A5101897102- Food Quality and Safety Studies
- Agriculture, Soil, Plant Science
- Ecology and Conservation Studies
- Bacterial Genetics and Biotechnology
- DNA and Nucleic Acid Chemistry
- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- Marine Bivalve and Aquaculture Studies
- Bacteriophages and microbial interactions
- Identification and Quantification in Food
- Phytochemistry and Biological Activities
- RNA and protein synthesis mechanisms
- Phytochemistry and biological activity of medicinal plants
- Natural product bioactivities and synthesis
- Fecal contamination and water quality
- melanin and skin pigmentation
- GABA and Rice Research
- Fungal Biology and Applications
- Aquaculture Nutrition and Growth
- Plant biochemistry and biosynthesis
- RNA Research and Splicing
- Phytochemicals and Antioxidant Activities
- Medicinal Plants and Neuroprotection
- HIV/AIDS drug development and treatment
- Plant-derived Lignans Synthesis and Bioactivity
Seoul National University
1995-2024
Hallym University
2022-2024
National Institute of Fisheries Science
2001-2023
Korea University
2023
Kyung Hee University
2020-2022
University of Utah
2006-2021
Konkuk University Medical Center
2020
Korea Center for Disease Control and Prevention
2019
National Quarantine Station
2019
Korea Disease Control and Prevention Agency
2019
A number of recent reports have demonstrated that attenuated Salmonella typhimurium are capable targeting both primary and metastatic tumors. The use bacteria as a vehicle for the delivery anticancer drugs requires mechanism precisely regulates visualizes gene expression to ensure appropriate timing location drug production. To integrate these functions into bacteria, we used repressor-regulated tetracycline efflux system, in which therapeutic an imaging reporter were controlled by divergent...
Determining valid zygosity is a basic and important requirement in twin study, because misdiagnosing leads to biased results. The Healthy Twin Study has collected data from adult like-sex twins their families since 2005. In the questionnaire determine was developed comprising four questions; one concerning degree of resemblance, three confusion by resemblance. Among 2,761 individuals (624 pairs) families, 406 pairs (mean age 38.3, 63.5% women) with both genotype information were selected...
Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles within cells, with implications in various biological processes and disease states. AT-rich interactive domain-containing protein 1A (ARID1A) is a chromatin remodeling factor frequently associated cancer mutations, yet its functional mechanism remains largely unknown. Here, we find that ARID1A harbors prion-like domain (PrLD), which liquid condensates through PrLD-mediated LLPS. The nuclear formed by...
The present study describes the isolation from human urine and definitive chemical identification of 4 members a new class acidic metabolites corticol, characterized by 21-oic acid group: 3α, 17, 20α-trihydroxy-11-oxopregnan-21-oic acid; 3α,17,20β-trihydroxy-11-oxopregnan-21-oic 3α,11β,17,20α-tetrahydroxypregnan-21-oic 3α,11β,17,20β-tetrahydroxypregnan-21-oic trivial name “cortoic acids” is suggested for this group metabolites; individual compounds, named after corresponding 21-hydroxy...
The effect of superhelicity DNA templates on transcription is well documented in several cases. However, the amount supercoiling that needed to bring about any changes and steps at which such effects are exerted were not systematically studied. We investigated from a set promoters present plasmid by using series topoisomers with different superhelical densities ranging totally relaxed more than physiological. In vitro assays these absence presence gene regulatory proteins showed negative...
Abstract The present study aimed to investigate whether time-restricted feeding (TRF) ameliorates metabolic and reproductive phenotypes in a letrozole-induced mouse model of polycystic ovary syndrome (PCOS). Sixty female C57BL/6 N mice were randomly divided into two groups according the type food received: either chow or 60% high-fat diet. Those subcutaneously implanted with letrozole placebo pellets at four weeks age. Then, letrozole-treated assigned different regimens: (1) TRF for 4 h...
Isomerization of a closed to open complex promoter upon RNA polymerase binding involves base unpairing at the -10 region. After potassium permanganate sensitivity unpaired thymine residues, we studied region during isomerization P1 and P3 promoters gal operon. Substitution adenine by 2-amino purine (2-AP) invariable A small middle dotT pair -11 position prevented not only that but also other downstream positions, suggesting "master" role template strand in overall unpairing. 2-AP did inhibit...
Abstract The root of Platycodon grandiflorum (PG) has long been used as a traditional herbal medicine in Asian country. Platycondin D (PD), triterpenoid saponin that is main constituent PG, exhibits various biological activities such anti-inflammatory, anti-oxidant, anti-diabetic, and anti-cancer effects. A previous study showed PD had cholesterol-lowering effects mice develop hypercholesterolemia, but the underlying molecular mechanisms have not elucidated during last decade. Here, we...
The FliE component of the bacterial flagellum is first protein secreted through flagellar type III secretion system (fT3SS) that capable self-assembly into growing organelle. plays dual roles in assembly Salmonella as final and an adaptor anchors rod (drive shaft) motor to membrane-imbedded MS-ring structure.
ABSTRACT We have found, using a newly developed genetic method, protein (named Cnu, for oriC -binding nu cleoid-associated) that binds to specific 26-base-pair sequence cnb ) in the origin of replication Escherichia coli, . Cnu is composed 71 amino acids (8.4 kDa) and shows extensive acid identity group proteins belonging Hha/YmoA family. was previously discovered as that, like Hha, complexes with H-NS vitro. Our vivo vitro assays confirm results further suggest complex formation involved...
ABSTRACT Previous work suggested that the FlgE (flagellar hook subunit) protein in Salmonella enterica serovar Typhimurium was posttranscriptionally regulated response to stage of flagellar assembly. Specifically, could be detected mutants defective at stages assembly before or after rod but not mutants, yet flgE mRNA levels were unaffected. To elucidate posttranscriptional mechanisms involved coupling gene expression assembly, RNA sequences 5′ and 3′ ends -containing processed from large...
Schisandra chinensis Turcz. fruit is widely used to treat skin diseases. The aim of this study was determine the anti-inflammatory effects methanol extract S. (MESC) on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) in mice. MESC ear thickness and weight, histopathological changes, immune cell filtration cytokine production were investigated DNFB-induced CD Topical application effectively inhibited swelling (30 or 300 µg left ear, P<0.001; 30 right P<0.001). also...
From 2011 to 2013, we conducted a full sanitary survey of pollution sources in proximity shellfish growing area the Hansan-Geojeman region Korea, which includes designated area. In sea area, 1152 seawater and 209 oyster samples were collected examined evaluate their bacteriological quality. There 758 potential drainage including 40 discharging water 2013. Fecal coliform (FC) concentrations impact radii discharges ranged from 1.8 700,000 MPN/100 mL 3 600 m, respectively; however, pollutants...
Background: Adlay (Coix lacryma-jobi L. var. ma-yuen Stapf.) is an important medicinal and cereal crop that contains high levels of protein, fatty acids crude fiber, as well calcium, phosphorus, zinc, minerals, essential amino acids. Despite its economic significance, little known about biological activity in adlay sprouts. This study investigated the total free sugar, polyphenol flavonoid content, antioxidative sprouts at different growth stages.BR Methods Results: The sugar coixol content...