A5043930273- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Birth, Development, and Health
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Ovarian cancer diagnosis and treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism and Genetic Disorders
- Breastfeeding Practices and Influences
- RNA Research and Splicing
- Genetic Associations and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Renal and related cancers
- Lipid metabolism and disorders
- Infant Nutrition and Health
- Diet, Metabolism, and Disease
- Reproductive Biology and Fertility
- Advanced Proteomics Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
Baker Heart and Diabetes Institute
2021-2025
Massachusetts General Hospital
2024-2025
Harvard University
2024-2025
The University of Melbourne
2020
Sorbonne Université
1982-1985
Unité de recherche sur les maladies cardiovasculaires et métaboliques
1982
Alzheimer's disease (AD) is a major neurodegenerative disorder with significant environmental factors, including diet and lifestyle, influencing its onset progression. Although previous studies have suggested that certain diets may reduce the incidence of AD, underlying mechanisms remain unclear. In this post-hoc analysis randomized crossover study 20 elderly adults, we investigated effects modified Mediterranean ketogenic (MMKD) on plasma lipidome in context AD biomarkers, analyzing 784...
Rationale: Mitochondrial dysfunction facilitates heart failure development forming a therapeutic target, but the mechanism involved remains unclear. We studied whether Hippo signaling pathway mediates mitochondrial abnormalities that results in onset of dilated cardiomyopathy (DCM). Methods: Mice with DCM due to overexpression kinase Mst1 were studied. phenotype was evident adult animals contractile identified as an early sign at 3 weeks postnatal. Electron microscopy, multi-omics and...
Accurate risk stratification is vital for primary prevention of cardiovascular disease (CVD). However, traditional tools such as the Framingham Risk Score (FRS) may underperform within diverse intermediate-risk group, which includes individuals requiring distinct management strategies. This study aimed to develop a lipidomic-enhanced score (LRS), specifically targeting prediction and reclassification intermediate benchmarked against FRS. The LRS was developed via machine learning workflow...
VITT has emerged as a rare but serious adverse event linked primarily to adenoviral vector COVID-19 vaccinations, such ChAdOx1-S (Oxford/AstraZeneca) vaccination. The syndrome is characterized by thrombosis with thrombocytopenia, elevated D-dimer, and pathologic platelet factor 4 antibodies within 42 days of Despite dysregulated lipid metabolism underpinning many thrombotic conditions, the role alterations in remains unexplored. Here, we examined plasma lipidome patients compared it those...
During mitochondrial damage, information is relayed between the mitochondria and nucleus to coordinate precise responses preserve cellular health. One such pathway integrated stress response (mtISR), which known be activated by DNA (mtDNA) damage. However, causal molecular signals responsible for activation of mtISR remain mostly unknown. A gene often associated with mtDNA mutations/deletions Polg1, encodes Polymerase γ (PolG). Here, we describe an inducible, tissue specific model PolG...
Abstract Introduction The apolipoprotein E ( APOE ) genotype is the strongest genetic risk factor for late‐onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating disease risk, poorly understood. Methods We performed lipidomic analysis three independent cohorts (the Australian Imaging, Biomarkers Lifestyle [AIBL] flagship study, n = 1087; Disease Neuroimaging Initiative [ADNI] 1 819; Busselton Health Study [BHS], 4384), we defined associations between...
Background: There is mounting evidence that in utero and early life exposures may predispose an individual to metabolic disorders later life; dysregulation of lipid metabolism critical such outcomes. However, there limited knowledge about factors causing could result adverse health outcomes life. We studied the effect antenatal as gestational age, birth weight, mode on at birth; changes circulating lipidome first 4 years breastfeeding year From this study, we aim generate a framework for...
Abstract Extracellular vesicles (EVs) are now being increasingly recognized as an essential signaling entity in human plasma, linking them to health and various diseases. Still, their core protein lipid componentry, which lie at the center of EV form function, remains poorly defined. Achieving this unmet milestone greatly hindered by abundant non-vesicular extracellular plasma components (non-EVs) mass spectrometry-based analyses. Here, we performed high-resolution density gradient...
Anti-Müllerian hormone (AMH) protects the ovarian reserve from chemotherapy, and this effect is most pronounced with Doxorubicin (DOX). However, DOX toxicity AMH rescue mechanisms in ovary have remained unclear. Herein, we characterize consequences of these treatments cell types using scRNAseq. DOX-induced DNA damage activates Tp53 class mediators across types. In mesenchyme, cotreatment halts theca progenitor differentiation reduces apoptotic gene expression. preantral granulosa cells,...
<title>Abstract</title> Diet is a key factor for many diseases, yet the underlying metabolic pathways involved remain poorly understood. We analyzed data from 13,335 participants across two large Australian cohorts examining comprehensive lipidomic profiles in relation to diet. also assessed link between signatures of dietary quality with cardiometabolic health and all-cause mortality. Here, we report characteristic linked dairy [sphingomyelins lipids esterified 14:0, 15:0, 17:0 or 17:1...
Plasmalogens are a distinct subclass of glycerophospholipids that exhibit unique structural features, notably possessing vinyl ether linkage at the sn1 position glycerol backbone. These specialised lipids play crucial roles in various biological functions. Although biosynthetic pathway plasmalogens has been well-characterised, their catabolism remains less studied. In this study, we investigated impact global and tissue-specific loss-of-function plasmalogen catabolising enzyme,...
Abstract Recent advancements in plasma lipidomic profiling methodology have significantly increased specificity and accuracy of lipid measurements. This evolution, driven by improved chromatographic mass spectrometric resolution newer platforms, has made it challenging to align datasets created at different times, or on platforms. Here we present a framework for harmonising such with levels granularity their Our method utilises elastic-net prediction models, constructed from high-resolution...
Takotsubo syndrome (TTS) is characterized by short-term contractile dysfunction with its mechanism undefined. We showed that activation of cardiac Hippo pathway mediates mitochondrial and stimulation β-adrenoceptors (βAR) activates pathway. Here, we investigated the role βAR-Hippo signaling in mediating isoproterenol (Iso)-induced TTS-like mouse model. Elderly postmenopausal female mice were administered Iso (1.25 mg/kg/h for 23 h). Cardiac function was determined serially echocardiography....
Breastfed infants have lower disease risk compared to formula-fed infants, however, the mechanisms behind this protection are unknown. Human milk has a complex lipidome which may many critical roles in health and risk. However, human lipidomics is challenging, research still required fully understand interpret translate findings. This study aimed address key knowledge gaps discuss possible implications for early life health.Human samples from two birth cohorts, Barwon Infant Study (n = 312)...
We assessed the impact of intravenous fentanyl and lignocaine on pharmacokinetics pharmacodynamics ticagrelor in patients with unstable angina non-ST-elevation myocardial infarction their procedural analgesic efficacy safety.Seventy undergoing coronary angiography loading were included pharmacokinetic pharmacodynamic analyses this randomized trial. Plasma levels 2 h post-loading dose significantly lower arm than treatment (598 vs. 1008 ng/mL, P = 0.014). The area under plasma-time curves for...
Elevated circulating sphingolipids are associated with shorter overall survival and therapeutic resistance in metastatic castration-resistant prostate cancer (mCRPC), suggesting that perturbations sphingolipid metabolism promotes growth. This study assessed whether addition of simvastatin to standard treatment for mCRPC can modify a poor prognostic lipidomic profile represented by validated 3-lipid signature (3LS). Men (n = 27) who were not on lipid-lowering agent, given 12 weeks (40 mg...
Summary Anti-Müllerian hormone (AMH) protects the ovarian reserve from chemotherapy, and this effect is most pronounced with Doxorubicin (DOX). However, mechanisms of DOX toxicity AMH rescue in ovary remain unclear. Herein, we characterize these various cell types using scRNAseq. In mesenchyme, activates intrinsic apoptotic signaling pathway through p53 class mediators, particularly affecting theca progenitors, while co-treament halts differentiation reduces gene expression. preantral...
Introduction Cardiovascular disease (CVD) is the leading cause of mortality worldwide and death in US. Lipid dysregulation a well-known precursor to metabolic diseases, including CVD. There growing body literature that suggests MRI-derived epicardial fat volume, or adipose tissue (EAT) linked development coronary artery disease. Interestingly, also actively involved lipid energy homeostasis, with having greater capacity for release uptake free fatty acids. However, there scarcity knowledge...
ABSTRACT Alzheimer’s disease (AD) is a major neurodegenerative disorder with significant environmental factors, including diet and lifestyle, influencing its onset progression. Although previous studies have suggested that certain diets may reduce the incidence of AD, underlying mechanisms remain unclear. In this randomized crossover study 20 elderly adults, we investigated effects modified Mediterranean ketogenic (MMKD) on plasma lipidome, analyzing 784 lipid species across 47 classes. We...
The systemic inflammatory response syndrome (SIRS) is a dysregulated that contributes to critical illness. Adjunctive acetylsalicylic acid (ASA) treatment may offer beneficial effects by increasing the synthesis of specialised proresolving mediators (a subset polyunsaturated fatty acid-derived lipid mediators).Pilot, feasibility, multicentre, double-blind, randomised, placebo-controlled trial.Four interdisciplinary intensive care units (ICUs) in Australia.Critically ill patients with...
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder with significant environmental factors, including diet, that influence its onset and progression. While the ketogenic diet (KD) holds promise in reducing metabolic risks potentially affecting AD progression, only few studies have explored KD’s molecular impact for markers of therapeutic potential. The BEAM study simultaneously profiled effect on lipidome, blood cerebrospinal metabolome, microbiome both cognitively...