A5102966996- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Advanced NMR Techniques and Applications
- Transplantation: Methods and Outcomes
- Nuclear Physics and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Acute Kidney Injury Research
- Quantum, superfluid, helium dynamics
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Medical Imaging Techniques and Applications
- Ultrasound in Clinical Applications
- Organ Transplantation Techniques and Outcomes
- Electron Spin Resonance Studies
- Renal and Vascular Pathologies
- Renal Transplantation Outcomes and Treatments
- Photoacoustic and Ultrasonic Imaging
- Liver Disease Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Viral Infections and Immunology Research
Medizinische Hochschule Hannover
2016-2025
German Center for Lung Research
2016-2025
Otto-von-Guericke University Magdeburg
2024-2025
University Hospital Magdeburg
2024
Deutsches Herzzentrum der Charité
2010-2023
Society of Interventional Radiology
2014-2019
Siemens (Germany)
2019
University of Florida
2018
Columbus Oncology and Hematology Associates
2018
National Taiwan University Hospital
2013
Purpose In this feasibility study, a phase‐resolved functional lung imaging postprocessing method for extraction of dynamic perfusion (Q) and ventilation (V) parameters using conventional 1H MRI Fourier decomposition acquisition is introduced. Methods Time series coronal gradient‐echo MR images with temporal resolution 288 to 324 ms two healthy volunteers, one patient chronic thromboembolic hypertension, cystic fibrosis, obstructive pulmonary disease were acquired at 1.5 T. Using sine model...
Abstract Objectives This study aimed at developing technical recommendations for the acquisition, processing and analysis of renal ASL data in human kidney 1.5 T 3 field strengths that can promote standardization perfusion measurements facilitate comparability results across scanners multi-centre clinical studies. Methods An international panel 23 experts followed a modified Delphi process, including on-line surveys two in-person meetings, to formulate series consensus statements regarding...
Renal ischemia reperfusion injury leads to acute kidney (AKI) and is associated with tissue edema, inflammatory cell infiltration, subsequent development of interstitial renal fibrosis tubular atrophy. The purpose this study was investigate the value functional magnetic resonance imaging (MRI) techniques, T2 mapping, diffusion-weighted (DWI) in characterizing chronic pathology after unilateral AKI mice.Moderate or severe AKIs were induced C57Bl/6 mice through transient clamping pedicle for...
Purpose To combine diffusion‐weighted imaging (DWI) and diffusion tensor (DTI) for detection of allograft dysfunction in patients early after kidney transplantation to correlate parameters with renal function histology biopsies. Materials Methods Between day 4 11 33 initial graft 31 delayed (DGF) were examined a 1.5T magnetic resonance (MRI) scanner. DTI DWI sequences acquired fractional anisotropy (FA), apparent coefficient (ADCmono), pure (ADC diff ), the perfusion fraction (Fp)...
The aim of this study was to investigate whether magnetic resonance (MR) diffusion tensor imaging (DTI) allows assessment renal pathologies in a rat model diabetic nephropathy.Twenty-one male Sprague-Dawley rats were divided into 3 groups: (1) untreated controls, (2) diabetes (DM), (3) with uninephrectomy (DM UNX) accelerate impairment. Eight weeks after induction streptozotocin, MR performed 1.5-T scanner using an 8-channel wrist coil. Morphological proton density images and echoplanar DTI...
Background Perfusion‐weighted (Qw) noncontrast‐enhanced proton lung MRI is a promising technique for assessment of pulmonary perfusion, but still requires validation. Purpose To improve perfusion‐weighted phase‐resolved functional (PREFUL)‐MRI, to validate PREFUL with perfusion single photon emission computed tomography (SPECT) as gold standard, and compare dynamic contrast‐enhanced (DCE)‐MRI reference. Study Type Retrospective. Population Twenty patients chronic obstructive disease (COPD),...
Abstract A new approach for utilizing conjugate k ‐space symmetry improved parallel MRI performance is presented. By generating virtual coils containing symmetric signals from actual coils, additional image‐ and coil‐phase information can be incorporated into the reconstruction process acquisition techniques. In that way conditions are improved, resulting in less noise enhancement. particular combination with generalized autocalibrating partially acquisitions (GRAPPA), coil concept...
Purpose To determine if arterial spin-labeling (ASL) magnetic resonance (MR) imaging can show serial changes in renal perfusion mice with ischemia-induced acute kidney injury (AKI) and to compare results those of histologic examination inulin para-aminohippuric acid (PAH) clearance. Materials Methods In this animal care committee–approved study, AKI was induced C57Bl/6 (n = 26) by clamping the right pedicle for 35 minutes moderate 16) or 45 11) severe AKI. Renal measured 10 animals seven...
Purpose To quantify regional lung ventilation in patients with chronic obstructive pulmonary disease (COPD) by using free-breathing dynamic fluorinated (fluorine 19 [19F]) gas magnetic resonance (MR) imaging. Materials and Methods In this institutional review board-approved prospective study, 27 COPD were examined breath-hold 19F wash-in MR imaging during inhalation of a normoxic mixture (perfluoropropane) washout after the was finished for total 25-30 L. Regional quantified volume defect...
Purpose To evaluate surgical success after pulmonary endarterectomy (PEA) by means of cardiopulmonary magnetic resonance (MR) imaging. Materials and Methods In this institutional review board–approved study, 20 patients with chronic thromboembolic hypertension were examined at 1.5 T a dynamic contrast material–enhanced three-dimensional fast low-angle shot sequence before 12 days PEA (25th–75th percentile range, 11–16 days). Lung segments evaluated visually for parenchymal hypoperfused...
Objectives The aims of this experimental study were to investigate renal allograft pathophysiology by multiparametric functional magnetic resonance imaging (MRI) and directly correlate MRI parameters with histopathology in mouse models allogenic isogenic kidney transplantation (ktx). Materials Methods Allograft rejection was induced C57BL/6 (B6) donor kidneys into BALB/c recipients (allogenic ktx). B6 mice that received served as controls (isogenic Three weeks after ktx, performed using a...
Purpose To compare low‐pass imaging dynamic acquisitions (LIDA) approach in combination with a group‐oriented registration (GOREG) scheme conventional Fourier decomposition (FD). Methods Dynamic images of six healthy volunteers and one chronic obstructive pulmonary disease (COPD) patient were acquired on 1.5 Tesla scanner using spoiled gradient echo sequence. For the each slice was during regular (RB) irregular breathing (IB). (CR), all directly registered to intermediate respiratory...
Purpose To test the feasibility of 3D phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and patients with chronic pulmonary disease, to compare 2D PREFUL, investigate required temporal resolution obtain stable PREFUL measurement. Methods Sixteen participants underwent using PREFUL. Retrospectively, spatial (4 × 4 mm 3 ) was decreased match 15 ), abbreviated as lowres . In addition regional ventilation (RVent), flow‐volume loops were computed rated by a cross‐correlation (CC)....
To test the feasibility of regional fully quantitative ventilation measurement in free breathing derived by phase-resolved functional lung (PREFUL) MRI supine and prone positions. In addition, influence T2 * relaxation time on quantification is assessed.Twelve healthy volunteers underwent at 1.5 T using a 2D triple-echo spoiled gradient echo sequence allowing for time. Minute (ΔV) was quantified conventional fractional (FV) newly introduced (VR), which corrects volume errors due to image...
Background Non‐contrast‐enhanced 1 H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional ventilation but a comparison direct measurement using 19 F MRI is lacking. Purpose To compare parameters calculated 3D phase‐resolved functional (PREFUL) MRI. Study Type Prospective. Population Fifteen patients asthma, 14 chronic obstructive disease, and 13 healthy volunteers. Field Strength/Sequence A gradient‐echo pulse sequence golden‐angle increment...
Abstract Purpose Pulmonary MRI faces challenges due to low proton density, rapid transverse magnetization decay, and cardiac respiratory motion. The fermat‐looped orthogonally encoded trajectories (FLORET) sequence addresses these issues with high sampling efficiency, strong signal, motion robustness, but has not yet been applied phase‐resolved functional lung (PREFUL) MRI—a contrast‐free method for assessing pulmonary ventilation during free breathing. This study aims develop a...
Abstract Background Metasurface coils (MCs) are a promising magnetic resonance imaging (MRI) technology. Aiming to evaluate the image quality of MCs for knee and elbow imaging, we compared signal-to-noise ratio (SNRs) obtained in standard clinical setups. Methods Knee MRI routine sequences were applied at 1.5 T, implementing four coil scenarios: (1) 15-channel transmit/receive coil; (2) four-channel multipurpose (flex coil); (3) MC + spine (4) coil. Three regions interest (ROIs) different...
<title>Abstract</title> Microwave ablation (MWA) of hepatic tumors benefits from MR thermometry, enabling real-time temperature monitoring to guide treatment and protect healthy tissue. However, thermometry in the abdomen is challenging due respiratory intestinal motion. This study evaluates two advanced 3D imaging sequences, Stack-of-Stars (Stars) Stack-of-Spirals (Spirals), for precise MWA phantom volunteer experiments. Spirals demonstrated superior precision, with a standard deviation...
Perfusion-weighted noncontrast-enhanced proton lung MRI during free breathing is maturing as a novel technique for assessment of regional perfusion, but has not yet been validated in chronic obstructive pulmonary disease (COPD) patients.To compare parenchymal perfusion assessed by perfusion-weighted phase-resolved functional (PREFUL)-MRI with determined dynamic gadolinium-enhanced (DCE)-MRI and function test parameters.Prospective.A single-center subset the COPD cohort "COPD SYstemic...