A5088202593- Cardiovascular Health and Disease Prevention
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Physical Activity and Health
- Thermoregulation and physiological responses
- Cardiovascular Effects of Exercise
- Mitochondrial Function and Pathology
- Chemotherapy-induced cardiotoxicity and mitigation
- Sphingolipid Metabolism and Signaling
- Nitric Oxide and Endothelin Effects
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Cerebrovascular and Carotid Artery Diseases
- Sleep and Wakefulness Research
- Antioxidant Activity and Oxidative Stress
- Parkinson's Disease Mechanisms and Treatments
- Ion Transport and Channel Regulation
- ATP Synthase and ATPases Research
- Cancer survivorship and care
- Body Composition Measurement Techniques
University of Florida
2016-2025
Florida College
2016-2022
Health & Life (Taiwan)
2020
Beth Israel Deaconess Medical Center
2018
Christ University
2015-2018
Tufts Medical Center
2018
Harvard University
2018
University of Colorado Boulder
2002-2009
University of Colorado Health
2003-2007
University of Thessaly
2007
Background— Short-term and tonic regulation of arterial blood pressure (BP) differ in premenopausal women men similar age. The autonomic nervous system (ANS) plays a critical role BP regulation. Methods Results— To test the hypothesis that have lower ANS support (reduction intra-arterial during acute ganglionic blockade [GB] with intravenous trimethaphan) less effective baroreflex buffering (BRB) (potentiation systolic [SBP] response to bolus phenylephrine versus before GB) than men, 51...
Obesity may alter vascular endothelial cell protein expression (VECPE) of molecules that influence susceptibility to atherosclerosis.Quantitative immunofluorescence was performed on cells collected from 108 men and women free clinical disease who varied widely in adiposity (body mass index 18.4 36.7 kg/m2; total body fat 5.8 55.0 kg; waist circumference: 63.0 122.9 cm). All 3 expressions were positively associated with VECPE the oxidant enzyme subunit NAD(P)H oxidase-p47(phox) (part...
Key points Although doxorubicin is a highly effective anti‐tumour agent, the administration of this drug associated with significant side effects, including contractile dysfunction and myopathy both cardiac skeletal muscles. The mechanism(s) responsible for doxorubicin‐induced in muscles remains unclear. In present study, we report that increased mitochondrial oxidant production calpain activation are major contributors to development myopathy. Moreover, treatment mitochondrial‐targeted...
Hypertension is nearly universal yet poorly controlled in the elderly despite proven benefits of intensive treatment. Mice lacking mineralocorticoid receptors smooth muscle cells (SMC-MR-KO) are protected from rising blood pressure (BP) with aging, normal renal function. Vasoconstriction attenuated aged SMC-MR-KO mice, thus they were used to explore vascular mechanisms that may contribute hypertension aging. MicroRNA (miR) profiling identified miR-155 as most down-regulated miR aging...
Objective: The current randomized controlled trial tested the hypothesis that both aerobic training and dynamic resistance will improve inflammation, endothelial function 24-h ambulatory blood pressure (ABP) in middle-aged adults with hypertension, but would be more effective. Methods: Forty-two hypertensive patients on at least one antihypertensive medication (19 men/23 women; 30–59 years of age) were randomly assigned to 12 weeks supervised ( n = 15), 15) or a nonexercise control 12)...
Background— Baroreflex buffering is an important mechanism in arterial blood pressure control. The effect of healthy (physiological) aging on tonic baroreflex humans unknown. Methods and Results— was determined 27 young (aged 25±1 years) 16 older 65±1 normotensive men by measuring the potentiation systolic (SBP) responses to a phenylephrine bolus (BRB ) incremental infusion slope during compared with before ganglionic blockade trimethaphan. SBP either were not different or greater blockade,...
A decrease in maximal exercise heart rate (HR(max)) is a key contributor to reductions aerobic capacity with aging. However, the mechanisms involved are incompletely understood. We sought gain insight into respective roles of intrinsic (HR(int)) and chronotropic beta-adrenergic responsiveness HR(max) aging healthy adults. (Balke treadmill protocol exhaustion), HR(int) (HR during acute ganglionic blockade intravenous trimethaphan), (increase HR incremental infusion isoproterenol blockade)...
Background— The prevalence of cardiovascular disease (CVD) is partly attributable to an inactive and/or overweight population. However, the independent association body fatness and aerobic fitness with CVD risk factors uncertain. We sought determine whether or better predicted traditional in men broad fatness, fitness, age ranges using 3 expressions adiposity. Methods Results— In 135 carefully screened healthy men, we measured 18 established factors, mass index, total percent fat, waist...
Key points In aged rats, daily muscle stretching increases blood flow to skeletal during exercise. Daily enhanced endothelium‐dependent vasodilatation of resistance arterioles rats. Angiogenic markers and capillarity increased in response muscles Muscle performed with a splint could provide feasible means improving function elderly patients who cannot perform regular aerobic Abstract Mechanical stretch stimuli alter the morphology cultured endothelial cells; however, little is known about...
Stiffening of the vasculature with aging is a strong predictor adverse cardiovascular events, independent all other risk factors including blood pressure, yet no therapies target this process. MRs (mineralocorticoid receptors) in smooth muscle cells (SMCs) have been implicated regulation vascular fibrosis but not explored aging. Comparing SMC-MR-deleted male mice to MR-intact littermates at 3, 12, and 18 months age, we demonstrated that aging-associated stiffening are mitigated by MR...
Chronic kidney disease (CKD) causes progressive skeletal myopathy involving atrophy, weakness, and fatigue. Mitochondria have been thought to contribute myopathy; however, the molecular mechanisms underlying muscle metabolism changes in CKD are unknown. We employed a comprehensive mitochondrial phenotyping platform elucidate of impairment mice with adenine-induced CKD. displayed significant reductions oxidative phosphorylation (OXPHOS), which was strongly correlated glomerular filtration...
Large elastic arteries stiffen with age, which predisposes older adults to increased risk for cardiovascular disease. Aerobic exercise training is known reduce the disease, but optimal prescription attenuating large arterial stiffening in not known.The purpose of this randomized controlled trial was compare effect all-extremity high-intensity interval (HIIT) and moderate-intensity continuous (MICT) on aortic pulse wave velocity (PWV) carotid artery compliance adults.Forty-nine sedentary (age...
Background Endurance exercise improves aerobic capacity (VO 2peak ) and motor symptoms in people with early Parkinson's disease (PD). Some PD exhibit signs of chronotropic incompetence (CI), which may impact exercise-induced benefits. Objective We investigated whether CI influences the change signs, VO , peak heart rate (HR) following 6 months endurance exercise. Methods performed secondary analyses Study Disease Exercise (SPARX), randomized into a high-intensity [80–85% HR],...
Obesity increases linearly with age and is associated impaired vascular endothelial function increased risk of cardiovascular disease. MRs (mineralocorticoid receptors) contribute to in disease; however, their role uncomplicated human obesity unknown. Because plasma aldosterone levels are elevated adipocytes may be a source aldosterone, we hypothesized that modulate older adults an adiposity-dependent manner. To test this hypothesis, administered MR blockade (eplerenone; 100 mg/day) for 1...
Abstract Background To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits endurance exercise among persons with PD. The key question is whether there a definitive additional benefit exercising at high intensity, in terms slowing progression, beyond well-documented training treadmill for fitness, gait, functional mobility. This study will determine efficacy high-intensity as...
Diaphragm muscle weakness in chronic heart failure (CHF) is caused by elevated oxidants and exacerbates breathing abnormalities, exercise intolerance, dyspnea. However, the specific source of that cause diaphragm unknown. We examined whether mitochondrial reactive oxygen species (ROS) CHF testing hypothesis animals treated with a mitochondria-targeted antioxidant have normal function. Rats underwent or sham surgery. Eight weeks after surgeries, we administered mitochondrial-targeted...
The sympathetic nervous system contributes to resting metabolic rate (RMR) via beta-adrenergic receptor (beta-AR) stimulation of energy metabolism. RMR and beta-AR support are greater in habitually exercising compared with sedentary older adults possibly due flux (magnitude intake expenditure during balance). In 10 regularly performing aerobic endurance exercise (mean +/- se, 66 1 yr) baseline, a reduction (via abstention proportional dietary intake) decreased (P < 0.05) (7746 440 vs. 9630...
Studying molecular mechanisms of vascular endothelial function in humans is difficult part because limited access to arteries. Access peripheral veins more practical. We determined if differences protein expression cells (EC) collected from a artery are reflected measurements made on EC obtained veins. were the brachial and an antecubital vein 106 healthy adults (60 men 46 women, age 18–77 years). Quantitative immunofluorescence was used measure nitric oxide synthase (eNOS), Ser-1177...