A5072325586- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Atomic and Subatomic Physics Research
- Advanced X-ray and CT Imaging
- Soft Robotics and Applications
- Medical Imaging Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Surgical Simulation and Training
- MRI in cancer diagnosis
- Acute Kidney Injury Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Radiation Dose and Imaging
- Augmented Reality Applications
- Advanced NMR Techniques and Applications
- Anatomy and Medical Technology
- Nutrition and Health in Aging
- Advanced Radiotherapy Techniques
- Bladder and Urothelial Cancer Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Infrared Thermography in Medicine
- Wireless Body Area Networks
- Nuclear Physics and Applications
- Renal and Vascular Pathologies
- Micro and Nano Robotics
Medizinische Hochschule Hannover
2016-2025
Otto-von-Guericke University Magdeburg
2018-2025
University Hospital Magdeburg
2024
German Center for Lung Research
2023
RELX Group (United States)
2018
Objectives The aims of this experimental study were to investigate renal allograft pathophysiology by multiparametric functional magnetic resonance imaging (MRI) and directly correlate MRI parameters with histopathology in mouse models allogenic isogenic kidney transplantation (ktx). Materials Methods Allograft rejection was induced C57BL/6 (B6) donor kidneys into BALB/c recipients (allogenic ktx). B6 mice that received served as controls (isogenic Three weeks after ktx, performed using a...
Abstract Background Metasurface coils (MCs) are a promising magnetic resonance imaging (MRI) technology. Aiming to evaluate the image quality of MCs for knee and elbow imaging, we compared signal-to-noise ratio (SNRs) obtained in standard clinical setups. Methods Knee MRI routine sequences were applied at 1.5 T, implementing four coil scenarios: (1) 15-channel transmit/receive coil; (2) four-channel multipurpose (flex coil); (3) MC + spine (4) coil. Three regions interest (ROIs) different...
<title>Abstract</title> Microwave ablation (MWA) of hepatic tumors benefits from MR thermometry, enabling real-time temperature monitoring to guide treatment and protect healthy tissue. However, thermometry in the abdomen is challenging due respiratory intestinal motion. This study evaluates two advanced 3D imaging sequences, Stack-of-Stars (Stars) Stack-of-Spirals (Spirals), for precise MWA phantom volunteer experiments. Spirals demonstrated superior precision, with a standard deviation...
Abstract Background Navigation support in interventional magnetic resonance imaging (MRI) is separated from the operating field, which makes it difficult to interpret positions and orientations coordinate necessary hand movements. Methods We developed a projector‐based augmented reality system enable visual navigation of tracked instruments on pre‐planned paths visualization risk structures directly patient inside MRI bore. To assess accuracy system, user study was carried out with...
Abstract Purpose In vivo studies are often required to prove the functionality and safety of medical devices. Clinical trials costly complex, adding ethical scrutiny animal testing. Anthropomorphic phantoms with versatile functionalities can overcome these issues regard education or an effective development assistance systems during image-guided interventions (e.g., robotics, navigation/registration algorithms). this work, MRI-compatible customizable motion phantom is presented mimic...
Abstract Introduction Advanced or metastatic soft tissue sarcoma (a/mSTS) is associated with a dismal prognosis. Patient counseling on treatment aggressiveness pivotal to avoid over- undertreatment. Recently, evaluation of body composition markers like the skeletal muscle index (SMI) became focus interest in variety cancers. This study focuses prognostic impact SMI a/mSTS, retrospectively. Methods 181 a/mSTS patients were identified, 89 eligible due prespecified criteria for assessment....
Magnetic Resonance (MR) thermometry is used for the monitoring of MR-guided microwave ablations (MWA), and intraoperative evaluation ablation regions. Nevertheless, accuracy temperature mapping may be compromised by electromagnetic interference emanating from (MW) generator. This study evaluated different setups improving magnetic resonance imaging (MRI) during MWA with a modified MW was performed in 15 gel phantoms comparing three setups: The generator placed outside MR scanner room, either...
During MRI-guided interventions, navigation support is often separated from the operating field on displays, which impedes interpretation of positions and orientations instruments inside patient's body as well hand-eye coordination. To overcome these issues projector-based augmented reality can be used to needle guidance MRI bore directly in field. The authors present two visualisation concepts for aids were compared an accuracy usability study with eight participants, four whom experienced...
Abstract Purpose Surgical robotics have demonstrated their significance in assisting physicians during minimally invasive surgery. Especially, the integration of haptic and tactile feedback technologies can enhance surgeon’s performance overall patient outcomes. However, current state-of-the-art lacks such interaction opportunities, especially robotic-assisted interventional magnetic resonance imaging (iMRI), which is gaining importance clinical practice, specifically for percutaneous needle...
Background: The introduction of checkpoint inhibitors is a long-awaited new option for urothelial cancer with poor prognosis. Apart from clinical studies, the data on real world experience scarce. Methods: Patients monotherapy either Atezolizumab, Nivolumab or Pembrolizumab after chemotherapy were included. Adverse events and immune related adverse as well survival imaging analyses recorded in prospectively designed multi-center base. Duration response, progression free (PFS), overall (OS)...
Acute kidney injury (AKI) frequently complicates major surgery and can be associated with hypertension progress to chronic disease, but reports on blood pressure normalization in AKI are conflicting. In the present study, we investigated effects of an angiotensin-converting enzyme inhibitor, enalapril, a soluble epoxide hydrolase 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea (TPPU), renal inflammation, fibrosis, glomerulosclerosis mouse model ischemia-reperfusion (IRI)-induced...
To share our experience using transurethral ultrasound ablation (TULSA) treatment for focal therapy of localized prostate cancer (PCa).Between 10/2019 and 06/2021 TULSA PCa was performed in 22 men (mean age: 67 ± 7 years, mean initial PSA: 6.8 2.1 ng/ml, ISUP 1 n = 6, 2 14 patients with recurrence after previous radiotherapy). Patients were selected by an interdisciplinary team, taking clinical parameters, histopathology from targeted or systematic biopsies, mpMRI preferences into...
129Xe hyperpolarized gas chemical exchange saturation transfer (HyperCEST) MRI has been suggested as molecular imaging modality but translation to in vivo slow, likely due difficulties of synthesizing suitable molecules. Cucurbit[6]uril-either readily available non-functionalized or potentially functionalized form-may, combined with HyperCEST MRI, prove useful a switchable MR contrast agent the differential properties generation individual compartments well influence signal drifts...
To characterize ischemia reperfusion injury (IRI)-induced acute kidney (AKI) in C57BL/6 (B6) and CD1-mice by longitudinal functional MRI-measurement of edema formation (T2-mapping) inflammation (diffusion weighted imaging (DWI)). IRI was induced with unilateral right renal pedicle clamping for 35min. 7T-MRI performed 1 14 days after surgery. DWI (7 b-values) multiecho TSE sequences TE) were acquired. Parameters quantified relation to the contralateral on day (d1). Renal MCP-1 IL-6-levels...
The aim of this study was the development and evaluation a real-time guidance support using optical Moiré Phase Tracking (MPT) for magnetic resonance (MR) guided percutaneous interventions. A gradient echo sequence, capable position updates by MPT system, modified to enable needle based on four rigidly attached markers at back needle. Two perpendicular imaging planes were automatically aligned along calibrated centered its tip. For user guidance, additional information about trajectory tip...
Purpose To implement and test variants of chemical shift imaging (CSI) acquiring both free induction decays (FIDs) showing all dissolved‐phase compartments spin echoes for specifically assessing Xe in lipids order to perform precise lipid‐dissolved MR thermometry a rat model general hypothermia. Methods Imaging was performed at 2.89 T. determined one by fitting exponentials decaying signals global spin‐echo spectra. Four rats (conventional CSI) six (turbo spectroscopic imaging) were scanned...
Abstract Background The purpose of our study was to describe and evaluate management, performance results Tuberculosis (TB)-screening among refugees asylum seekers in a rural area Germany 2015. Methods Refugees or seekers, staying shared-accommodation are obligated participate on screening chest X-ray (CXR) order screen for signs potentially infectious pulmonary TB (German Protection against Infection Act German Asylum Procedure Act). n = 705 individuals underwent detect September October...