A5065349005- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Nanoplatforms for cancer theranostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- High Altitude and Hypoxia
- Liver Disease Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Cell Adhesion Molecules Research
- Cardiac Ischemia and Reperfusion
- Nanoparticle-Based Drug Delivery
- Eicosanoids and Hypertension Pharmacology
- Minerals Flotation and Separation Techniques
- Cerebrovascular and Carotid Artery Diseases
- Gut microbiota and health
- Pregnancy and preeclampsia studies
- Cardiovascular Health and Disease Prevention
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- Fatty Acid Research and Health
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Atrial Fibrillation Management and Outcomes
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
Tianjin Medical University
2018-2024
Inner Mongolia Electric Power (China)
2024
Tibet Autonomous Region People's Hospital
2018-2024
Army Medical University
2024
Xinqiao Hospital
2024
Air Force Medical University
2014-2023
Anhui University
2023
Chongqing Medical University
2023
Imperial College London
2021
The University of Texas at Arlington
2020
Myocardial ischemia-reperfusion (I/R) injury causes cardiac dysfunction to myocardial cell loss and fibrosis. Prevention of death is important protect function after I/R injury. The process reperfusion can lead multiple types cardiomyocyte death, including necrosis, apoptosis, autophagy, ferroptosis. However, the time point at which various modes occur mechanisms underlying ferroptosis regulation in cardiomyocytes are still unclear.Using a left anterior descending coronary artery ligation...
Evidence suggests that various forms of α -synuclein- ( Syn-) mediated microglial activation are associated with the progression Parkinson’s disease. MicroRNA-155-5p (miR155-5p) is one most important microRNAs and enables a robust inflammatory response. Triptolide (T10) natural anti-inflammatory component, isolated from traditional Chinese herb. The objective current study was to identify role potential regulatory mechanism T10 in Syn-induced via miR155-5p SHIP1 signaling pathway. Mouse...
Rationale: Timely inhibition of inflammation and initiation resolution are important to repair injured tissues. MST1/2 (mammalian STE20-like protein kinase 1/2) acts as a regulator macrophage-associated immune responses bacterial infections. However, the role in regulating macrophage phenotype function myocardial infarction (MI) remains unclear. Objective: To determine underlying mechanism cardiac post-MI. Methods Results: Using LysMCre -mediated Mst1/2 -deficient mice, we found that MST1...
Nanobubbles (NBs) combined with ultrasound-targeted destruction (UTD) have become promising potential carriers for drug or siRNA delivery. Due to their nano-size, NBs could penetrate tumor blood vessels and accumulate in intercellular spaces so that "sonoporation" induced by UTD would act directly on the cells increase cell membrane permeability.Based successful fabrication of NBs, we synthesized carrying (NBs-siRNA) using a biotin-streptavidin system. We then utilized ultrasound irradiation...
Hepatic steatosis is the beginning phase of nonalcoholic fatty liver disease, and hyperhomocysteinemia (HHcy) a significant risk factor. Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) other epoxy acids, attenuating their cardiovascular protective effects. However, involvement sEH in HHcy-induced hepatic unknown. The current study aimed to explore role lipid disorder. We fed 6-wk-old male mice chow diet or 2% (wt/wt) high-metnionine for 8 wk establish HHcy model....
Abstract Fluorescence imaging is a remarkable tool for molecular targeting and multicolor imaging, but it suffers from low resolution in centimeter‐deep tissues. The recently developed ultrasound‐switchable fluorescence (USF) has overcome this challenge achieved vivo mouse with help the indocyanine green (ICG) dye encapsulated poly(N‐isopropylacrylamide) (ICG‐PNIPAM) contrast agent. However, ICG‐PNIPAM shortcomings, such as concerns about cytotoxicity blueshifted excitation emission spectra....
Pancreatic cancer will gradually become the second leading cause of death due to its poor suitability for surgical treatment, frequent recurrence and metastasis, insensitivity radiotherapy chemotherapy. Strategies precise early detection effective targeted treatment pancreatic are urgently needed. Because unique advantages, molecular contrast-enhanced ultrasound imaging (CEUI) has generated new opportunities overcome this challenge. The aim study was explore multifunctional nanobubbles named...
Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis a pathological hallmark of structural remodeling in AF. Prostaglandin I
Abstract Pre‐eclampsia ( PE ) is considered a leading cause of mortality and morbidity in pregnant women worldwide. Eicosanoids derived from polyunsaturated fatty acids PUFA s) might play an important role the occurrence development . Omega‐3 s are nutrients that popular supplements for can reduce blood pressure. However, levels eicosanoids omega‐3 with not clear. The purpose this study was to investigate eicosanoid metabolic signature We performed case–control using data (n = 10)...
Background and Purpose The increased proliferation migration of vascular smooth muscle cells (VSMCs) after arterial injury contributes greatly to the pathogenesis neointimal hyperplasia. As a major component epigenetics, histone methylation plays an important role in several cardiovascular diseases. However, its restenosis is still unclear. Experimental Approach Human aortic VSMCs were challenged with PDGF‐BB, total histones extracted analysed by HPLC/MS. For vivo study, rats subjected...
Currently, effective detection and treatment of cutaneous malignant melanoma (CMM) still face severe challenges. Ultrasound molecular imaging as a noninvasive easy-to-operate method is expected to bring improvements for tumor detection.The aim this research prepare novel phase-change ultrasound contrast agents, Nds-IR780, which can perform not only dual-mode molecule-targeted but also targeted photothermal therapy CMM.A double emulsion process was used the Nds-IR780. Then, entrapment rate...
Introduction Myocardial infarction (MI) is a fatal manifestation of coronary heart disease, and its underlying mechanism still largely unknown. Lipid levels composition alterations predict the risk MI complications. Glycerophospholipids (GPLs) are important bioactive lipids play crucial role in development cardiovascular diseases. However, metabolic changes GPLs profile during post-MI injury remain Methods In current study, we constructed classic model by ligating left anterior descending...
Diabetic retinopathy (DR) is increasingly becoming a main complication of diabetes, and difficult to cure. In our research, network pharmacology analysis suggested that both compound Danshen dripping pills (CDDP) bezafibrate (BZF) have potential protective effects against DR the two drugs may act synergistically. The pharmacological coadministration CDDP BZF were elucidated in db/db mice, which simulate DR. Fluorescein fundus angiography showed attenuated vascular leakage. Optical coherence...
Individuals residing in plateau regions are susceptible to pulmonary hypertension (PH) and there is an urgent need for a prediction nomogram assess the risk of PH this population. A total 6603 subjects were randomly divided into derivation set validation at ratio 7:3. Optimal predictive features identified through least absolute shrinkage selection operator regression technique, nomograms constructed using multivariate logistic regression. The performance these was evaluated validated area...
The purpose of this study was to prepare tumor-specific dual-mode nanobubbles as both ultrasound contrast agents (UCAs) and near-infrared fluorescence (NIRF) imaging for female tumors. Recent studies have demonstrated the conjugation anti-tumor ligands on surface use molecule-targeting tumor visualization. However, complicated procedure has also posed a challenge nanobubble stability. Thus, in present study, we combined fluorescent dye, NIRF IR-780 iodide, which lipid solubility...
Nanobubble is an innovative ultrasound contrast agent that triggers the development of targeted imaging HER2-positive breast cancer by combining with HER2 affibody and IR783. HPPH a second-generation photosensitiser effective in treating tumours. Hence, nanobubble-IR783-HPPH-affibody (NIHA) complex demonstrates considerable potential treatment cancer.We fabricated NIHA via advanced thin-film hydration method detected its characteristics such as particle size, morphology, stability,...
Abstract Glycerophospholipids (GPs) and sphingolipids (SPs) are important lipid components in the body play biological functions. Omega‐3 polyunsaturated fatty acids (n‐3 PUFAs) nutrients, their supplements commonly used for preventing some diseases. However, effect of n‐3 PUFAs on human glycerophospholipidome sphingolipidome is unclear. We targeted lipidomics to study GP SP profile healthy individuals after supplementation with 3, 7, 14 21 days. Fuzzy c‐means clustering was cluster species...
Nanobubble (NB), a newly developed nanoscaled ultrasound contrast agent (UCA) for molecular imaging, has been widely researched these years. Targeting it with functional molecule, nanobubble can adhere selectively to cellular epitopes and receptors outside the vasculature via enhanced permeability retention (EPR) effect of tumor blood vessel. To enhance targeting rate our previous prepared NBs-Affibody HER2 (+) breast cancer we introduced near-infrared fluorescent (NIRF) dye, IR783, in this...