Frances Bass
A5047177388- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Diabetes Management and Research
- Family and Patient Care in Intensive Care Units
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Chronic Kidney Disease and Diabetes
- Palliative Care and End-of-Life Issues
- Acute Kidney Injury Research
- Traumatic Brain Injury Research
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Dialysis and Renal Disease Management
- Cardiovascular Function and Risk Factors
- Clinical Reasoning and Diagnostic Skills
- Trauma Management and Diagnosis
- Thermal Regulation in Medicine
- Climate Change and Health Impacts
Royal North Shore Hospital
2014-2025
The George Institute for Global Health
2015-2025
UNSW Sydney
2012-2025
Edward Francis Small Teaching Hospital
2025
University of Ottawa
2024
Ottawa Hospital
2024
Université de Montréal
2024
Families USA
2023
Alberta Health Services
2022
University of Alberta
2022
Choice and intensity of early (first 48 h) sedation may affect short- long-term outcome.To investigate the relationships between time to extubation, delirium, hospital 180-day mortality among ventilated critically ill patients in intensive care unit (ICU).Multicenter (25 Australia New Zealand hospitals) prospective longitudinal (ICU admission 28 d) cohort study medical/surgical sedated 24 hours or more. We assessed administration sedative agents, ventilation time, depth using Richmond...
Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration mechanical ventilation delirium among patients in intensive care unit (ICU). The use dexmedetomidine as sole or primary sedative agent undergoing has not been extensively studied.
<h3>Objective:</h3> To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by American Clinical Neurophysiology Society. <h3>Methods:</h3> In this cohort study, 4 specialists, blinded outcome, evaluated prospectively recorded EEGs Target Temperature Management trial (TTM trial) that randomized 33°C vs 36°C. Routine was performed still rewarming. were classified into...
Commonly used sedatives/analgesics can increase the risk of postoperative complications, including delirium. This double-blinded study assessed neurobehavioral, hemodynamic, and sedative characteristics dexmedetomidine compared with morphine-based regimen after cardiac surgery at equivalent levels sedation analgesia.A total 306 patients least 60 yr old were randomized to receive (0.1-0.7 microg x kg(-1) h(-1)) or morphine (10-70 open-label propofol titrated a target Motor Activity Assessment...
Importance Whether selective decontamination of the digestive tract (SDD) reduces mortality in critically ill patients remains uncertain. Objective To determine whether SDD in-hospital adults. Design, Setting, and Participants A cluster, crossover, randomized clinical trial that recruited 5982 mechanically ventilated adults from 19 intensive care units (ICUs) Australia between April 2018 May 2021 (final follow-up, August 2021). contemporaneous ecological assessment 8599 participating ICUs...
Abstract Background Sedation is often provided to resuscitated out‐of‐hospital cardiac arrest (OHCA) patients tolerate post‐cardiac care, including temperature management. However, the evidence of benefit or harm from routinely administered deep sedation after limited. The aim this trial investigate effects continuous compared minimal on patient‐important outcomes in OHCA a large clinical trial. Methods SED‐CARE part 2 × factorial Sedation, Temperature and Pressure Cardiac Arrest...
Objective: To assess the feasibility and safety of delivering early goal-directed sedation compared with standard sedation. Design: Pilot prospective, multicenter, randomized, controlled trial. Setting: Six ICUs. Patients: Critically ill adults mechanically ventilated for greater than 24 hours. Interventions: Patients randomized to received a dexmedetomidine-based algorithm targeted light (Richmond Agitation Sedation Score –2 1). propofol and/or midazolam-based as clinically appropriate....
Abstract Background Septic shock is associated with decreased vasopressor responsiveness. Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase responsiveness and reduce catecholamine requirements in septic shock. However, DEX may also cause hypotension bradycardia. Thus, it remains unclear whether hemodynamically safe or helpful this setting. Methods In post hoc subgroup analysis of the Sedation Practice Intensive Care Evaluation (SPICE III) trial, an...
Abstract Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values partial pressure (PaO 2 ) and episodes hypoxemia hyperoxemia occurring within first 72 h mechanical ventilation out hospital (OHCA) patients. secondary evaluate association PaO with patients’ outcome. Methods Preplanned analysis targeted hypothermia versus normothermia OHCA (TTM2) trial. Arterial blood gases were collected from...
The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. aim of this study was to describe the applied first 72 h mechanical ventilation out-of-hospital 6-month outcomes. Preplanned sub-analysis Target Temperature Management-2 trial. Clinical outcomes were mortality functional status (assessed by Modified Rankin Scale) 6 months randomization. A total 1848 included (mean age 64 [Standard Deviation, SD = 14] years). At months, 950...
BackgroundThe effect of a liberal red-cell transfusion strategy as compared with restrictive in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear.MethodsWe randomly assigned critically ill adults acute and anemia to (mandatory at hemoglobin level ≤10 g per deciliter) or (optional ≤8 deciliter). The primary outcome was unfavorable neurologic outcome, defined score 4 higher on modified Rankin scale (range, 0 6, scores indicating greater disability)...
The 2021 guidelines endorsed by the European Resuscitation Council (ERC) and Society of Intensive Care Medicine (ESICM) recommend using highly malignant electroencephalogram (EEG) patterns (HMEP; suppression or burst-suppression) at > 24 h after cardiac arrest (CA) in combination with least one other concordant predictor to prognosticate poor neurological outcome. We evaluated prognostic accuracy HMEP a large multicentre cohort investigated added value absent EEG reactivity. This is...
Abstract Background Basic management for patients who have suffered a cardiac arrest and are admitted to an intensive care unit (ICU) after resuscitation includes setting targets blood pressure managing sedation temperature. However, optimal unknown. Methods The STEPCARE (Sedation, Temperature Pressure Cardiac Arrest Resuscitation) trial is multicenter, parallel‐group, randomized, factorial, superiority in which sedation, temperature, strategies will be studied three separate comparisons...
Rationale: The SPICE III (Sedation Practice in Intensive Care Evaluation) trial reported significant heterogeneity mortality with dexmedetomidine treatment. Supplemental propofol was commonly used to achieve desirable sedation. Objectives: To quantify the association of different infusion rates and propofol, given combination, determine if this is modified by age. Methods: We included 1,177 patients randomized receive supplemental stratified age (>65 or ⩽65 yr). double stratification...
The Targeted Hypothermia vs Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison 2 intervention regimens.To investigate effects targeted hypothermia normothermia on with focus societal participation and cognitive function survivors OHCA.This study is a an...
Objectives: To compare estimates of the incidence and mortality sepsis septic shock among patients in Australian intensive care units (ICUs) according to clinical diagnoses or binational database (ANZICS CORE) methodology. Design, setting, participants: Prospective inception cohort study (3-month period, 1 October – 31 December 2016, with 60-day follow-up); daily screening all a tertiary hospital 60-bed multidisciplinary ICU. Main outcomes: Diagnoses criteria criteria; in-hospital (censored...
Ventilated patients receiving opioids and/or benzodiazepines are at high risk of developing agitation, particularly upon weaning towards extubation. This is often associated with an increased intubation time and length stay in the intensive care unit may cause long-term morbidity. Anxiety, fear agitation amongst most common non-pulmonary causes failure to liberate from mechanical ventilation. prospective, open-label observational study examined 28 ventilated adult (30 episodes) requiring...
Background Diarrhoea remains a leading cause of death in children. An intestinal adsorbent may reduce diarrhoea duration and severity. Methods Randomised controlled feasibility trial with two phases: phase 1 (0–4 hours double-blind) 2 (up to 5 days open-label). 50 children aged 6–59 months acute presenting no or some dehydration the emergency paediatric unit outpatient clinic at Edward Francis Small Teaching Hospital, Banjul, The Gambia were randomised either standard treatment (oral...
Fever is associated with brain injury after cardiac arrest. It unknown whether fever management a feedback-controlled device impacts patient-centered outcomes in arrest patients. This trial aims to investigate or without temperature control out-of-hospital The TEMP-CARE part of the 2 × factorial Sedation, TEmperature and Pressure Cardiac Arrest REsuscitation (STEPCARE) trial, randomized, international, multicenter, parallel-group, investigator-initiated, superiority that will evaluate...
<title>Abstract</title> <bold>Background:</bold> This study assessed the accuracy of three International Classification Diseases (ICD) codes methods derived from Global Burden Disease (GBD) sepsis (modified GBD method) in identifying sepsis, compared to Angus method. Sources errors these were also reported. <bold>Methods:</bold> Prospective multicentre, observational, study. Emergency Department patients aged <underline>></underline>16 years with high risk nine hospitals NSW, Australia...
Abstract Background In patients resuscitated after cardiac arrest, a higher mean arterial pressure (MAP) may increase cerebral perfusion and attenuate hypoxic brain injury. Here we present the protocol of arrest resuscitation (MAP‐CARE) trial aiming to investigate influence MAP targets on patient outcomes. Methods ‐ CARE is one component Sedation, Temperature Pressure Cardiac Arrest Resuscitation ( STEPCARE ) 2 x factorial randomized trial. The an international, multicenter, parallel‐group,...
Ventriculostomy-related infections (VRIs) are reported in about 10 % of patients with external ventricular drains (EVDs). VRIs difficult to diagnose due clinical and laboratory abnormalities caused by the primary neurological injury which led insertion EVD. Polymerase chain reaction (PCR) cerebrospinal fluid (CSF) may enable more accurate diagnosis VRI. We performed a prospective cohort study measure incidence VRI as diagnosed 16S rRNA PCR.
Recombinant erythropoietin (EPO) administered for traumatic brain injury (TBI) may increase short-term survival, but the long-term effect is unknown. We conducted a pre-planned follow-up of patients in multicentre TBI trial (2010–2015). invited survivors to and evaluated survival functional outcome with Glasgow Outcome Scale-Extended (GOSE) (categories 5–8 = good outcome), secondly, determined relative baseline function (sliding scale). used analysis assess time death absolute risk...