A5074864332- Glutathione Transferases and Polymorphisms
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Health and Medical Research Impacts
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and biosynthesis
- Doctoral Education Challenges and Solutions
- Sphingolipid Metabolism and Signaling
- Selenium in Biological Systems
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Trace Elements in Health
- Pancreatic function and diabetes
- Innovations in Medical Education
- Metabolism and Genetic Disorders
University of Massachusetts Chan Medical School
2020-2023
Inducers of ferroptosis such as the glutathione depleting agent Erastin and GPX4 inhibitor Rsl-3 are being actively explored potential therapeutics in various cancers, but factors that determine their sensitivity poorly understood. Here, we show expression levels both subunits cystine/glutamate antiporter xCT breast cancer, upregulation xCT/selenocysteine biosynthesis/GPX4 production axis paradoxically renders cancer cells more sensitive to certain types ferroptotic stimuli. We find is...
Sphingolipids play important signaling and structural roles in cells. Here, we find that during de novo sphingolipid biosynthesis, a toxic metabolite is formed with critical implications for cancer cell survival. The enzyme catalyzing the first step this pathway, serine palmitoyltransferase complex (SPT), upregulated breast other cancers. SPT dispensable proliferation, as sphingolipids can be salvaged from environment. However, activity introduces liability its product,...