A5038938212- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- Supramolecular Self-Assembly in Materials
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Oral microbiology and periodontitis research
- Proteoglycans and glycosaminoglycans research
- Additive Manufacturing and 3D Printing Technologies
- Silk-based biomaterials and applications
- Advancements in Transdermal Drug Delivery
- Periodontal Regeneration and Treatments
- Intestinal and Peritoneal Adhesions
- Optical Coherence Tomography Applications
- Dermatologic Treatments and Research
- Ocular Surface and Contact Lens
- Proteins in Food Systems
- Microencapsulation and Drying Processes
- Surgical Sutures and Adhesives
- Connective tissue disorders research
- Polymer composites and self-healing
Daejeon Health Institute of Technology
2018
Pohang University of Science and Technology
2009-2016
Seoul National University
2010
The use of cell-rich hydrogels for three-dimensional (3D) cell culture has shown great potential a variety biomedical applications. However, the fabrication appropriate constructs been challenging. In this study, we describe 3D printing process preparation multilayered construct containing human mesenchymal stromal cells with hydrogel comprised atelocollagen and supramolecular hyaluronic acid (HA). This showed outstanding regenerative ability reconstruction an osteochondral tissue in knee...
A facile in situ supramolecular assembly and modular modification of biocompatible hydrogels were demonstrated using cucurbit[6]uril-conjugated hyaluronic acid (CB[6]-HA), diaminohexane-conjugated HA (DAH-HA), tags-CB[6] for cellular engineering applications. The strong selective host-guest interaction between CB[6] DAH made possible the CB[6]/DAH-HA presence cells. Then, 3D environment was modularly modified by simple treatment with various multifunctional tags-CB[6]. Furthermore, we could...
Despite a wide investigation of hydrogels as an artificial extracellular matrix, there are few scaffold systems for the facile spatiotemporal control mesenchymal stem cells (MSCs). Here, we report 3D tissue engineered supramolecular prepared with highly water-soluble monofunctionalized cucurbit[6]uril–hyaluronic acid (CB[6]-HA), diaminohexane conjugated HA (DAH-HA), and drug CB[6] (drug-CB[6]) controlled chondrogenesis human (hMSCs). The mechanical property was modulated by changing...
A novel, biocompatible, and nontoxic dermal filler using hyaluronic acid (HA) hydrogels was successfully developed for tissue augmentation applications. Instead of highly reactive cross-linkers such as divinyl sulfone (DVS) Hylaform, 1,4-butanediol diglycidyl ether (BDDE) Restylane, 1,2,7,8-diepoxyoctane (DEO) Puragen, HA were prepared by direct amide bond formation between the carboxyl groups hexamethylenediamine (HMDA) with an optimized group modification effective augmentation. The...
ZnO nanoflowers prepared by a solution-based hydrothermal growth method result in effective osteoblast with higher DNA content, ALP activity, and adhesion strength than those on film. Furthermore, are tightly osseointegrated into the regenerated bones. The approach for fabricating nanoflower structures biomaterial surfaces can be successfully exploited various bone tissue engineering applications.
Abstract Despite wide applications of bone morphogenetic protein–2 (BMP‐2), there are few methods to incorporate BPM‐2 within polymeric scaffolds while maintaining biological activity. Solid free‐form fabrication (SFF) tissue‐engineering scaffold is successfully carried out with poly(lactic‐ co ‐glycolic acid) grafted hyaluronic acid (HA‐PLGA) encapsulating intact BMP‐2/poly(ethylene glycol) (PEG) complex. HA‐PLGA conjugate synthesized in dimethyl sulfoxide (DMSO) by the conjugation reaction...
Synthetic hydrogels have been extensively investigated as artificial extracellular matrices (ECMs) for tissue engineering in vitro and vivo. Crucial challenges such are sustaining long‐term cytocompatible encapsulation providing appropriate cues at the right place time spatio‐temporal control of cells. Here, situ supramolecularly assembled modularly modified engineered mesenchymal stem cell (eMSC) therapy reported using cucurbit[6]uril‐conjugated hyaluronic acid (CB[6]‐HA), diaminohexane...
Without exploitation of possibly immunogenic and carcinogenic bone morphogenetic protein, we developed simple but clinically feasible artificial graft using osteoconductive hyaluronate (HA) hydrogels bioactive MegaGen synthetic (MGSB).HA were synthesized by the crosslinking reaction between carboxyl groups HA amine gelatin (GEL). Then, grafts prepared mixing MGSB with HA-GEL hydrogels. The regeneration MGSB/HA-GEL hydrogel complex was assessed in skull New Zealand white male rabbits 4 8...
Microcapsules are employed extensively in various applications; however, most composed of synthetic plastics. Thus, substitution their component materials is essential to prevent environmental problems associated with primary microplastics. Herein, we report the synthesis eco-friendly silica core–shell microcapsules for fragrance retention. The shell was prepared via oil/water emulsion template using tetraethyl orthosilicate (TEOS), which added immature prior complete formation shells...
Abstract The temperature‐responsive poly(N‐isopropylacrylamide) [PNIPAAm] has been exploited for various biomedical applications. In this work, poly(N‐isopropylacrylamide‐ co ‐dopamine methacrylamide) [P(NIPAAm‐ ‐DMAAm)] was synthesized facile surface modification and application to cell sheets. 1 H NMR, FT‐IR, GPC confirmed the successful synthesis of P(NIPAAm‐ ‐DMAAm). lower critical solution temperature measured be ca. 29.2 °C by UV–Vis spectroscopy. AFM imaging clearly visualized...
Synchrotron X-ray bioimaging was successfully carried out to observe bone regeneration by a novel artificial substitute of bioactive MegaGen Synthetic Bone (MGSB) and hyaluronate (HA) hydrogels. A biphasic calcium phosphate MGSB prepared chemical precipitation method, with porous spherical morphology. On the basis fact that HA plays important roles in promotes differentiation, vascularization, migration stem cells, HA-cystamine (CYS) hydrogels cleavable disulfide linkages were supply...
Abstract Background The interaction between light and the skin determine how looks to human eye. Light can be absorbed, scattered, reflected by different components of in a variety ways. Here, we focus on scattering properties outmost layer, stratum corneum (SC). However, currently have limited methods with which distinguish SC from changes due other skin. Materials Dark‐field images tape‐striped corneocytes were used vitro study differences scattered components. Several optical clearing...
We present a simple and highly versatile protocol for polymer ablation: hard x-ray irradiation makes it possible to rapidly depolymerize hyaluronan hydrogels fabricate three-dimensional network of microchannels. Photodynamic photochemical analyses show that directly cleaves the backbone total dose controls degradation kinetics. This nonthermal ablation may offer opportunities processing organic polymers biological materials.
Microcapsules are widely utilized in various applications to preserve active ingredients for prolonged durations while enabling controlled release. However, limited release of often hampers their effectiveness daily-use products. In this study, we demonstrated the synthesis silica core–shell microcapsules designed fragrance topical formulations. The were synthesized via sol–gel polymerization tetraethyl orthosilicate (TEOS) on surface an oil/water emulsion, leveraging shrinkage and...
Front Cover: AFM of poly(N-isopropylacrylamide-co-dopamine methacrylamide) [P(NIPAAm-co-DMAAm)], with catechol groups for facile surface modification, clearly visualized the temperature-responsive transient phase transition. In addition, adhesive and P(NIPAAm-co-DMAAm) was successfully exploited preparation fibroblast cell sheets. Further details can be found in article by J. K. Park, S. Kim, Yeom, H. Jung, Hahn* on page 2130.
A novel artificial bone substitute composed of bioactive MegaGen synthetic (MGSB) and hyaluronate (HA) hydrogels was successfully developed for tissue engineering applications. HA is known to play important roles in regeneration due its angiogenic osteoconductive characteristics. Accordingly, hydrogel designed supply continuously effective by controlled degrada- tion vivo. Synchrotron X-ray bio-imaging clearly visualized 3-dimensional micron scale morphologies effectively regenerated bones...
K. Kim, Y. C. Sung, S. Hahn, and co-workers develop supramolecular hydrogels for long-term engineered mesenchymal stem cell (eMSC) therapy using the host-guest chemistry of cucurbit[6]uril diaminohexane on page 237. The eMSCs can produce enhanced green fluorescence protein within in mice more than 60 days. This platform technology is successfully applied to treatment cancer, reflecting feasibility various tissue engineering.