A5008260213- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Pain Mechanisms and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Extracellular vesicles in disease
- Sepsis Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Cardiovascular Effects of Exercise
- Acute Ischemic Stroke Management
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Coronary Interventions and Diagnostics
- Viral Infections and Immunology Research
- Advanced Proteomics Techniques and Applications
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Biosensors and Analytical Detection
- Infant Nutrition and Health
- Gold and Silver Nanoparticles Synthesis and Applications
- Cardiomyopathy and Myosin Studies
Fudan University
2019-2025
Shanghai Chest Hospital
2021-2025
Shanghai Jiao Tong University
2022-2025
Huashan Hospital
2019-2025
New York University
2023
NYU Langone Health
2023
Rapid and accurate detection of myocardial infarction (MI) can boost the patient's chance survival. Surface enhanced Raman scattering (SERS) is an outstanding diagnostic technique because its strong light stability, high resolution, qualitative quantitative analysis based on characteristic fingerprint. However, reliability, stability specificity remain to be improved, especially in serum samples. In this study, we developed situ silver nanoparticles (Ag NPs) surface polydopamine (PDA) as a...
Abstract Pain is known to have sensory and affective components. The pain component encoded by neurons in the primary somatosensory cortex (S1), whereas emotional or experience large part processed neural activities anterior cingulate (ACC). timing of how a mechanical thermal noxious stimulus triggers activation peripheral fibers well-known. However, temporal processing nociceptive inputs remains little studied. Here, we took two approaches examine are S1 ACC. We simultaneously recorded...
Abstract Innate lymphoid cells (ILCs) are a class of lymphocytes that do not express specific antigen recognition receptors, which play significant role in various diseases due to their unique immunomodulatory functions. Among these, type 2 innate (ILC2s) form distinct subpopulation and recognized as key mediators anti-infective allergic responses. Cardiovascular leading cause intensive care unit admissions. diseases, including myocardial infarction heart failure, have complex pathogenesis...
Cardiac dysfunction is a serious complication of sepsis-induced multiorgan failure in intensive care units and characterized by an uncontrolled immune response to overwhelming infection. Type 2 innate lymphoid cells (ILC2s), as part the system, play crucial role inflammatory process heterogeneous cardiac disorders. However, ILC2 regulating its underlying mechanism remain unknown. The present study demonstrated that autophagic flux blockage exacerbated dysfunction, which was associated with...
Acute myocardial infarction (AMI) is usually caused by coronary thrombosis. However, the short half-life, lack of targetability and inevitable ischemia/reperfusion injury secondary to revascularization, which characterizes tissue plasminogen activator (tPA) limit its thrombolytic efficacy for AMI. To address targeted site-specific delivery tPA, current study reports construction a thrombus-targeting responsive biomimetic nanoparticle (PTPN) spatiotemporal treatment PTPN was constituted...
Background Sepsis-induced cardiomyopathy ( SIC ) is one major cause of death for sepsis but lacks timely diagnosis and specific treatment due to unclear mechanisms. Lipocalin-2 (LCN-2) a key regulator lipid metabolism which has been recently proved closely related sepsis, however, the relationship between LCN-2 septic myocardial injury remains unknown. We aim explore role in pathological progress based on clinical laboratory evidence. Methods Consecutive patients admitted intensive care unit...
Abstract Negative pain expectation including catastrophizing is a well-known clinical phenomenon whereby patients amplify the aversive value of painful or oftentimes even similar, non-painful stimulus. Mechanisms catastrophizing, however, remain elusive. Here, we modeled behavior in rats, and found that rats subjected to repeated noxious pin pricks on one paw demonstrated an response similar but non-noxious mechanical stimuli delivered contralateral paw. Optogenetic inhibition pyramidal...
Cardiac involvement is commonly present in various neuromuscular diseases which may develop life-threatening consequences. The early manifestation often asymptomatic however has been insufficiently studied.We aim to characterize electrocardiographic (ECG) changes without cardiac symptoms.Adults having genetically and/or pathologically confirmed type 1 myotonic dystrophy (DM1), Becker muscular (BMD), limb girdle dystrophies (LGMDs) and mitochondrial (MtDs) but history of heart cardiovascular...
Abstract Background Sepsis-induced myocardial injury is a serious complication of sepsis. QT prolongation proarrhythmic state which reflects in group heterogeneous disorders. However, the study on clinical value sepsis limited. Methods We aimed to investigate characteristics and predictors new-onset its impact outcome multicenter retrospective cohort study. Electrocardiographic data were collected from patients with wards intensive care units four centers after exclusion QT-influencing...
Background: The prominent mitochondrial metabolic changes of the atrium reportedly have significant impact on electrical signals and structural remodeling which play important roles in occurrence development atrial fibrillation (AF). However, mechanism is not completely known. Objective: This study was aimed to explore metabolism reprogrammed AF patients by integrating metabolomics as well proteomics human tissues. Methods Results: Left tissue samples were harvested from 10 non-valvular...
Abstract Introduction Acute pulmonary vein reconnection (PVR) via epicardial fibers can be found during observation period after PV isolation, the characteristics and related factors have not been fully studied. We aimed to investigate prevalence, locations, electrogram characteristics, ablation parameters acute (AEPVR). Methods PVR was monitored isolation. AEPVRs were mapped distinguished from endocardial conduction gaps. The clinical, electrophysiological lesion set compared between...
An Isoproterenol Dependent Broad QRS Tachycardia: What is the Mechanism?Weizhuo Liu MD1, Nanqing Xiong MD2*, Wentao Gu MD21. Department of Critical Care Medicine, Shanghai Chest Hospital, Jiaotong University, 241 West Huaihai Road, 200030, China2. Cardiology, Huashan Hospital Fudan 12 Wulumuqizhong 200040, China*Corresponding author: MD, China. E-mail: huashancardio@163.comKey words: wide complex tachycardia, intermittent preexcitation, Wolff-Parkinson-White syndrome, antidromic AV reentrant...
Different brain areas have distinct roles in the processing and regulation of pain thus may form specific pharmacological targets. Prior research has shown that AMPAkines, a class drugs increase glutamate signaling, can enhance descending inhibition from prefrontal cortex (PFC) nucleus accumbens. On other hand, activation neurons anterior cingulate (ACC) is known to produce aversive component pain. The impact AMPAkines on ACC, however, not known. We found direct delivery CX516, well-known...
The comprehensive characterization of N-glycans is significant importance for the discovery potential biomarkers and diagnosis therapy diseases. Herein, we designed fabricated a porous graphitized carbon biomaterial (CS-900-1C) using cheap available chitosan as source via facile pyrolysis process post-oxidation strategy effective capture N-glycans. Thanks to its large surface area (2846 m2 g-1), high graphitization degree, suitable oxidation degree unique structure, CS-900-1C exhibits an...
Background. Far-field electrograms from superior vena cava (SVC) can be present in right pulmonary vein (RSPV) after (PV) isolation. Objectives. To analyze the characteristics of far-field SVC potentials RSPV PV isolation and local anatomy difference between patients with without potentials. Methods. Patients undergoing were retrospectively reviewed, contrast-enhanced computed tomography (CT) was performed before procedure for observing anatomical relationship SVC. The prevalence described...
Background Ablation of accessory pathway from the region anterolateral tricuspid annulus remains most challenging although multiple approaches have been introduced. Objective To evaluate feasibility a sequential supra-to-subvalvular approach for mapping and ablation right pathway. Methods Cases were reviewed divided into group A (conventional approach) B (sequential comparison. In B, initial radiofrequency delivery was performed in atrium along annulus, with target marked on 3D map....
Uncontrolled inflammation storm induced by sepsis may lead to severe organ dysfunction and secondary immunosuppression, which is one of the main reasons for high mortality prolonged hospitalization septic patients. However, there a lack effective treatments it at present. Here, we report an efferocytosis-inspired nanodrug (BCN@M) treat immunosuppression via regulating macrophage function. Bioactive molecular curcumin was loaded with bovine serum albumin then coated damaged erythrocyte...
Background Acute pulmonary vein reconnection via epicardial fibers can be found during observation period after PV isolation, the characteristics and related factors have not been fully studied. Objective To investigate prevalence, locations, electrogram ablation parameters to acute (AEPVR). Methods PVR was monitored from which AEPVRs were mapped distinguished endocardial conduction gaps. The clinical, electrophysiological lesion set compared between patients with without PVR. So they among...