A5066064719- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Syncope and Autonomic Disorders
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Ophthalmology and Eye Disorders
- Vascular Anomalies and Treatments
- Botulinum Toxin and Related Neurological Disorders
- ECG Monitoring and Analysis
- Lipoproteins and Cardiovascular Health
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
Medtronic (United States)
2015-2024
Medtronic (Ireland)
2021-2024
Cleveland Clinic
2021
Medanta The Medicity
2015
Medical University of South Carolina
2013
In patients with symptomatic paroxysmal atrial fibrillation that has not responded to medication, catheter ablation is more effective than antiarrhythmic drug therapy for maintaining sinus rhythm. However, the safety and efficacy of cryoballoon as initial first-line have been established.
Pulsed field ablation uses electrical pulses to cause nonthermal irreversible electroporation and induce cardiac cell death. may have effectiveness comparable traditional catheter while preventing thermally mediated complications.The PULSED AF pivotal study (Pulsed Field Ablation Irreversibly Electroporate Tissue Treat AF) was a prospective, global, multicenter, nonrandomized, paired single-arm in which patients with paroxysmal (n=150) or persistent symptomatic atrial fibrillation (AF)...
Magnetic resonance imaging (MRI) of patients with conventional implantable cardioverter-defibrillators (ICD) is contraindicated.This multicenter, randomized trial evaluated safety and efficacy a novel ICD system specially designed for full-body MRI without restrictions on heart rate or pacing dependency. The primary objective was >90% freedom from MRI-related events composite endpoint within 30 days post-MRI. endpoints were ventricular capture threshold sensing amplitude.Subjects received...
Freedom from atrial arrhythmia (AA) recurrence ≥30 seconds after pulsed field ablation (PFA) in patients with fibrillation (AF) was reported PULSED AF (Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF; ClinialTrials.gov Identifier: NCT04198701). AA burden may be a more clinically meaningful endpoint.The purpose of this study determine the influence monitoring strategies on detection association quality life (QoL) health care utilization (HCU) PFA.Patients underwent...
Early recurrence of atrial tachyarrhythmias (ERAT) within 3 months thermal ablation for fibrillation (AF) is common and often considered transient. Pulsed field (PFA) a nonthermal energy source in which ERAT not well described. The purpose this study was to analyze patients with AF undergoing PFA the Field Ablation Irreversibly Electroporate Tissue Treat (PULSED AF) trial. This analysis included 154 (52.4%) paroxysmal 140 (47.6%) persistent who had ≥10 rhythm assessments during 90-day...
BackgroundData from randomized trials have suggested a modest or no effect of conventional cardiac resynchronization therapy (convCRT) on the incidence atrial fibrillation (AF). AdaptivCRT (aCRT, Medtronic, Mounds View, MN) is recently described algorithm for synchronized left ventricular (LV) pacing and continuous optimization (CRT).ObjectiveWe compared long-term effects aCRT with convCRT AF.MethodsThe Adaptive CRT trial CRT-defibrillator (CRT-D)–indicated patients (2:1) to receive either...
The use of systemic prostanoids in severe pulmonary arterial hypertension (PAH) is often limited by patient/physician dissatisfaction with the delivery methods. Complications associated external pump-delivered continuous therapy include IV catheter-related bloodstream infections and subcutaneous infusion site pain. We therefore investigated a fully implantable intravascular system for treprostinil infusion.A multicenter, prospective, single-arm, clinical trial (DelIVery Pulmonary Arterial...
Magnetic resonance imaging (MRI) can be safely performed in patients with magnetic (MR)-conditional pacemaker systems but remains relatively contraindicated non-MR-conditional systems.The purpose of this study was to evaluate the safety MRI without positioning restrictions an MR-conditional and currently a Medtronic CapSureFix Novus 5076 lead(s).The randomized 266 2:1 ratio group (177 patients) or control (89 patients). At 9-12 weeks postimplant, underwent at 1.5 T. Primary end points were...
Implantable cardioverter-defibrillators (ICDs) are underutilized in Asia, Latin America, Eastern Europe, the Middle East, and Africa. The Improve SCA Study is largest prospective study to evaluate benefit of ICD therapy underrepresented geographies. This analysis reports primary objective study.The objectives this was determine whether patients with prevention (PP) indications specific risk factors (1.5PP: syncope, nonsustained ventricular tachycardia, premature contractions >10/h, low...
The AdaptivCRT algorithm (aCRT) automatically adjusts atrioventricular delays each minute to achieve ventricular fusion through left (LV) or biventricular (BiV) pacing. aCRT is associated with superior clinical outcomes compared standard BiV pacing, but the association of and subsequent atrial fibrillation (AF) in a real-world population has not been fully evaluated.The purpose this study was investigate incidence AF ≥48 hours vs pacing after implant.Patients implanted cardiac...
Background Cardiac resynchronization therapy results in improved ejection fraction patients with heart failure. We sought to determine whether these effects were mediated by changes contractility, afterload, or volumes. Methods and Results In 610 New York Heart Association class I/ II failure from the Re synchronization Reverses Remodeling Systolic Left Ventricular Dysfunction ( REVERSE ) study, we performed detailed quantitative echocardiography assessment prior following cardiac therapy....
Despite available evidence that implantable cardioverter defibrillators (ICDs) reduce all-cause mortality among patients at risk for sudden cardiac death, utilization of ICDs is low especially in developing countries.To summarize reasons ICD or resynchronization therapy defibrillator implant refusal by arrest (Improve SCA) countries.Primary prevention (PP) and secondary (SP) from countries where use were enrolled. PP with additional factors (syncope, ejection fraction < 25%, nonsustained...
The development of treatments for heart failure (HF) is challenged by burdensome clinical trials. Reducing the need extensive data collection and increasing opportunities compatibility between trials may improve efficiency reduce resource burden. Heart Failure Collaboratory (HFC) multi-stakeholder consortium sought to create a lean case report form (CRF) use in HF evaluating cardiac devices. HFC convened patients, clinicians, researchers, U.S. Food Drug Administration (FDA), payers, industry...
Despite the burden of sudden cardiac arrest (SCA) worldwide, implantable cardioverter-defibrillators (ICDs) are underutilized, particularly in Asia, Latin America, Eastern Europe, Middle East, and Africa. The Improve SCA trial demonstrated that primary prevention (PP) patients these regions benefit from an ICD or a resynchronization therapy defibrillator (CRT-D). We aimed to compare rate device mortality among ischemic non-ischemic cardiomyopathy (ICM NICM) PP who met guideline indications...
Pulsed field ablation (PFA), a novel treatment for atrial fibrillation (AF), has yet to be evaluated in Japanese cohort.