A5102795267- Heme Oxygenase-1 and Carbon Monoxide
- Acupuncture Treatment Research Studies
- Thermal Regulation in Medicine
- Eicosanoids and Hypertension Pharmacology
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Healthcare and Venom Research
- Vagus Nerve Stimulation Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Hydrogen's biological and therapeutic effects
- High Altitude and Hypoxia
- Medical Research and Treatments
- Surgical Sutures and Adhesives
- Advanced Chemical Sensor Technologies
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- ATP Synthase and ATPases Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Sphingolipid Metabolism and Signaling
Xi'an Jiaotong University
2023-2025
Tianjin Nankai Hospital
2014-2023
Tianjin Medical University
2013-2023
Xi'an Technological University
2022
Research Institute of Petroleum Exploration and Development
2020
Tianjin Hospital
2020
Novem (Netherlands)
2016
Guangzhou Medical University
2016
Sepsis-associated acute lung injury remains the major cause of mortality in critically ill patients and is characterized by marked oxidative stress mitochondrial dysfunction. Mitochondrial dynamics are indispensable for functional integrity. Additionally, heme oxygenase (HO)-1/carbon monoxide conferred cytoprotection against end-organ damage during endotoxic shock. Herein, we tested hypothesis that HO-1/carbon played a critical role maintaining dynamic process fusion/fission to mitigate...
NF-E2 related factor 2 (Nrf2) is a major transcription and acts as key regulator of antioxidant genes to exogenous stimulations. The aim current study was determine whether Nrf2/ARE pathway involved in the protective effect electroacupuncture on injured lung rabbit model endotoxic shock. A dose lipopolysaccharide (LPS) 5 mg/kg administered intravenously replicate acute injury induced by Electroacupuncture pretreatment handled bilaterally at Zusanli Feishu acupoints for five consecutive days...
Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common and important oxidative stress in the lung. Mitochondrial fusion responds to normal morphology function of cells finely regulated by mitochondrial proteins, such as mitofusin-1 protein (Mfn1), mitofusin-2 (Mfn2) optical atrophy 1 (OPA1). Additionally, Mfn1 has been identified most fusion. Heme oxygenase-1 (HO-1) stress-inducible that plays critical role protecting against stress. However, whether...
Sepsis-induced acute lung injury (ALI) is a severe condition with limited effective therapeutics; nicotinamide mononucleotide (NMN) has been reported to exert anti-inflammatory activities.This study explores the potential mechanisms by which NMN ameliorates sepsis-induced ALI in vivo and vitro.Cultured MH-S cells murine model were used evaluate effect of on ALI. stimulated LPS (1 μg/mL) (500 μM) for 12 h grouping as control, LPS, + NMN. Cell viability, apoptotic status, M1/2...
Pulmonary microvascular endothelial cells (PMVECs) are notably implicated in the pathogenesis of sepsis-induced lung injury. Exosomes derived from PMVECs facilitate intercellular communication among various cell types, especially crosstalk with macrophages. Heme oxygenase-1 (HO-1), an early stress-responsive enzyme inherent protective functions, has been acute injury (ALI) mitigation. But research on mechanism HO-1 macrophage polarization via PMVEC exosomes is lacking. To investigate role...
Electroacupuncture at select acupoints have been verified to protect against organ dysfunctions during endotoxic shock. And, heme oxygenase (HO)-1 as a phase II enzyme and antioxidant contributed the protection of kidney in septic shock rats. The phosphatidylinositol 3-kinase (PI3K)-Akt pathway mediated activation NF-E2 related factor-2 (Nrf2), which was involved HO-1 induction. To understand efficacy electroacupuncture stimulation ameliorating acute injury (AKI) through PI3K/Akt/Nrf2...
Heme oxygenase (HO)-1 has been reported to play a great role in attenuating lung injury during endotoxic shock our previous research. Although electro-acupuncture explored reduce oxidative stress and decrease inflammatory reaction animals with shock, the mechanism of this effect is still unclear. The aim study was determine whether HO-1 involved on injured rabbits. Sixty New England white rabbits were randomly divided into groups C, Z, ES, EA, AP, EAZ. Before inducing group ES received no...
In this paper, the influence of external terahertz electromagnetic fields with different frequencies 4 THz, 10 15 and 20 THz on permeability Kv1.2 voltage-gated potassium ion channel nerve cell membrane was studied using combined model “Constant Electric Field-Ion Imbalance” method by molecular dynamics. We found that although applied electric field does not produce strong resonance –C=O groups conservative sequence T-V-G-Y-G amino acid residue selective filter (SF) channel, it would affect...
Sepsis-related acute respiratory distress syndrome is characterized by marked oxidative stress and mitochondrial dysfunction lacking of specific therapy. Heme oxygenase (HO)-1 followed endogenous carbon monoxide (CO) exerted a cytoprotective effect against multi-organ damage during sepsis. Additionally, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway, which serves as an upstream regulator HO-1, was associated with inflammation stress. Therefore, purpose present study...
Abstract Background After surgery, millions of people suffer from delayed healing or wound dehiscence with subsequent severe complications, even death. Previous studies have reported that ropivacaine exhibits anti-proliferative and anti-migratory activities on numerous cells. Whether is able to influence the proliferation migration keratinocytes still unclear. This study aimed investigate effect its underlying molecular mechanism. Methods Adult male Sprague–Dawley rats were allocated...
Mitochondrial function and morphology are dynamically regulated by fusion fission. Heme oxygenase-1 (HO-1), which may be upregulated protein kinase C-α (PKC-α), improves mitochondrial dynamics controlling the balance between fission in vivo vitro. However, whether PKC-α/HO-1 signaling pathway is one of underlying mechanisms adjusting lipopolysaccharide (LPS)-activated macrophages has remained elusive. To explore this, NR8383 cells were pre-treated with PKC-α inhibitor Go6976 or activator...