these may be activated directly by tissue cytokines (IL-25, IL-33 TSLP) released epithelial response to damage signals from allergens, bacterials, virus or pollutants. We investigated whether IL-25, TSLP receptors expression levels on basophil membrane phenotype. 24 (12 eosinophilic, 12 non eosinophilic) been enrolled study. IL25...