A5057939103- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Palliative Care and End-of-Life Issues
- Anesthesia and Neurotoxicity Research
- Ethics in medical practice
- Eating Disorders and Behaviors
- Cardiac, Anesthesia and Surgical Outcomes
- Patient Dignity and Privacy
- Healthcare Decision-Making and Restraints
- Dementia and Cognitive Impairment Research
- Obsessive-Compulsive Spectrum Disorders
- Treatment of Major Depression
- Family and Patient Care in Intensive Care Units
- Schizophrenia research and treatment
- Frailty in Older Adults
- Electroconvulsive Therapy Studies
- Pharmaceutical Practices and Patient Outcomes
- Geriatric Care and Nursing Homes
- Animal Behavior and Welfare Studies
- Genetic and phenotypic traits in livestock
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Evolutionary Psychology and Human Behavior
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Regulation of Appetite and Obesity
Hebrew SeniorLife
2015-2025
Harvard University
2015-2025
Beth Israel Deaconess Medical Center
2015-2025
Hebrew College
2020-2024
Brown University
2014-2021
KU Leuven
2021
University of Massachusetts Chan Medical School
2021
University of Washington
2014
Harvard University Press
2012
Hadassah Medical Center
2002-2003
This article has been corrected. The original version (PDF) is appended to this as a Supplement. Background: Delirium common, leads other adverse outcomes, and costly. However, it often remains unrecognized in most clinical settings. Confusion Assessment Method (CAM) the widely used diagnostic algorithm, operationalizing its features would be substantial advance for care. Objective: To derive 3D-CAM, new 3-minute assessment CAM-defined delirium, validate against reference standard. Design:...
Objectives To examine associations between the inflammatory marker C‐reactive protein ( CRP ) measured preoperatively and on postoperative day 2 POD 2) delirium incidence, duration, feature severity. Design Prospective cohort study. Setting Two academic medical centers. Participants Adults aged 70 older undergoing major noncardiac surgery (N = 560). Measurements Plasma was using enzyme‐linked immunosorbent assay. Delirium assessed from Confusion Assessment Method CAM interviews chart review....
Gabapentin has been increasingly used as part of a multimodal analgesia regimen to reduce opioid use in perioperative pain management. However, the safety gabapentin among older patients remains uncertain.To examine in-hospital adverse clinical events associated with undergoing major surgery.This retrospective cohort study using data from Premier Healthcare Database included aged 65 years or who underwent surgery at US hospitals within 7 days hospital admission January 1, 2009, March 31,...
Objectives To describe baseline characteristics and quality assurance procedures of the Successful Aging after Elective Surgery ( SAGES ) study, which was designed to examine novel risk factors long‐term outcomes associated with delirium. Design Long‐term prospective cohort study. Setting Three academic medical centers. Participants Individuals aged 70 older (average age 77, 58% female) without recognized dementia scheduled for elective major surgery (N = 566). Measurements were assessed...
Major depressive disorder (MDD) is a worldwide cause of disability in older age, especially during the covid pandemic. Transcranial direct current stimulation (tDCS) non-invasive neuromodulation technique that has shown encouraging efficacy for treatment depression. Here, we investigate feasibility an innovative protocol where tDCS administered within homes adults with MDD (patient participants) help study companion (i.e. caregiver). We further analyze remotely-hosted training program...
Abstract Introduction Older adults, including those with mild cognitive impairment (MCI), are increasingly undergoing surgery. Methods Relative risks (RRs) of MCI alone or delirium on adverse outcomes were estimated in an ongoing prospective, observational cohort study 560 nondemented adults aged ≥70 years. Results (n = 61, 11%) was associated increased RR (RR 1.9, P < .001) and severity 4.6, .001). Delirium 107), but not 34), multiple more major postoperative complication(s) 2.5, .002)...
Abstract Postoperative delirium is the most common complication among older adults undergoing major surgery. The pathophysiology of poorly understood, and no blood-based, predictive markers are available. We characterized plasma metabolome 52 cases matched controls from Successful Aging after Elective Surgery (SAGES) cohort (N = 560) patients ≥ 70 years old without dementia scheduled non-cardiac applied targeted mass spectrometry with internal standards pooled using a nested case-control...
Importance The 2014 Improving Medicare Post-Acute Care Transformation (IMPACT) Act aimed to improve postacute care quality and outcomes. This study examines changes in delirium, a key indicator, over 5 years following its implementation. Objective To compare the persistence resolution of delirium within skilled nursing facilities (SNFs) between 2019. Design, Setting, Participants cross-sectional included SNF admissions from 5% random sample, with assessments conducted January 1 December 31...
The eating disorder bulimia nervosa has been associated with impaired satiety, decreased resting metabolic rate, and abnormal neuroendocrine regulation. Preclinical studies suggest that such alterations could be leptin function. Thus, the goal of this study was to assess whether function is in nervosa. Serum levels measured women (n = 18) who had maintained stable recovery from 15) were compared values healthy female controls 20). Subjects studied during follicular phase their menstrual...
The objective of this analysis was to develop a measure neuropsychological performance for cardiac surgery and assess its psychometric properties. Older patients (n = 210) underwent battery using nine assessments. number factors identified with variable reduction methods. Factor methods based on item response theory were used evaluate the measure. Modified parallel supported single factor, formed an internally consistent set (coefficient alpha .82). developed provided reliable, continuous...
To investigate the effect of postoperative delirium on longitudinal brain microstructural changes, as measured by diffusion tensor imaging.We studied a subset larger Successful Aging after Elective Surgery (SAGES) study cohort older adults (≥70 years) without dementia undergoing elective surgery: 113 participants who had imaging before and 1 year surgery. Postoperative severity occurrence were assessed during hospital stay using Confusion Assessment Method validated chart review method. We...
Objective Neuropsychological test batteries are administered in person to assess cognitive function both clinical and research settings. However, in‐person administration holds a number of logistical challenges that makes it difficult use large or remote populations for multiple serial assessments over time . The purpose this descriptive study was determine whether telephone‐administered neuropsychological battery correlated well with testing. Methods Fifty English‐speaking patients without...