A5101613233- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Optical Imaging and Spectroscopy Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Erythrocyte Function and Pathophysiology
- Ion channel regulation and function
- Thermography and Photoacoustic Techniques
- Ultrasound Imaging and Elastography
- Photodynamic Therapy Research Studies
The University of Texas Southwestern Medical Center
2020-2025
The University of Texas at Arlington
2020-2025
Rice University
2025
Abstract Non‐surgical and safe prostate cancer (PCa) therapies are in demand. Soluble tumor necrosis factor (TNF‐α) related apoptosis inducing ligand (TRAIL), a cancer‐specific drug, shows preclinical efficacy but has short circulation half‐life. This research shown that physiological fluid shear stress activates mechanosensitive ion channels (MSCs), such as Piezo1, enhancing TRAIL‐mediated cells. Herein, noninvasive, focal ultrasound (FUS) is implemented to augment the pro‐apoptotic effects...
The ultrasound-assisted transport of drugs or fluorophore-loaded nanoagents plays an important role in the desirable drug delivery and imaging contrasts. Unlike conventional ultrasound techniques that rely on thermal cavitation effects, this study aims to conduct experimental investigation into dynamics interstitial fluid streaming tissue recovery ex vivo chicken breast porcine loin muscle tissues during after exposures, which has not been experimentally investigated literature. Biological...
The ultrasound-switchable fluorescence (USF) technique was recently developed to achieve high-resolution imaging in centimeters-deep tissue. This study introduced strategies significantly improve sensitivity and depth using an electron multiplying charge-coupled device (EMCCD) camera-based USF system a newly contrast agent of indocyanine green (ICG)-encapsulated liposomes. For quantitative study, phantom sub-millimeter silicone tube embedded centimeter-thick chicken breast tissue adopted...
Measuring the local background temperature in diseased and inflamed tissues is highly desirable, especially a non-invasive way. In this work, ultrasound-switchable fluorescence (USF) technique was utilized to estimate for first time by analyzing dependence of emission from USF contrast agents induced focused ultrasound (FU) beam. First, temperature-sensitive with distinct switching-on thresholds were synthesized, their thermal switching characteristics quantified using an independent...
Liposomes have been widely used in both medical imaging and drug delivery fields due to their excellent biocompatibility easy surface modification. Recently our lab reported for the first-time implementation of temperature-sensitive indocyanine green (ICG)-encapsulated liposome microparticles vivo ultrasound-switchable fluorescence (USF) imaging. A previous study showed that achieved USF centimeter-deep tissue. This aimed control size liposomes at nanoscale effect on depth. Also, we explored...
Abstract Temperature measurements in biological tissues play a crucial role studying metabolic activities. In this study, we introduce noninvasive thermometry technique based on two‐color ultrasound‐switchable fluorescence (USF). This innovative method allows for local temperature mapping within microtube filled with temperature‐sensitive liposomes as nano imaging agents. By measuring the temperature‐dependent emission of using spectrometer, identify four characteristic temperatures. The...