A5049270568- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
- Sleep and Work-Related Fatigue
- Occupational Health and Performance
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Cancer, Lipids, and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Peroxisome Proliferator-Activated Receptors
- Human-Automation Interaction and Safety
- RNA Research and Splicing
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genomics and Phylogenetic Studies
- Sleep and related disorders
- Parasites and Host Interactions
- Cancer-related molecular mechanisms research
- Cell Image Analysis Techniques
- Machine Learning in Healthcare
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Cardiac Imaging and Diagnostics
- Biofuel production and bioconversion
- Cholesterol and Lipid Metabolism
- MicroRNA in disease regulation
Imperial College London
2023-2024
Baker Heart and Diabetes Institute
2019-2024
Friedrich Miescher Institute
2023
Oxford Archaeology
2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2023
International Federation of Gynaecology and Obstetrics
2023
John Wiley & Sons (United States)
2023
Malaghan Institute of Medical Research
2015-2020
Massey University
2014-2020
University of Lausanne
2017-2020
MicroScope is an integrated platform dedicated to both the methodical updating of microbial genome annotation and comparative analysis. The resource provides data from completed ongoing projects (automatic expert annotations), together with sources post-genomic experiments (i.e. transcriptomics, mutant collections) allowing users perfect improve understanding gene functions. (http://www.genoscope.cns.fr/agc/microscope) combines tools graphical interfaces analyse genomes perform manual...
Defining the immune mechanisms underlying protective immunity to helminth infection remains an important challenge. Here we report that lung CD4+ T cells and Group 2 innate lymphoid (ILC2s) work in concert block Nippostrongylus brasiliensis (Nb) development parenchyma within 48 h mice. Immune-damaged larvae have a striking morphological defect is dependent on expansion of IL-13-producing ILC2 cells, activation M2 macrophages. This T-cell requirement can be bypassed by administration IL-2 or...
The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are unknown.To establish linking anion transport with the functional microanatomy, we evaluated normal and CF piglet trachea as well adult swine in presence of selective inhibitors.We investigated airway microanatomy using microoptical coherence tomography, a new imaging modality that concurrently quantifies multiple parameters epithelium colocalized fashion.Tracheal explants from wild-type demonstrated direct link...
Obesity and related metabolic diseases show clear sex-related differences. The growing burden of these calls for better understanding the age- consequences. High-throughput lipidomic analyses population-based cohorts offer an opportunity to identify disease-risk–associated biomarkers improve our lipid metabolism biology at a population level. Here, we comprehensively examined relationship between classes/subclasses molecular species with age, sex, body mass index (BMI). Furthermore,...
Abstract Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids complex molecules comprising many isomeric isobaric species, necessitating detailed analysis enable interpretation biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for separation characterisation. In this study we examined peripheral samples two cohorts (AIBL, n = 1112 ADNI, 800). We able identify concordant...
<h3>Objective</h3> We aimed to derive and validate a clinical decision rule (CDR) for suspected cardiac chest pain in the emergency department (ED). Incorporating information available at time of first presentation, this CDR would effectively risk-stratify patients immediately identify: (A) whom hospitalisation may be safely avoided; (B) high-risk patients, facilitating judicious use resources. <h3>Methods</h3> In two sequential prospective observational cohort studies heterogeneous centres,...
The dendritic cell signals required for the in vivo priming of IL-4–producing T cells are unknown. We used RNA sequencing to characterize DCs from skin LN mice exposed two different Th2 stimuli: helminth parasite Nippostrongylus brasiliensis (Nb) and contact sensitizer dibutyl phthalate (DBP)-FITC. Both Nb DBP-FITC induced extensive transcriptional changes that involved multiple DC subsets. Surprisingly, these were highly distinct models, with only a small number genes being similarly...
Intergenic long noncoding RNAs (lincRNAs) are the largest class of transcripts in human genome. Although many have recently been linked to complex traits, underlying mechanisms for most these remain undetermined. We investigated regulatory roles a high-confidence and reproducible set 69 trait-relevant lincRNAs (TR-lincRNAs) lymphoblastoid cells whose biological relevance is supported by their evolutionary conservation during recent history genetic interactions with other trait-associated...
C. elegans develops through four larval stages that are rhythmically terminated by molts, is, the synthesis and shedding of a cuticular exoskeleton. Each cycle involves rhythmic accumulation thousands transcripts, which we show here relies on transcription. To uncover responsible gene regulatory networks (GRNs), screened for transcription factors promote progression identified GRH-1, BLMP-1, NHR-23, NHR-25, MYRF-1, BED-3. We further characterize Grainyhead/LSF factor, whose orthologues in...
Summary The K arolinska S leepiness cale and amn– P erelli fatigue ratings, psychomotor vigilance task performance are proposed as measures for monitoring commercial pilot fatigue. In laboratory studies, they sensitive to sleep/wake history circadian phase. present analyses examined whether reliably reflect phase during transmeridian flight operations. Data were combined from four studies (237 pilots, 730 out‐and‐back flights between 13 city pairs, 1–3‐day layovers). Sleep was monitored...
Plasmalogens are membrane glycerophospholipids with diverse biological functions. Reduced plasmalogen levels have been observed in metabolic diseases; hence, increasing their might be beneficial ameliorating these conditions. Shark liver oil (SLO) is a rich source of alkylglycerols that can metabolized into plasmalogens. This study was designed to evaluate the impact SLO supplementation on endogenous individuals features disease. In this randomized, double-blind, placebo-controlled...
Of all biochemically characterized metabolic reactions formalized by the IUBMB, over one out of four have yet to be associated with a nucleic or protein sequence, i.e. are sequence-orphan enzymatic activities. Few bioinformatics annotation tools able propose candidate genes for such activities exploiting context-dependent rather than sequence-dependent data, and none readily accessible result integration across multiple genomes. Here, we present CanOE (Candidate Orphan Enzymes), four-step...
Implementation of Fatigue Risk Management Systems (FRMS) is gaining momentum; however, agreed safety performance indicators (SPIs) are lacking. This paper proposes an initial set SPIs based on measures crewmember sleep, performance, and subjective fatigue sleepiness, together with methods for interpreting them.Data were included from 133 landing crewmembers 2 long-range 3 ultra-long-range trips (4-person crews, airlines, 220 flights). Studies had airline, labor, regulatory support, underwent...
Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and thought to have protective effects against metabolic disease. Dietary supplementation alkylglycerols (AKGs) has been shown increase endogenous plasmalogen levels, however effective modulation different molecular species not yet demonstrated. In this study, the an orally-administered AKG mix (a mixture chimyl, batyl selachyl alcohol at 1:1:1 ratio) on plasma tissue lipids,...
Natural language processing (NLP) algorithms are increasingly being applied to obtain unsupervised representations of electronic health record (EHR) data, but their comparative performance at predicting clinical endpoints remains unclear. Our objective was compare the sequences disease codes generated by bag-of-words versus sequence-based NLP clinically relevant outcomes.
The R package SIMoNe (Statistical Inference for MOdular NEtworks) enables inference of gene-regulatory networks based on partial correlation coefficients from microarray experiments. Modelling gene expression data with a Gaussian graphical model (hereafter GGM), the algorithm estimates non-zero entries concentration matrix, in sparse and possibly high-dimensional setting. Its originality lies fact that it searches latent modular structure to drive procedure through adaptive penalization...
Tropical aquatic species of the legume genus Aeschynomene are stem- and root-nodulated by bradyrhizobia strains that exhibit atypical features such as photosynthetic capacities or use a nod gene-dependent (ND) gene-independent (NI) pathway to enter into symbiosis with legumes. In this study we used comparative genomics approach on nine symbionts representative their phylogenetic diversity. We produced draft genomes bradyrhizobial representing different phenotypes: five NI (STM3809, ORS375,...
Flight timing is expected to influence pilot fatigue because it determines the part of circadian body clock cycle that traversed during a flight. However effects flight are not well-characterized field studies typically focus on specific flights with limited range departure times and have small sample sizes. The present project combined data from four studies, including 13 long-range ultra-long out-and-back trips across arrival (237 pilots in 4-person crews, 730 segments, 1-3 d layovers).All...
As part of on-going efforts to control hookworm infection, the "human vaccine initiative" has recognised blood feeding as a feasible therapeutic target for inducing immunity against infection. To this end, molecular approaches have been used identify candidate targets, such Necator americanus (Na) haemoglobinase aspartic protease-1 (APR-1), with immunogenicity profiled in canine and hamster models. We sought accelerate immune analysis these identified targets by developing an appropriate...
The aims of this study were to monitor cabin crew fatigue, sleep, and performance on an ultra-long range (ULR) trip evaluate the appropriateness applying data collection methods developed for flight operations under a fatigue risk management system (FRMS).Prior to, throughout, following ULR (outbound ULR; mean layover duration=52.6 h; inbound long range), 55 (29 women; age 36.5 yr; 25 men; 36.6 one missing data) completed sleep/duty diary wore actigraph. Across each flight, crewmembers rated...