A5101644907- Cancer-related gene regulation
- High Altitude and Hypoxia
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular and Diving-Related Complications
- Plant nutrient uptake and metabolism
- Adipose Tissue and Metabolism
- Neurological diseases and metabolism
- Genetic Associations and Epidemiology
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- Reproductive System and Pregnancy
- Protease and Inhibitor Mechanisms
- Microscopic Colitis
- S100 Proteins and Annexins
- Health Systems, Economic Evaluations, Quality of Life
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Autism Spectrum Disorder Research
- Phosphorus and nutrient management
- Immune cells in cancer
- Seismic Waves and Analysis
- Genital Health and Disease
- Inflammasome and immune disorders
Southwest University
2022-2025
Case Western Reserve University
2023-2025
Harbin University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Guangzhou University of Chinese Medicine
2021-2023
Zhongshan Hospital
2022
Guangdong Ocean University
2022
Fudan University
2022
China West Normal University
2022
Guizhou Cancer Hospital
2019
Pain is a common and complex non-motor symptom in people with Parkinson's disease (PWP). Little known about the genetic drivers of pain PWP, progress its study has been challenging. Here, we conducted two genome-wide association studies (GWAS) to identify variants associated experienced during earliest stages disease. The population consisted 4,159 PWP European ancestry who were mapped five previously-described, longitudinal trajectories. In first GWAS, extreme trajectories (highest burden...
Phosphorus (P) is an essential macronutrient for Brassica napus L. growth and development, mainly acquired from the soil as phosphate (Pi). However, there no research on system analysis of Pi utilization related genes (PURs) in B. yet. In this study, 285 PURs were identified genome, including 4 transcription factor (TF) gene families (83 genes) 17 structural (202 genes). Subcellular localization showed that proteins encoded by located nucleus (~ 46.0%) cell membrane 36.5%). Chromosome...
Abstract Background This study was aimed to evaluate the involvement of lncRNA MALAT1 in modifying chemo‐sensitivity laryngeal squamous cell carcinoma (LSCC) lines. Methods Totally 108 pairs tumor tissues and matched para‐tumor normal were gathered from patients who pathologically confirmed as LSCC. Meanwhile, LSCC lines, including TU686, TU177, AMC‐HN‐8, LSC‐1, purchased their tolerance cisplatin, 5‐fluorouracil, paclitaxel, vincristine. Additionally, CCK‐8 assay, flow cytometry, transwell...
Low-molecular-weight oyster peptides (LOPs) are typical bioactive with ameliorated immunomodulatory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along cytotoxic to establish model investigate ameliorative effects of LOPs function structure. Our results showed that administration alleviated weight loss, reduced spleen tissue damage, increased splenic...
To study associations between type 2 diabetes (T2DM) candidate genes and microvascular complications of (MVCDs), we performed case-control association studies for both T2DM MVCDs in Han Chinese subjects. We recruited 1,939 unrelated patients 918 individuals with normal blood glucose levels as nondiabetic controls. Among patients, 1116 have MVCDs, 266 a history >10 years but never developed MVCDs. Eighty-two single-nucleotide polymorphisms (SNPs) 54 were genotyped. Discrete by the PLINK...
Abstract We have described two novel implantation serine proteinase ( ISP ) genes that are expressed during the period. The ISP1 gene may encode embryo‐derived enzyme strypsin, which is necessary for blastocyst hatching in vitro and initiation of invasion. ISP2 gene, encodes a related tryptase, endometrial glands regulated by progesterone peri‐implantation Based on similarities between expression progesterone‐regulated lumenal activity associated with lysis zona pellucida, we suggested...
Cardiovascular function and adipose metabolism were markedly influenced under high altitudes. However, the interplay between adipokines heart hypoxia remains to be elucidated. We aim explore alterations of underlying mechanisms in regulating cardiac investigated cardiopulmonary five Antarctic expeditioners at Kunlun Station (4,087 m) for 20 days established rats exposed hypobaric (5,000 m), simulating Station. exhibited elevated rate, blood pressure, systemic vascular resistance, decreased...
Objectives For Crohn’s disease (CD), the alternation of active phase and inactive may be related to humoral immunity cellular immunity. This study aims understand characteristics immune cells in patients with CD (CDa) (CDin). Methods Mass cytometry (CyTOF) single-cell RNA sequencing (scRNA-seq) data about CDa, CDin, healthy control (HC) were included. CyTOF analysis was performed capture gated subsets, including T cells, regulatory (Treg) B innate natural killer (NK) cells. Differential used...
Background: The pathogenesis of ulcerative colitis (UC) is closely related to immunity. immune characteristic differences between active UC (UCa) and inactive (UCin) have not been completely explained. Mass cytometry (CyTOF) single-cell RNA sequencing (scRNA-seq) were used analyze the cells UCa, UCin healthy control (HC) subjects determine specific characteristics. Methods: cell subsets among UCin, HC distinguished using CyTOF analysis. scRNA-seq analysis was validate results CyTOF. Gene...
Abstract During implantation, a balance of factors regulates the invasive properties embryo and anti‐invasive uterine decidua. Although antiproteinases such as metalloproteinase inhibitor TIMP‐3 are thought to play critical roles in preventing overaggressive invasion trophoblasts, mechanism antiproteinase regulation is unknown. Recently, prohormone convertase SPC‐6 has been found be co‐expressed embryo‐proximal decidua association with TIMP‐3. As members this serine proteinase family known...
<title>Abstract</title> <bold>Background: </bold>Phosphorus (P) is an essential macronutrient for <italic>Brassica napus</italic> L. growth and development, mainly acquired from the soil as phosphate (Pi). However, there no research on system analysis of Pi utilization related genes (<italic>PURs</italic>) in <italic>B. yet. <bold>Results</bold>: In this study, 285 <italic>PURs</italic> were identified genome, including 4 transcription factor (TF) families (83 genes) 17 structural gene (202...
Several studies have reported the detrimental impacts of hypoxia exposure on sleep. Chinese Kunlun Station (altitude 4087 m) is located at Dome A, highest point Antarctic ice sheet and one most extreme environments Earth. This study investigated alteration sleep, breathing mood status in healthy expeditioners A. The examined 10 male volunteers inland transverse party to during 31st National Research Expedition, valid data from eight were analyzed. Sleep structure, pattern monitored using...
Summary Multimodal dispersion curves characterize the Rayleigh waves in layered azimuthally anisotropic medium. Hi-modes of wave are more sensitive to model anisotropy than fundamental mode. Numerical simulations conducted for three earth structures; results show that level data varies with azimuthal angles and arrival largest at angle 45°.
<h3>Objective:</h3> To conduct the first genome-wide association study (GWAS) of pain in persons with Parkinson's disease (PWP). <h3>Background:</h3> Pain is a common and complex non-motor symptom experienced by ~60% PWP. Little known about genetic non-genetic determinants <h3>Design/Methods:</h3> Using data spanning ~4.5 years from 8,612 PWP who are early their course (<3 years), available through Fox Insight Data Exploration Network, we empirically discerned 5 subgroups similar...
Polygenic risk scores (PRS) based on genome-wide discoveries are promising predictors or classifiers of disease development, severity, and/or progression for common clinical outcomes. A major limitation most is the paucity in diverse populations, prompting an emphasis to generate these needed data trans-population and population-specific PRS construction. Given just now being completed, there has been little opportunity be evaluated populations independent from discovery efforts. To fill...