Purpose To assess the feasibility of monitoring effects elexacaftor-tezacaftor-ivacaftor (ETI) therapy on lung ventilation and perfusion in people with cystic fibrosis (CF), using phase-resolved functional (PREFUL) MRI. Materials Methods This secondary analysis a multicenter prospective study was carried out between August 2020 March 2021 included participants 12 years or older CF who underwent PREFUL MRI, spirometry, sweat chloride test, clearance index assessment before 8–16 weeks after...

Purpose To test the feasibility of 3D phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and patients with chronic pulmonary disease, to compare 2D PREFUL, investigate required temporal resolution obtain stable PREFUL measurement. Methods Sixteen participants underwent using PREFUL. Retrospectively, spatial (4 × 4 mm 3 ) was decreased match 15 ), abbreviated as lowres . In addition regional ventilation (RVent), flow‐volume loops were computed rated by a cross‐correlation (CC)....

Phase-resolved functional lung MRI–derived parameters depicted pulmonary perfusion abnormalities in children and adolescents with post–COVID-19 condition correlated heart rate chronic fatigue severity.

Background Chronic lung allograft dysfunction (CLAD), the physiologic correlate of chronic rejection, remains a major barrier to long-term survival following transplant. Biomarkers for early prediction future transplant loss or death due CLAD might open window opportunity diagnosis and treatment CLAD. Purpose To evaluate prognostic use phase-resolved functional (PREFUL) MRI in predicting CLAD-related death. Materials Methods In this prospective, longitudinal, single-center study, PREFUL...

Background Non‐contrast‐enhanced 1 H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional ventilation but a comparison direct measurement using 19 F MRI is lacking. Purpose To compare parameters calculated 3D phase‐resolved functional (PREFUL) MRI. Study Type Prospective. Population Fifteen patients asthma, 14 chronic obstructive disease, and 13 healthy volunteers. Field Strength/Sequence A gradient‐echo pulse sequence golden‐angle increment...

Pulse wave velocity (PWV) in the pulmonary arteries (PA) is a marker of vascular stiffening. Currently, only phase-contrast (PC) MRI-based options exist to measure PA-PWV.

Background A previous study has demonstrated the feasibility of 3D phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and patients with chronic pulmonary disease. Before clinical use, repeatability ventilation parameters derived from PREFUL must be determined. Purpose To evaluate to compare testing (PFT). Study Type Prospective. Population Fifty‐three subjects 13 obstructive disease (COPD). Field Strength/Sequence prototype stack‐of‐stars spoiled‐gradient‐echo sequence at 1.5...

Contrast-free lung MRI based on Fourier decomposition is an attractive method to monitor various diseases. However, the accuracy of current perfusion quantification limited. In this study, a new approach for voxel-wise proton density and median signal decay toward steady state decomposition-based techniques proposed called QQuantified (QQuant ).Twenty patients with chronic obstructive pulmonary disease 18 thromboembolic hypertension received phase-resolved functional lung-MRI (PREFUL)...

Abstract Objectives 3D phase-resolved functional lung (PREFUL) MRI offers evaluation of pulmonary ventilation without inhalation contrast agent. This study seeks to compare maps obtained from PREFUL with a direct measurement derived 129 Xe in both patients chronic obstructive disease (COPD) and healthy volunteers. Methods Thirty-one COPD 12 controls underwent free-breathing breath-hold at 1.5 T. For techniques, defect (VD) were determined respective percentage (VDP) values computed. All...

Purpose The purpose of this study is to evaluate the influence different field strengths on perfusion and ventilation parameters, SNR CNR derived by PREFUL MRI using predefined sequence parameters. Methods Data sets free breathing 2d FLASH lung were acquired from 15 healthy subjects at 1.5T 3T (Magnetom Avanto Skyra, Siemens Healthcare, Erlangen, Germany) with a maximum period 3 days in between. processed functional parameters regional (RVent), (Q), quantified (Q Quant ), defect percentage...

Magnetic Resonance (MR) thermometry is used for the monitoring of MR-guided microwave ablations (MWA), and intraoperative evaluation ablation regions. Nevertheless, accuracy temperature mapping may be compromised by electromagnetic interference emanating from (MW) generator. This study evaluated different setups improving magnetic resonance imaging (MRI) during MWA with a modified MW was performed in 15 gel phantoms comparing three setups: The generator placed outside MR scanner room, either...

Introduction Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary condition that causes the formation of cysts primarily in kidneys. The continuous growth multiple leads to destruction functional parenchyma, which may progress end-stage disease. Tolvaptan only drug specifically approved for slowing down progression ADPKD. Sodium-glucose transporter 2 inhibitors might provide additional benefits but there currently no information on safety and outcome effects SGLT2i patients...

Abstract Purpose Surgical robotics have demonstrated their significance in assisting physicians during minimally invasive surgery. Especially, the integration of haptic and tactile feedback technologies can enhance surgeon’s performance overall patient outcomes. However, current state-of-the-art lacks such interaction opportunities, especially robotic-assisted interventional magnetic resonance imaging (iMRI), which is gaining importance clinical practice, specifically for percutaneous needle...

To share our experience using transurethral ultrasound ablation (TULSA) treatment for focal therapy of localized prostate cancer (PCa).Between 10/2019 and 06/2021 TULSA PCa was performed in 22 men (mean age: 67 ± 7 years, mean initial PSA: 6.8 2.1 ng/ml, ISUP 1 n = 6, 2 14 patients with recurrence after previous radiotherapy). Patients were selected by an interdisciplinary team, taking clinical parameters, histopathology from targeted or systematic biopsies, mpMRI preferences into...

Purpose To examine the time‐dependent diffusion of fluorinated ( 19 F) gas in human lungs for determination surface‐to‐volume ratio comparison to results from hyperpolarized 129 Xe and lung function testing healthy volunteers patients with chronic obstructive pulmonary disease. Methods Diffusion short‐time regime was measured using multiple gradient‐echo sequences a single pair trapezoidal gradient pulses. Pulmonary calculated first‐order approximation study 20 22 The repeatability after 7...

Purpose To evaluate the influence of intravenously administered gadolinium‐based contrast agents on functional ventilation and perfusion parameters derived by phase‐resolved lung (PREFUL) MRI. Methods Fourteen participants underwent MRI at 1.5T using a 2D spoiled gradient echo sequence during free breathing. Three data sets PREFUL images were obtained—the 1st set was acquired in mean 33:46 min (SD = 6:20 min) prior, 2nd 3rd 43 91 s (both SD 1.9 s), respectively, after i.v. application...

The purpose of this study is to evaluate the influences gadolinium-based contrast agents, field-strength and different sequences on perfusion quantification in Phase-Resolved Functional Lung (PREFUL) MRI.Four cohorts subjects were imaged analyze quantified maps: 1) at baseline after 2 weeks obtain reproducibility (26 COPD patients), 2) before administration gadobutrol (11 COPD, PAH 1 asthma), 3) 1.5T 3T (12 healthy, 4 CF), 4) with acquisition spoiled gradient echo (SPGR) balanced...

Rationale and ObjectivesFirst, to test the feasibility of cerebral blood flow (CBF) estimation using pulse wave amplitude in flow-related enhancement (FREE) brain MRI comparison pseudo-continuous arterial spin labeling (pCASL-MRI). Second, potential for acceleration was evaluated retrospectively.Materials Methods24 healthy study participants between 20 61 years had MRI. Perfusion imaging performed with a balanced steady-state free precession sequence FREE-MRI pCASL-MRI comparison.ResultsThe...

This paper challenges the traditional focus on individual 1on1 sessions during workflow simulations and usability testing, which often fail to capture collaborative nature of medical workflows. To overcome this, a human factors simulation lab was developed within research campus STIMULATE. The describes conception, development, operational capabilities particularly focusing assessment. A novel methodology, based hierarchical task analysis, is introduced. It breaks down complex workflows into...

Metronome-paced tachypnea (MPT) is a technique where patient breathes rapidly with fixed frequency (40 breaths / minute). MPT induces dynamic hyperinflation and allows investigation of potential stress-driven effects on ventilation parameters. Fifteen patients chronic obstructive pulmonary disease (COPD) thirty healthy subjects underwent MRI 2D coronal lung MR image acquired repeatedly temporal resolution 200 ms during resting tidal breathing (RTB) MPT. The decrease fractional (FV) the...

The aim of this study is the evaluation influences previously applied gadolinium-based contrast media, differing field strength and imaging sequence on lately proposed perfusion quantification for PREFUL MRI. results indicate severe alterations distortions quantified parameters after gadolinium administration depending type. show, that future multicenter studies need to strictly adhere an identical protocol using same strengths generate comparable across all sites.

Motivation: Flow-related enhancement (FREE)-MRI could be used to generate phase-resolved perfusion-weighted brain maps. Goal(s): To test cerebral blood flow (CBF) estimation using the pulse wave amplitude in FREE-MRI. Secondly, potential for acceleration was evaluated retrospectively. Approach: Twenty-four healthy subjects had MRI with balanced steady-state free precession imaging (FREE-MRI) and pCASL-MRI comparison. Results: The value distribution of estimated CBF showed disparity values...

Purpose Brain perfusion imaging is of enormous importance for various neurological diseases. Fast gradient-echo sequences offering flow-related enhancement (FREE) could present a basis to generate perfusion-weighted maps. In this study, we obtained maps without contrast media by previously described postprocessing algorithm from the field functional lung MRI. At first, signal was analyzed in fast low-angle shot (FLASH) and balanced steady-state free precession (bSSFP) sequences. Secondly,...