A5011901934- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Adenosine and Purinergic Signaling
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Synthesis and biological activity
- Chemokine receptors and signaling
- Infrared Target Detection Methodologies
- Pregnancy and Medication Impact
- Tryptophan and brain disorders
- Exercise and Physiological Responses
- Dermatology and Skin Diseases
- COVID-19 Clinical Research Studies
- Graphene and Nanomaterials Applications
- FOXO transcription factor regulation
- Advanced SAR Imaging Techniques
Center for Life Sciences
2024
Tsinghua University
2024
Shanghai Skin Disease Hospital
2021-2024
Tongji University
2019-2024
Weifang People's Hospital
2024
Weifang Medical University
2024
Shanghai Tenth People's Hospital
2019-2023
Central Hospital of Putuo District
2023
Institute for Biomedical Engineering
2019-2022
Tongji Hospital
2020-2022
The metabolite adenosine plays an important immunosuppressive role in the tumor microenvironment (TME) through its ligation with metabolic checkpoint 2A receptor (A2AR). Here, adenosine-A2AR negative feedback pathway is highlighted during photothermal-induced immunogenic cell death (ICD). Adenosine, hydrolyzed from ATP, amplified ICD process. It possible to achieve a robust ICD-based immunotherapy via targeting pathway. In this regard, A2AR inhibitor-loaded polydopamine nanocarrier masked by...
Lactate plays a critical role in tumorigenesis, invasion and metastasis. Exhausting lactate tumors holds great promise for the reversal of immunosuppressive tumor microenvironment (TME). Herein, we report on "lactate treatment plant" (i.e., nanofactory) that can dynamically trap pro-tumor situ transformation into anti-tumor cytotoxic reactive oxygen species (ROS) synergistic chemodynamic metabolic therapy. To this end, oxidase (LOX) was nano-packaged by cationic polyethyleneimine (PEI),...
Lactate accumulation in the solid tumor is highly relevant to immunosuppressive microenvironment (TME). Targeting lactate metabolism significantly enhances efficacy of immunotherapy. However, depletion by oxidase (LOX) consumes oxygen and results aggravated hypoxia situation, counteracting benefit depletion. Beyond TME regulation, it necessary initiate effective immunity cycle for therapeutic purposes. In this fashion, dual close-loop catalyzed immune response a rational material design are...
Hypoxia and high accumulation of lactic acid in the tumor microenvironment provide fertile soil for development, maintenance metastasis. Herein, we developed a calcium peroxide (CaO2)-loaded nanostructure that can play role "one stone kill two birds", i.e., acidic hypoxic be simultaneously regulated by CaO2 loaded nanostructure. Specifically, CaO2-loaded mesoporous polydopamine nanoparticles modified with sodium hyaluronate (denoted as CaO2@mPDA-SH) gradually accumulate site. exposed succeed...
Acute myocardial infarction (AMI) is usually caused by coronary thrombosis. However, the short half-life, lack of targetability and inevitable ischemia/reperfusion injury secondary to revascularization, which characterizes tissue plasminogen activator (tPA) limit its thrombolytic efficacy for AMI. To address targeted site-specific delivery tPA, current study reports construction a thrombus-targeting responsive biomimetic nanoparticle (PTPN) spatiotemporal treatment PTPN was constituted...
Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seriously threatening human health. Following SARS-CoV-2 infection, immune cell infiltration creates an inflammatory and oxidative microenvironment, which can cause pneumonia, syndrome, kidney failure, even death. Clinically, a safe effective treatment strategy remains to be established. Herein, nano-bait for inhibition of infection redirecting viral attack while...
Antigen self-assembly nanovaccines advance the minimalist design of therapeutic cancer vaccines, but issue inefficient cross-presentation has not yet been fully addressed. Herein, we report a unique approach by combining concepts "antigen multi-copy display" and "calcium carbonate (CaCO3) biomineralization" to increase cross-presentation. Based on this strategy, successfully construct sub-100 nm biomineralized antigen nanosponges (BANSs) with high CaCO3 loading (38.13 wt%) density (61.87%)....
Methionine metabolism has a significant impact on T cells' survival and activation even in comparison to arginine, well-documented amino acid metabolic therapy. However, hydrophilic methionine is hardly delivered into TME due difficult loading rapid diffusion. Herein, the labeling assembly of nanoparticle developed overcome high hydrophilicity for mild-heat mediated immunometabolic The strategy first label with protocatechualdehyde (as tag) via reversible Schiff-base bond, then drive...
To investigate the relationship between FKBP prolyl isomerase 5 (FKBP5) gene expression and CD8 T cells in tumour progression immunology of luminal B subtype breast cancer (LBBC) using bioinformatics analyses.The Gene Expression Profiling Interactive Analysis 2, Human Protein Atlas gene-expression miner v4.5 databases were used for data mining analysing FKBP5, its co-expressed genes cell-related markers. The Tumor IMmune Estimation Resource 2.0 database was correlation prognosis FKBP5 cell...
Cell metabolite adenosine can induce extensive and persistent immunosuppression by binding to receptors on immune cells. Seriously, the hypoxia‐driven adenosinergic axis aggravates accumulation via dephosphorizing immune‐activating triphosphate (ATP) released during immunogenic cell death (ICD). Different from direct clearance or receptor blockade directly using ecto‐enzyme (CD39/CD73) antagonist, it is hoped use an innovative small science engineering regulate upstream hypoxia/HIF‐1α signal...