A5050126385- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- ECG Monitoring and Analysis
- Heart Rate Variability and Autonomic Control
- Dental Implant Techniques and Outcomes
- Infectious Diseases and Tuberculosis
- Cardiovascular Function and Risk Factors
- Cholesterol and Lipid Metabolism
- Cardiac Valve Diseases and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cancer, Lipids, and Metabolism
- Hematological disorders and diagnostics
- Medical Coding and Health Information
- Sports injuries and prevention
- Lipoproteins and Cardiovascular Health
- Inflammatory Myopathies and Dermatomyositis
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2020-2022
Vita-Salute San Raffaele University
2012-2022
IRCCS Ospedale San Raffaele
2013-2021
San Raffaele University of Rome
2011-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021
First Affiliated Hospital of Xi'an Jiaotong University
2019
Royal Brompton & Harefield NHS Foundation Trust
2019
Centro Cardiologico Monzino
2013
Università Cattolica del Sacro Cuore
2010
Catholic University of America
2008-2009
Late Potentials Ventricular Tachycardia Ablation . Rationale: To evaluate the efficacy of radiofrequency ventricular tachycardia (VT) ablation targeting complete late potential (LP) activity. Methods and Results: Sixty‐four consecutive patients (pts) with recurrent VTs coronary artery disease or idiopathic dilated cardiomyopathy were evaluated. Fifty (47 male; 66.2 ± 10.1 years) had LPs at electroanatomical mapping; 35 least 1 VT inducible basal programmed stimulation. After substrate...
We investigated the impact of catheter ablation on ventricular tachycardia (VT) recurrence and survival in a large number patients with structural heart disease treated setting dedicated multiskilled unit.Since January 2007, we have implemented multidisciplinary model, aiming for comprehensive management VT patients. Programmed stimulation was used to assess acute outcome. Primary end points were occurrence cardiac sudden death. Overall, 528 by (634 procedures; 1-4 procedures per patient)....
Background— The aim was to relate distinct scar distributions found in nonischemic cardiomyopathy with ventricular tachycardia (VT) morphology, late potential distribution, ablation strategy, and outcome. Methods Results— Eighty-seven patients underwent catheter for drug-refractory VT. Based on endocardial unipolar voltage, 44 were classified as predominantly anteroseptal 43 inferolateral. Anteroseptal more frequently fulfilled diagnostic criteria dilated (64% versus 36%), associated...
Successful late potential (LP) abolition and postprocedural ventricular tachycardia (VT) noninducibility constitute significant end points after catheter ablation for VT. We investigated the prognostic impact of a combined procedural point VT LP in large series post-myocardial infarction patients with VT.A total 160 (154 men, 94% implantable cardioverter defibrillators) consecutive undergoing first-time procedures from 2010 to 2012 were included. Of 159 surviving procedure, 137 (86%) either...
We report the experience in a cohort of consecutive patients receiving extracorporeal membrane oxygenation during catheter ablation unstable ventricular tachycardia (VT) at our center.From 2010 to 2015, was initiated 64 (average age: 63±15 years; left ejection fraction 27±9%; cardiogenic shock 23%, and electrical storm 62% patients) undergoing 74 VT procedures. At least one terminated 81% procedures with baseline inducible VT, noninducibility achieved 69%. Acute heart failure occurred 5...
Ventricular tachycardia (VT) with structural heart disease is dependent on reentry within scar regions. We set out to assess the VT circuit in greater detail than has hitherto been possible, using ultra-high-density mapping.All mapping guided ablation cases from 6 high-volume European centers were assessed. Maps analyzed offline generate activation maps of circuits. Topography, conduction velocity, and voltage complete maps.Thirty-six tachycardias 31 patients identified, 29 male 27 ischemic....
The mechanism of cardiac resynchronization therapy (CRT)-induced proarrhythmia remains unknown. We postulated that pacing from a left ventricular (LV) lead positioned on epicardial scar can facilitate re-entrant tachycardia. aim this study was to investigate the relationship between CRT-induced and LV location within scar.Twenty-eight 63 endocardial maps, obtained 64 CRT patients undergoing tachycardia ablation, were analyzed. A positive lead/scar relationship, defined as tip scar/border...
In patients with a prior myocardial infarction (MI), angiographic predictors of ventricular tachycardia (VT) recurrence after ablation are lacking. Recently, proarrhythmic effect chronic total occlusion (CTO) in coronary artery has been suggested.A 191 MI were referred to our Hospital between 2010 and June 2013 for first VT. Of these, 84 (44%) stable disease that underwent angiography during the index hospitalization included this study. A CTO an infarct-related (IRA-CTO) was present 47...
We present clinical, electroanatomical mapping (EAM), imaging, and catheter ablation (CA) strategies in patients with myocarditis-related ventricular tachycardia (VT). Between January 2010 July 2012, 26 consecutive underwent imaging-guided CA of arrhythmias, 23 using a combined endo–epicardial approach. Segment per segment correspondence late enhanced (LE) scar localization EAM was assessed all available uni/bipolar maps (n = 19). Induced VTs were targeted prior to substrate modification....
A new grid mapping catheter (GMC)-allowing for bipolar recordings of the electrograms in each orthogonal direction-became available. The aim current study is to evaluate utility GMC creating substrate and ventricular tachycardia (VT) activation maps during VT ablation procedures.From December 2017 July 2018, 41 consecutive patients undergoing a procedure using were studied. During mapping, 3 different created configurations (along spline, across HD wave solution); low voltage area late...
Background: The development of multielectrode mapping catheters has expanded the spectrum mappable ventricular tachycardias (VTs). Full diastolic pathway recording been associated with a high rate VT termination during radiofrequency ablation as well noninducibility at study end. However, role on recurrence yet to be clearly elucidated. We aimed explore complete activation recurrence. Methods: Eighty-five consecutive patients who underwent guided by high-density were enrolled. During...
Background— Catheter ablation is an important therapeutic option in postmyocardial infarction patients with ventricular tachycardia (VT). We analyzed the endo–epicardial electroanatomical mapping (EAM) voltage and morphology characteristics, their association clinical data prognostic value a large cohort of patients. Methods Results— performed total segmental analysis (bipolar dense scar [DS] low areas, unipolar penumbra areas) characteristics (presence abnormal late potentials [LPs] early...
Arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) is associated with arrhythmias, even without RV structural disease. We aimed to characterize the substrate using electroanatomical mapping and define outcomes following tachycardia (VT) ablation in patients abnormalities.Twenty-nine definite or suspected ARVC undergoing VT were classified as 'electrical' 'structural' based on absence presence of major criteria. Right endocardial epicardial assessment bipolar unipolar voltages,...
Epicardial approach in ventricular tachycardia (VT) ablation is still regarded as a second-step strategy, due to the risk of complications. We evaluated frequency that epicardial targets were identified and performed following pericardial access compared with unnecessary for different VT causes potential markers VT.
Catheter ablation of ventricular tachycardia (VT) is effective to prevent arrhythmia episode-related implantable cardioverter defibrillator shocks. However, recurrences in noninducible patients at programmed stimulation (PVS) are substantial.From May 2013 September 2015, 218 PVSs were performed 6 days (5-7) after (186 noninvasive stimulations and 32 invasive PVS) 210 consecutive (ischemic, 48%; median left ejection fraction, 37%; syncope, 35% with trauma associated 6%), while awake under...
In patients with an ischemic cardiomyopathy (ICM), the combination of late potential (LP) abolition and postprocedural ventricular tachycardia (VT) noninducibility is known to be desirable end point for a successful long-term outcome after VT ablation. We investigated whether LP noninducibilty have similar impact on outcomes non-ICMs (NICM) undergoing ablation.A total 403 NICM (523 procedures) who underwent ablation from 2010 2016 were included. The procedure points (if LPs absent, other...
Substrate-based approaches for ablation of unmappable ventricular tachycardia (VT) are strictly dependent on high-density mapping the scar. Ultra-high-density with multielectrode catheters facilitates an accurate and faster definition sites critical re-entry, due to possibility simultaneous recordings local potential from different pairs electrodes. Multipolar can be advanced map endocardial or epicardial surface. A strong correlation between scar area determined by electraoanatomical...
Background: Large-scale studies evaluating long-term recurrence rates in both idiopathic and non-idiopathic PVC catheter ablation (CA) patients have not been reported. Objective: To evaluate the efficacy safety of CA, investigating predictors acute efficacy. Methods: This retrospective multicentric study included 439 who underwent CA at three institutions from April-2015 to December-2021. Clinical success 6 months’ follow-up, defined as a reduction least 80% pre-procedural burden, was deemed...
Abstract Introduction Late potentials (LP) abolition is recognized as an effective strategy for substrate ablation of ventricular tachycardia (VT). The presence a chronic total occlusion in coronary artery responsible previous myocardial infarction (infarct related CTO, IRA‐CTO) emerging predictor arrhythmias and VT recurrence after ablation. We sought to analyze the effects LP abolition, focusing on high‐risk subgroup patients with IRA‐CTO. Methods results This was single‐center,...
To describe how a referral center for cardiac electrophysiology (EP) rapidly changed to comply with the ongoing COVID-19 healthcare emergency.We present retrospective data about modification of daily activities at our EP unit, following pandemic outbreak severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Italy. In particular, context pre-existing "hub-and-spoke" network, we procedure types and volumes have last 3 months.Since institution was selected as center, entire...