A5037463347- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Adolescent and Pediatric Healthcare
- Digital Mental Health Interventions
- Mental Health Treatment and Access
- Treatment of Major Depression
- Educational Research and Pedagogy
- Psychotherapy Techniques and Applications
- Eating Disorders and Behaviors
- COVID-19 and Mental Health
- Behavioral Health and Interventions
- Obesity, Physical Activity, Diet
- Education and Learning Interventions
- Cardiac Arrest and Resuscitation
- Emotions and Moral Behavior
- Education, Safety, and Science Studies
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Family Caregiving in Mental Illness
- Mindfulness and Compassion Interventions
- Personality Disorders and Psychopathology
University of Exeter
2016-2025
Clinical Trial Investigators
2025
Singer (United States)
2009-2024
Rice University
2024
University Hospitals Bristol NHS Foundation Trust
2023
University Hospitals Bristol and Weston NHS Foundation Trust
2023
University of Bristol
2023
NIHR Bristol Cardiovascular Biomedical Research Unit
2023
University of Colorado Health
2015
Stephen F. Austin State University
2014
Background: Despite the use of mood stabilizers, a significant proportion patients with bipolar affective disorder experience frequent relapses.A pilot study cognitive therapy (CT) specifically designed to prevent relapses for showed encouraging results when used in conjunction stabilizers.This article reports outcome randomized controlled CT help and promote social functioning. Methods:We 103 1 according DSM-IV, who experienced despite prescription commonly into group or control group.Both...
BackgroundDepression is a common, debilitating, and costly disorder. Many patients request psychological therapy, but the best-evidenced therapy—cognitive behavioural therapy (CBT)—is complex costly. A simpler therapy—behavioural activation (BA)—might be as effective cheaper than CBT. We aimed to establish clinical efficacy cost-effectiveness of BA compared with CBT for adults depression.MethodsIn this randomised, controlled, non-inferiority trial, we recruited aged 18 years or older meeting...
OBJECTIVE: In a previous randomized controlled study, the authors reported significant beneficial effects of cognitive therapy for relapse prevention in bipolar disorder patients up to 1 year. This study reports additional 18-month follow-up data and presents an overview effect over 30 months. METHOD: Patients with DSM-IV I (N=103) suffering from frequent relapses were randomly assigned into plus medication group or control condition only. Independent raters, who blind patient status,...
Self-compassion and its cultivation in psychological interventions are associated with improved mental health well-being. However, the underlying processes for this not well understood. We randomly assigned 135 participants to study effect of two short-term self-compassion exercises on self-reported-state mood psychophysiological responses compared three control conditions negative (rumination), neutral, positive (excitement) valence. Increased self-compassion, affiliative affect, decreased...
BackgroundAnhedonia (reduced interest/pleasure) symptoms and wellbeing deficits are core to depression predict a poor prognosis. Current psychotherapies fail target these features adequately, contributing sub-optimal outcomes. Augmented Depression Therapy (ADepT) has been developed anhedonia wellbeing. We aimed establish clinical economic proof of concept for ADepT examine feasibility future definitive trial comparing Cognitive Behavioural (CBT).MethodsIn this single-centre, open-label,...
We have reported the advantageous clinical outcome of adding cognitive therapy to medication in prevention relapse bipolar disorder.This 30-month study compares cost-effectiveness with standard care.We randomly allocated 103 individuals 1 disorder treatment and plus treatment. Service use costs were measured at 3-month intervals was assessed using net-benefit approach.The group receiving had significantly better outcomes. The extra offset by reduced service elsewhere. probability being...
The Targeted Hypothermia vs Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison 2 intervention regimens.To investigate effects targeted hypothermia normothermia on with focus societal participation and cognitive function survivors OHCA.This study is a an...
Cognitive therapy (CT) for bipolar disorder emphasizes the monitoring and regulation of mood, thoughts behaviour. The Sense Hyper-Positive Self Scale (SHPSS) measures extent to which patients value themselves perceive possess personal attributes (e.g. dynamism, persuasiveness productiveness) associated with a state being 'mildly high', does not reach severity clinical hypomania. It is hypothesized that who score highly on SHPSS do respond well cognitive therapy.One hundred three bipolar-I...
The landscape of current cancer immunotherapy is dominated by antibodies targeting PD-1/PD-L1 and CTLA-4 that have transformed therapy, yet their efficacy limited primary acquired resistance. blockade additional immune checkpoints, especially TIGIT LAG-3, has been extensively explored, but so far only a LAG-3 antibody approved for combination with nivolumab to treat unresectable or metastatic melanoma. Here we report the development PDL1 × bi-specific (bsAb) GB265, LAG3 bsAb GB266,...
Abstract The majority of research into the mental health benefits blue space (outdoor places where water is a central feature) has focussed on associations between neighbourhood exposure to these spaces and population‐level incidence unipolar depression or anxiety disorder. There been little exploration therapeutic use by those navigating bipolar, schizophrenia other psychotic conditions. Knowledge arising from such an could assist in design optimisation nature‐based care for people with...
This study investigated the possibility that, in remitted bipolar I affective disorder, dysfunctional attitudes are mood-state dependent. Participants were 120 individuals with unipolar depression, or no history of disorder. The Dysfunctional Attitudes Scale (DAS; Weissman, 1979) was completed before and after positive negative mood challenge. Following increase, group changed significantly less DAS total score than did other 2 groups, goal-striving achievement relative to group. These...
Background Depression is a common, debilitating and costly disorder. The best-evidenced psychological therapy – cognitive–behavioural (CBT) complex costly. A simpler therapy, behavioural activation (BA), may be an effective alternative. Objectives To determine the clinical effectiveness cost-effectiveness of BA compared with CBT for depressed adults at 12 18 months’ follow-up, to investigate processes treatments. Design Randomised controlled, non-inferiority trial stratified by depression...
The eating habits of children and adults have been impacted by the COVID-19 pandemic, with evidence increases in snacking emotional eating, including to relieve boredom. We explored experiences families aged 4-8 years who had recently participated a healthy pilot trial when first national lockdown began England.Eleven mothers were interviewed April May 2020. Interview questions developed based on COM-B model behaviour. Four main themes constructed using inductive thematic analysis.The theme...
Objectives The current study aimed to explore participants’ views on the acceptability, impact and mechanisms of change Augmented Depression Therapy (ADepT), a novel wellbeing-focused recovery-oriented psychological therapy for depression. Design A semi-structured qualitative interview design was used, with data analysed using framework approach. Participants 20 participants anhedonic depression who had received up sessions ADepT, sampled from pilot randomised controlled trial ADepT versus...
Bipolar disorder (BD) and emotion dysregulation present substantial challenges for individuals healthcare providers. Although pharmacological treatments remain the primary approach, psychosocial interventions show promise in addressing sub-threshold symptoms deepening understanding of mood mechanisms. The European Network Emotion Regulation (ENBER) aims to close gap between research clinical practice by offering practical insights clinicians while contributing scientific discourse on BD...
Cognitive behaviour therapy (CBT) is an effective treatment for depression. However, CBT a complex that requires highly trained and qualified practitioners, its scalability therefore limited by the costs of training employing sufficient therapists to meet demand. Behavioural activation (BA) psychological depression may be alternative and, because it simpler, might also delivered less specialised mental health workers.COBRA two-arm, non-inferiority, patient-level randomised controlled trial,...