A5028375853- Cystic Fibrosis Research Advances
- Nonmelanoma Skin Cancer Studies
- Malaria Research and Control
- Palliative Care and End-of-Life Issues
- Liver Disease Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Obesity, Physical Activity, Diet
- Inflammatory Bowel Disease
- Neonatal Respiratory Health Research
- Cervical Cancer and HPV Research
- Acute Myocardial Infarction Research
- Microscopic Colitis
- Mosquito-borne diseases and control
- Diabetes Management and Education
- Cancer survivorship and care
- Pelvic floor disorders treatments
- Polyomavirus and related diseases
- Cancer and Skin Lesions
- Inhalation and Respiratory Drug Delivery
- Clinical Reasoning and Diagnostic Skills
- Heart Failure Treatment and Management
- Indigenous Health, Education, and Rights
- Patient-Provider Communication in Healthcare
- Gestational Diabetes Research and Management
- Genetic and phenotypic traits in livestock
QIMR Berghofer Medical Research Institute
2014-2023
Daiseung Medics (South Korea)
2015
The University of Queensland
2002-2014
Royal Brisbane and Women's Hospital
2010-2014
Westmead Institute
2014
Westmead Hospital
2014
The University of Sydney
2014
Greenslopes Private Hospital
2014
Heidelberg University
2011
University Hospital Heidelberg
2011
OBJECTIVE Given the role of gut microbiota in regulating metabolism, probiotics administered during pregnancy might prevent gestational diabetes mellitus (GDM). This question has not previously been studied high-risk overweight and obese pregnant women. We aimed to determine whether (Lactobacillus rhamnosus Bifidobacterium animalis subspecies lactis) from second trimester women GDM as assessed by an oral glucose tolerance test (OGTT) at 28 weeks’ gestation. Secondary outcomes included...
The treatment of infants with bronchiolitis is largely supportive. role bronchodilators controversial. Most studies the use have enrolled small numbers subjects and examined only short-term outcomes, such as clinical scores.
There remain no clear guidelines for the optimal management of patients with metastatic breast cancer. To better understand its natural history, we undertook a detailed examination 197 autopsies performed on women who died We reviewed clinical, treatment and pathological aspects all cases and, additionally, features biomarker expression (ER, PgR, HER2, EGFR, p53, Ki67, c-Kit, CK AE1/AE3) were assessed in detail primary tumour matched metastases 55 cases. Genomes multiple analysed by...
Abstract – Objectives: The aim of this study was to investigate the association between selected social and behavioural variables pattern severity early childhood caries (ECC) within a community child population. Methods: A cross‐sectional sample 2515 children aged 4–5 years were examined in preschool setting using decayed, missing, filled teeth/surface (dmft/dmfs) indices self‐administered questionnaire used obtain information regarding social, demographic, birth, infant feeding, oral...
Background Critical to the development of new drugs for treatment malaria is capacity safely evaluate their activity in human subjects. The approach that has been most commonly used testing subjects with natural infection, a methodology may expose symptomatic risk ineffective treatment. Here we describe and pilot system undertake experimental infection using blood stage Plasmodium falciparum parasites (BSP). objectives study were assess feasibility safety induced BSP as method assessment...
Older medical patients often experience a decline in function associated with hospitalization. Some of this is already established at hospital admission, whereas some occurs during Objectives study were to separately describe pre-hospital and in-hospital functional changes older Australian identify risk factors these changes.Secondary analysis data from prospective controlled trial conducted general units an tertiary teaching hospital. Participants 615 consecutive aged 65 years or admitted...
Serology has been used to indicate past infection by the human polyomaviruses BK virus (BKV) and JC (JCV), because site of primary is not established fully. Little known about BKV JCV antibody stability over time. We investigated seroprevalence time in an Australian population-based study. Serum was collected from 458 adults participating a longitudinal skin cancer study Queensland 1992, 1993 1996, 117 people had fourth sample 2003. samples were analysed for VP1 antibodies multiplex...
<h3>Background:</h3> <i>Pseudomonas aeruginosa</i> is the most common bacterial pathogen in patients with cystic fibrosis (CF). Current infection control guidelines aim to prevent transmission via contact and respiratory droplet routes do not consider possibility of airborne transmission. It was hypothesised that subjects CF produce viable respirable aerosols coughing. <h3>Methods:</h3> A cross-sectional study undertaken 15 children 13 adults CF, 26 chronically infected <i>P aeruginosa</i>....
Ferroquine (SSR97193) is a candidate anti-malarial currently undergoing clinical trials for malaria. To better understand its pharmacokinetic (PK) and pharmacodynamic (PD) parameters the compound was tested in experimentally induced blood stage malaria infection model volunteers. Male non-pregnant female aged 18–50 years were screened this phase II, controlled, single-centre trial. Subjects inoculated with ~1800 viable Plasmodium falciparum 3D7A-infected human erythrocytes, treated...
Pregnancies with a macrosomic fetus comprise subgroup of high-risk pregnancies. There is uncertainty in the clinical management and outcomes such pregnancies.We sought to examine maternal fetal pregnancies infants at Royal Brisbane Women's Hospital (RBWH).Data from 276 births (weighing > or = 4500 g) 294 controls 3250-3750 delivered during 2002-2004 RBWH were collected hospital database. Univariate logistic regression analyses performed for risk factors neonatal that associated...
Abstract Objective The objective of this paper is to determine changes in supportive care needs after first‐line treatment for ovarian cancer and identify risk factors future unmet needs. Methods Two hundred nineteen women with were asked complete a baseline survey 6–12 months diagnosis then follow‐up surveys every 6 up 2 years. validated Supportive Care Needs Survey‐Short Form measured 34 across five domains. Logistic regression identified variables associated Results At baseline,...
<h3>Background</h3> Person-to-person transmission of respiratory pathogens, including <i>Pseudomonas aeruginosa</i>, is a challenge facing many cystic fibrosis (CF) centres. Viable <i>P aeruginosa</i> are contained in aerosols produced during coughing, raising the possibility airborne transmission. <h3>Methods</h3> Using purpose-built equipment, we measured viable cough at 1, 2 and 4 m from subject (distance) after allowing to age for 5, 15 45 min slowly rotating drum minimise gravitational...
Obesity is increasing in the child-bearing population as are rates of gestational diabetes. Gestational diabetes associated with higher Cesarean Section for mother and increased risks macrosomia, body fat mass, respiratory distress hypoglycemia infant. Prevention through life style intervention has proven to be difficult. A Finnish study showed that ingestion specific probiotics altered composition gut microbiome thereby metabolism from early gestation decreased normal weight women. In...
Group A streptococcus (GAS) is a serious human pathogen that affects people of different ages and socio-economic levels. Although vaccination potentially one the most effective methods to control GAS infection its sequelae, few prototype vaccines have been investigated in humans. In this study, we report safety immunogenicity novel acetylated peptide-protein conjugate vaccine candidate MJ8VAX (J8-DT), when delivered intramuscularly healthy adults.A randomized, double-blinded, controlled...
OZ439, or artefenomel, is an investigational synthetic ozonide antimalarial with similar potency, but a significantly improved pharmacokinetic profile, compared artemisinins. We wished to measure key and pharmacodynamic parameters the pharmacokinetic/pharmacodynamic relationship of artefenomel in humans guide drug's further development as combination therapy patients. tested human induced blood-stage malaria (IBSM) model. Plasmodium infection was monitored by quantitative PCR (qPCR) upon...
Background. Piperaquine, coformulated with dihydroartemisinin, is a component of widely used artemisinin combination therapy. There paucity data on its antimalarial activity as single agent. Such data, if available, would inform selection new coformulations. Methods. We undertook study in healthy subjects, using the induced blood stage malaria (IBSM) model to test doses piperaquine (960, 640, and 480 mg) 3 cohorts. In pilot third cohort, gametocyte clearance following administration 15 mg,...
The purpose of the study is to identify factors predictive outcome after open globe injury in 273 patients admitted Royal Brisbane Hospital, Queensland, Australia between 1992 and 2003.Data were collected retrospectively regarding demographic geographical factors, circumstances, initial visual acuity (VA), parameters, details subsequent surgery, final best corrected VA complications. Multivariate analysis using binary logistic regression was utilized which related outcome.83% male, with a...