A5073903735- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Optical Imaging and Spectroscopy Techniques
- Ultrasound and Hyperthermia Applications
- Coffee research and impacts
- Biodiesel Production and Applications
- Photosynthetic Processes and Mechanisms
- Regulation of Appetite and Obesity
- Dermatological and Skeletal Disorders
- Advanced Battery Technologies Research
- Peroxisome Proliferator-Activated Receptors
- Porphyrin and Phthalocyanine Chemistry
- Electrochemical Analysis and Applications
- Adipose Tissue and Metabolism
The University of Texas Southwestern Medical Center
2015-2022
The University of Texas at Arlington
2018-2022
Nanjing University
2021
Nanjing General Hospital of Nanjing Military Command
2021
Optica
2018
Virginia Commonwealth University
2018
University of Cincinnati
2017
Tongji Hospital
2015
Huazhong University of Science and Technology
2015
Abstract Fluorescence imaging is a remarkable tool for molecular targeting and multicolor imaging, but it suffers from low resolution in centimeter‐deep tissues. The recently developed ultrasound‐switchable fluorescence (USF) has overcome this challenge achieved vivo mouse with help the indocyanine green (ICG) dye encapsulated poly(N‐isopropylacrylamide) (ICG‐PNIPAM) contrast agent. However, ICG‐PNIPAM shortcomings, such as concerns about cytotoxicity blueshifted excitation emission spectra....
The conventional fluorescence imaging has limited spatial resolution in centimeter-deep tissue because of the tissue's high scattering property. Ultrasound-switchable (USF) imaging, a new technique, was recently proposed to realize high-resolution tissue. However, vivo USF not been achieved so far lack stable near-infrared contrast agents biological environment and data about their biodistributions. In this study, for first time, we successfully mice with resolution. porcine heart mouse...
Ultrasound-switchable fluorescence (USF) is a novel imaging technique that provides high spatial resolution images in centimeter-deep biological tissue. Recently, we successfully demonstrated the feasibility of vivo USF using frequency-domain photomultiplier tube-based system. In this work, for first time carried out via camera-based The system acquires signal on two-dimensional (2D) plane, which facilitates image acquisition because scanning area can be planned based 2D and photon...
The ultrasound-switchable fluorescence (USF) technique was recently developed to achieve high-resolution imaging in centimeters-deep tissue. This study introduced strategies significantly improve sensitivity and depth using an electron multiplying charge-coupled device (EMCCD) camera-based USF system a newly contrast agent of indocyanine green (ICG)-encapsulated liposomes. For quantitative study, phantom sub-millimeter silicone tube embedded centimeter-thick chicken breast tissue adopted...
The spatial resolution of the conventional fluorescence imaging in centimeter-deep tissue is limited due to high light scattering. Ultrasound-switchable (USF) was recently developed achieve deep tissue. However, previous frequency-domain USF systems adopted a fiber bundle collect emitted photons, which led few limitations, such as, first, low photon-collection efficiency; second, efficiency for scanning sample with an uneven surface; third, speed, because adoption raster scan and long wait...
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that was originally identified as regulator of peroxisome proliferation and adipocyte differentiation. Emerging evidence suggests functional PPARγ signaling also occurs within the hypothalamus. However, exact distribution identities PPARγ-expressing hypothalamic cells remains under debate. The present study systematically mapped mRNA expression in adult mouse brain using situ hybridization...
Liposomes have been widely used in both medical imaging and drug delivery fields due to their excellent biocompatibility easy surface modification. Recently our lab reported for the first-time implementation of temperature-sensitive indocyanine green (ICG)-encapsulated liposome microparticles vivo ultrasound-switchable fluorescence (USF) imaging. A previous study showed that achieved USF centimeter-deep tissue. This aimed control size liposomes at nanoscale effect on depth. Also, we explored...
Ultrasound-switchable fluorescence (USF) imaging was recently developed to overcome the limitation of poor spatial resolution conventional in centimeter-deep tissue. However, vivo USF has not been achieved so far because lack stable near-infrared contrast agents a biological environment and data about their biodistributions. In this study, for first time, we successfully mice with high resolution. porcine heart tissue mouse breast tumor via local injections were studied demonstrated. ex...
National Clinical Research Center for Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.