A5024713807- Vitamin C and Antioxidants Research
- Sepsis Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Intensive Care Unit Cognitive Disorders
- Diabetes Management and Research
- Vitamin K Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Failure Treatment and Management
- Hemodynamic Monitoring and Therapy
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Anesthesia and Sedative Agents
- Diabetes and associated disorders
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury Research
- Metabolomics and Mass Spectrometry Studies
- Delphi Technique in Research
- Frailty in Older Adults
- Optical Imaging and Spectroscopy Techniques
- Climate Change and Health Impacts
- Fatty Acid Research and Health
- Pharmaceutical Practices and Patient Outcomes
University Children's Hospital Zurich
2024-2025
University of Zurich
2024-2025
University Hospital of Bern
2019-2024
University of Bern
2020-2024
Monash University
2017-2023
Australian and New Zealand Intensive Care Society
2019-2023
Austin Hospital
2016-2020
The University of Melbourne
2016-2020
Institute of Social and Preventive Medicine
2020
It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock. To determine the combination thiamine, compared with alone, improves duration time alive free vasopressor administration patients Multicenter, open-label, randomized clinical trial conducted 10 intensive care units Australia, New Zealand, Brazil that recruited 216 fulfilling Sepsis-3 definition The first patient was enrolled on May 8, 2018, last...
Abstract Background Septic shock is associated with decreased vasopressor responsiveness. Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase responsiveness and reduce catecholamine requirements in septic shock. However, DEX may also cause hypotension bradycardia. Thus, it remains unclear whether hemodynamically safe or helpful this setting. Methods In post hoc subgroup analysis of the Sedation Practice Intensive Care Evaluation (SPICE III) trial, an...
To assess the feasibility, biochemical efficacy, and safety of liberal versus conventional glucose control in ICU patients with diabetes.Prospective, open-label, sequential period study.A 22-bed mixed a tertiary hospital Australia.We compared 350 consecutive diabetes admitted over 15 months who received preintervention population control.Liberal insulin therapy if was greater than 14 mmol/L (target: 10-14 [180-252 mg/dL]). Conventional 10 6-10 [108-180 mg/dL]).We assessed separation blood...
Normal saline (NS) is the most commonly used crystalloid solution worldwide but contains an excess of chloride and may cause metabolic acidosis hyperchloraemia. Such abnormalities be attenuated by use a balanced such as Plasma-Lyte 148 (PL-148).To assess feasibility, safety biochemical physiological effects resuscitation with NS versus PL-148 in critically ill patients.An exploratory, multicentre, doubleblind, randomised controlled trial involving patients aged ≥ 18 years who were...
Sodium glucose co-transporter-2 (SGLT2) inhibitors improve long-term cardiovascular and renal outcomes in individuals with type 2 diabetes. However, the safety of SGLT2 ICU patients diabetes is uncertain. We aimed to perform a pilot study assess relationship between empagliflozin therapy biochemical, clinical such patients.We included 18 receiving (10 mg daily) insulin target range 10-14 mmol/l according our liberal control protocol for (treatment group). Treatment group were matched on age,...
Glycated hemoglobin A1c is used to estimate glycemic control. However, its value upon ICU admission may be altered by critical illness and not reflect true status. We assessed the relationship between glycated premorbid levels.Retrospective observational cohort study.Two tertiary ICUs in Australia.Cohort of 69 critically ill patients with diabetes levels measured during month prior admission.Measurement A1c.Mean (SD) level was 7.5% (1.8%) 7.8% (2.0%) previous measurements from preceding 30...
Objectives: To study vitamin C pharmacokinetics in septic shock. Design: Prospective pharmacokinetic study. Setting: Two intensive care units. Participants: Twenty-one patients with shock enrolled a randomised trial of high dose therapy Intervention: Patients received 1.5 g intravenous every 6 hours. Plasma samples were obtained before and at 1, 4 hours after drug administration, concentrations measured by performance liquid chromatography. Main outcome measures: Clearance, volume...
It is uncertain whether liberal glucose control in critically ill diabetic patients leads to increased ketone production and ketoacidosis. Therefore, we aimed assess the prevalence of ketosis, ketonuria ketoacidosis treated accordance with a glycemic protocol. We performed prospective observational cohort study 60 blood and/or urine bodies tested ICU. All were according protocol targeting level (BGL) between 10 14 mmol/l single tertiary intensive care unit Australia. measured quantitative...
Septic shock is associated with poor outcomes. Vitamin C (ascorbic acid) a cellular antioxidant and has anti-inflammatory properties. Whether the combination therapy of vitamin C, thiamine hydrocortisone reduces vasopressor dependency in septic unclear.To describe protocol statistical analysis plan multicentre, open-label, prospective, phase 2 randomised clinical trial evaluating effects when compared monotherapy on duration administration critically ill patients shock.VITAMINS multicentre...
Objective: To assess the physiological, biochemical and haemodynamic response to a single intravenous (IV) dose of frusemide in critically patients. Design, setting patients: A prospective observational study 21 ill patients tertiary intensive care unit Australia. Interventions: We collected information on urine output (UO), fluid balance, serum urinary electrolyte levels, levels haemodynamics. compared data from 6-hour period before administration IV bolus 40 mg with after administration....
Recombinant erythropoietin (EPO) administered for traumatic brain injury (TBI) may increase short-term survival, but the long-term effect is unknown. We conducted a pre-planned follow-up of patients in multicentre TBI trial (2010–2015). invited survivors to and evaluated survival functional outcome with Glasgow Outcome Scale-Extended (GOSE) (categories 5–8 = good outcome), secondly, determined relative baseline function (sliding scale). used analysis assess time death absolute risk...
Background There are increasing calls to establish heart failure (HF) clinics due their effectiveness in the interdisciplinary management of people living with HF. However, although a recommendation exists for palliative care (PC) providers be part team, few established HF include them teams. Therefore, this qualitative study, we aimed understand unmet PC needs patients attending an already clinic. Methods Secondary analysis structured interviews undertaken within larger study validate...
In critically ill patients with permissive hyperglycemia, it is uncertain whether exogenous insulin administration suppresses or enhances c-peptide secretion (a marker of pancreatic beta-cell response). We aimed to explore this effect in type 2 diabetes. prospectively enrolled a cohort 45 diabetes managed according liberal glucose protocol (target blood 10–14 mmol/l). recorded the and oral hypoglycemic agents measured plasma as surrogate endogenous on first two consecutive days ICU. Overall,...
Background Critically ill patients with diabetes mellitus (DM) are at increased risk of in‐hospital complications and the optimal glycemic target for such remains unclear. A more liberal approach to glucose control has recently been suggested DM, but uncertainty regarding its impact on complications. Methods We aimed test hypothesis that would be common a in ICU DM. Thus, we compared hospital‐acquired first 400 critically DM included sequential before‐and‐after trial (glucose target: 10‐14...
Abstract Background The Needs Assessment Tool: Progressive Disease-Heart Failure (NAT: PD-HF) is a tool created to assess the needs of people living with heart failure and their informal caregivers assist delivering care in more comprehensive way that addresses actual are unmet, improve quality life. In this study, we aimed (1) Translate into German culturally adapt it. (2) Assess internal consistency, inter-rater reliability, test–retest reliability NAT: PD-HF. (3) Evaluate whether how...