A5040386543- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Diamond and Carbon-based Materials Research
- Adenosine and Purinergic Signaling
- Botulinum Toxin and Related Neurological Disorders
- Force Microscopy Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Lubricants and Their Additives
- Ion channel regulation and function
- Genetics and Neurodevelopmental Disorders
- Peptidase Inhibition and Analysis
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
Institute for Basic Science
2025
Korea Advanced Institute of Science and Technology
2006-2017
Korea Institute of Science and Technology
2002-2007
Zero to Three
2007
Although T-type Ca(2+) channels are implicated in nociception, the function of specific subtypes has not been well defined. Here, we compared pain susceptibility mice lacking Ca(V)3.2 subtype (Ca(V)3.2(-/-)) with wild-type littermates various behavioral models to explore roles processing noxious stimuli vivo. In acute mechanical, thermal and chemical tests, Ca(V)3.2(-/-) showed decreased responses mice. also displayed attenuated tonic such as intraperitoneal injections irritant agents...
Pharmacological suppression of γ-aminobutyric acid (GABA) transaminase (GABA-T), the sole GABA-degrading enzyme and a potential therapeutic target for treating brain disorders such as epilepsy, increases not only phasic inhibition but also tonic inhibition. However, specific cellular source, neuromodulatory effects benefits this enhanced remain unexplored due to lack cell-type-specific gene manipulation studies. Here we report that increase in GABA currents observed after GABA-T is...
Abnormal phospholipid metabolism has been implicated in the pathogenesis of schizophrenia, and it was reported that phospholipase C (PLC) β1 is reduced specific brain areas patients with schizophrenia. However, causal relationship PLCβ1 gene behavioral symptoms schizophrenia remains unclear. To address this issue, we have examined mutant mice lacking for schizophrenia‐related phenotypes by performing various tests, including general locomotor activity, sensorimotor gating, social behaviors,...
Novelty stimuli cause various behavioral responses, such as exploration and avoidance, contextual variables may contribute to the outputs. Here, we tried compare responses novel objects of five inbred strains mice (C57BL/6J, 129/svJae, C3H/HeJ, BALB/cJ DBA/2J) by using a modified object test where small light‐weight cube wrapped with paper was presented in home cage without beddings. In response these objects, C57BL/6J, 129/svJae C3H/HeJ showed mild exploratory behaviors, approaching,...
Metabolic diseases affect various organs including the brain. Accumulation or depletion of substrates frequently leads to brain injury and dysfunction. Deficiency aminopeptidase P1, a cytosolic proline‐specific peptidase encoded by Xpnpep1 gene, causes an inborn error metabolism (IEM) characterized peptiduria in humans. We previously reported that knockout P1 mice neurodevelopmental disorders peptiduria. However, little is known about pathophysiological role Here, we show loss behavioral...
The molecular design of surface structures with built-in mechanisms for mechanical energy dissipation under nanomechanical deformation and compression resistance provided superior nanoscale wear stability. We designed robust, well-defined trilayer nanostructures chemically grafted to a silicon oxide an effective composite modulus about 1 GPa. total thickness was within 20–30 nm included 8 rubber layer sandwiched between two hard layers. provides mechanism dissipation, facilitated by...